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CRISPR-CasΦ from huge phages is a hypercompact genome editor.

Pausch P, Al-Shayeb B, Bisom-Rapp E, Tsuchida CA, Li Z, Cress BF, Knott GJ, Jacobsen SE, Banfield JF, Doudna JA. Pausch P, et al. Among authors: jacobsen se. Science. 2020 Jul 17;369(6501):333-337. doi: 10.1126/science.abb1400. Science. 2020. PMID: 32675376 Free PMC article.

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DNA methylation pathways and their crosstalk with histone methylation.

Du J, Johnson LM, Jacobsen SE, Patel DJ. Du J, et al. Among authors: jacobsen se. Nat Rev Mol Cell Biol. 2015 Sep;16(9):519-32. doi: 10.1038/nrm4043. Nat Rev Mol Cell Biol. 2015. PMID: 26296162 Free PMC article. Review.

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MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO.

Ichino L, Boone BA, Strauskulage L, Harris CJ, Kaur G, Gladstone MA, Tan M, Feng S, Jami-Alahmadi Y, Duttke SH, Wohlschlegel JA, Cheng X, Redding S, Jacobsen SE. Ichino L, et al. Among authors: jacobsen se. Science. 2021 Jun 3:eabg6130. doi: 10.1126/science.abg6130. Online ahead of print. Science. 2021. PMID: 34083448

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A DNA methylation reader complex that enhances gene transcription.

Harris CJ, Scheibe M, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F, Jacobsen SE. Harris CJ, et al. Among authors: jacobsen se. Science. 2018 Dec 7;362(6419):1182-1186. doi: 10.1126/science.aar7854. Science. 2018. PMID: 30523112 Free PMC article.

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Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation.

Wang Q, Xue Y, Zhang L, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris CJ, Wu Z, Zhai J, Yang M, Li S, Jacobsen SE, Du J. Wang Q, et al. Among authors: jacobsen se. Science. 2021 Nov 26;374(6571):1152-1157. doi: 10.1126/science.abl4546. Epub 2021 Oct 14. Science. 2021. PMID: 34648373 Free PMC article.

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Establishing, maintaining and modifying DNA methylation patterns in plants and animals.

Law JA, Jacobsen SE. Law JA, et al. Among authors: jacobsen se. Nat Rev Genet. 2010 Mar;11(3):204-20. doi: 10.1038/nrg2719. Nat Rev Genet. 2010. PMID: 20142834 Free PMC article. Review.

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Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.

Yan Y, Liu Q, Zang X, Yuan S, Bat-Erdene U, Nguyen C, Gan J, Zhou J, Jacobsen SE, Tang Y. Yan Y, et al. Among authors: jacobsen se. Nature. 2018 Jul;559(7714):415-418. doi: 10.1038/s41586-018-0319-4. Epub 2018 Jul 11. Nature. 2018. PMID: 29995859 Free PMC article.

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Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome.

Stroud H, Greenberg MV, Feng S, Bernatavichute YV, Jacobsen SE. Stroud H, et al. Among authors: jacobsen se. Cell. 2013 Jan 17;152(1-2):352-64. doi: 10.1016/j.cell.2012.10.054. Epub 2013 Jan 11. Cell. 2013. PMID: 23313553 Free PMC article.

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Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning.

Cokus SJ, Feng S, Zhang X, Chen Z, Merriman B, Haudenschild CD, Pradhan S, Nelson SF, Pellegrini M, Jacobsen SE. Cokus SJ, et al. Among authors: jacobsen se. Nature. 2008 Mar 13;452(7184):215-9. doi: 10.1038/nature06745. Epub 2008 Feb 17. Nature. 2008. PMID: 18278030 Free PMC article.

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Plant genome engineering from lab to field-a Keystone Symposia report.

Cable J, Ronald PC, Voytas D, Zhang F, Levy AA, Takatsuka A, Arimura SI, Jacobsen SE, Toki S, Toda E, Gao C, Zhu JK, Boch J, Van Eck J, Mahfouz M, Andersson M, Fridman E, Weiss T, Wang K, Qi Y, Jores T, Adams T, Bagchi R. Cable J, et al. Among authors: jacobsen se. Ann N Y Acad Sci. 2021 Dec;1506(1):35-54. doi: 10.1111/nyas.14675. Epub 2021 Aug 25. Ann N Y Acad Sci. 2021. PMID: 34435370 Review.

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