Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Santos-Zas I, Lemarié J, Zlatanova I, Cachanado M, Seghezzi JC, Benamer H, Goube P, Vandestienne M, Cohen R, Ezzo M, Duval V, Zhang Y, Su JB, Bizé A, Sambin L, Bonnin P, Branchereau M, Heymes C, Tanchot C, Vilar J, Delacroix C, Hulot JS, Cochain C, Bruneval P, Danchin N, Tedgui A, Mallat Z, Simon T, Ghaleh B, Silvestre JS, Ait-Oufella H.
Santos-Zas I, et al.
Nat Commun. 2021 Mar 5;12(1):1483. doi: 10.1038/s41467-021-21737-9.
Nat Commun. 2021.
PMID: 33674611
Free PMC article.
Depletion of CD8(+) T lymphocytes decreases apoptosis within the ischemic myocardium, hampers inflammatory response, limits myocardial injury and improves heart function. ...Finally, we reveal that elevated circulating levels of GRANZYME B in patients with acute myocardial …
Depletion of CD8(+) T lymphocytes decreases apoptosis within the ischemic myocardium, hampers inflammatory response, limits myocardia …