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Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis.

Barbosa DM, Fahlbusch P, Herzfeld de Wiza D, Jacob S, Kettel U, Al-Hasani H, Krüger M, Ouwens DM, Hartwig S, Lehr S, Kotzka J, Knebel B. Barbosa DM, et al. Among authors: jacob s. Sci Rep. 2020 Mar 17;10(1):4888. doi: 10.1038/s41598-020-61886-3. Sci Rep. 2020. PMID: 32184434 Free PMC article.

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Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.

Fahlbusch P, Knebel B, Hörbelt T, Barbosa DM, Nikolic A, Jacob S, Al-Hasani H, Van de Velde F, Van Nieuwenhove Y, Müller-Wieland D, Lapauw B, Ouwens DM, Kotzka J. Fahlbusch P, et al. Among authors: jacob s. Int J Mol Sci. 2020 Jun 10;21(11):4144. doi: 10.3390/ijms21114144. Int J Mol Sci. 2020. PMID: 32532003 Free PMC article.

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Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome.

Knebel B, Fahlbusch P, Dille M, Wahlers N, Hartwig S, Jacob S, Kettel U, Schiller M, Herebian D, Koellmer C, Lehr S, Müller-Wieland D, Kotzka J. Knebel B, et al. Among authors: jacob s. Front Cell Dev Biol. 2019 Oct 25;7:248. doi: 10.3389/fcell.2019.00248. eCollection 2019. Front Cell Dev Biol. 2019. PMID: 31709254 Free PMC article.

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[False hypoxia in a newborn due to a haemoglobin F polymorphism].

Jacob S, Teles MJ, Rocha G, Ferreira F, Guimarães H. Jacob S, et al. An Pediatr (Engl Ed). 2018 Apr;88(4):234-235. doi: 10.1016/j.anpedi.2017.12.007. An Pediatr (Engl Ed). 2018. PMID: 29422301 Spanish. No abstract available.

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[Cow's milk protein intolerance imitating septic shock in a young infant].

Jacob S, Bonito Vitor A. Jacob S, et al. An Pediatr (Engl Ed). 2019 Jan;90(1):52-53. doi: 10.1016/j.anpedi.2018.01.020. Epub 2018 Apr 9. An Pediatr (Engl Ed). 2019. PMID: 29650430 Free article. Spanish. No abstract available.

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Alteration of Liver Peroxisomal and Mitochondrial Functionality in the NZO Mouse Model of Metabolic Syndrome.

Knebel B, Göddeke S, Hartwig S, Hörbelt T, Fahlbusch P, Al-Hasani H, Jacob S, Koellmer C, Nitzgen U, Schiller M, Lehr S, Kotzka J. Knebel B, et al. Among authors: jacob s. Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700028. Epub 2017 Dec 11. Proteomics Clin Appl. 2018. PMID: 29068532

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CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.

Göddeke S, Knebel B, Fahlbusch P, Hörbelt T, Poschmann G, van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Nieuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J. Göddeke S, et al. Among authors: jacob s. Int J Obes (Lond). 2018 Jun;42(5):1039-1050. doi: 10.1038/s41366-018-0022-4. Epub 2018 Feb 21. Int J Obes (Lond). 2018. PMID: 29467502

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Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.

Knebel B, Goeddeke S, Poschmann G, Markgraf DF, Jacob S, Nitzgen U, Passlack W, Preuss C, Dicken HD, Stühler K, Hartwig S, Lehr S, Kotzka J. Knebel B, et al. Among authors: jacob s. Int J Mol Sci. 2017 Sep 8;18(9):1928. doi: 10.3390/ijms18091928. Int J Mol Sci. 2017. PMID: 28885548 Free PMC article.

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So close and yet so far: mitochondria and peroxisomes are one but with specific talents.

Hartwig S, Knebel B, Goeddeke S, Koellmer C, Jacob S, Nitzgen U, Passlack W, Schiller M, Dicken HD, Haas J, Muller-Wieland D, Lehr S, Kotzka J. Hartwig S, et al. Among authors: jacob s. Arch Physiol Biochem. 2013 Jul;119(3):126-35. doi: 10.3109/13813455.2013.796994. Epub 2013 May 24. Arch Physiol Biochem. 2013. PMID: 23705958

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Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition.

Knebel B, Fahlbusch P, Poschmann G, Dille M, Wahlers N, Stühler K, Hartwig S, Lehr S, Schiller M, Jacob S, Kettel U, Müller-Wieland D, Kotzka J. Knebel B, et al. Among authors: jacob s. Int J Mol Sci. 2019 May 24;20(10):2559. doi: 10.3390/ijms20102559. Int J Mol Sci. 2019. PMID: 31137678 Free PMC article.

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