T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.
Cimen Bozkus C, Brown M, Velazquez L, Thomas M, Wilson EA, O'Donnell T, Kaminska A, Ruchnewitz D, Geertz D, Bykov Y, Kodysh J, Oguntuyo KY, Roudko V, Hoyos D, Srivastava KD, Kleiner G, Alshammary H, Karekar N, McClain C, Gopal R, Nie K, Del Valle D, Delbeau-Zagelbaum D, Rodriguez D, Setal J; Mount Sinai COVID-19 Biobank Team; Carroll E, Wiesendanger M, Gulko PS, Charney A, Merad M, Kim-Schulze S, Lee B, Wajnberg A, Simon V, Greenbaum BD, Chowell D, Vabret N, Luksza M, Bhardwaj N.
Cimen Bozkus C, et al.
iScience. 2025 Jul 2;28(8):113044. doi: 10.1016/j.isci.2025.113044. eCollection 2025 Aug 15.
iScience. 2025.
PMID: 40746995
Free PMC article.
Understanding the breadth and functional profile of T cell responses is crucial for assessing their role in immune surveillance of emerging SARS-CoV-2 variants. Sampling healthy individuals, we profiled the kinetics and polyfunctionality of T cell immunity elicited …
Understanding the breadth and functional profile of T cell responses is crucial for assessing their role in immune surveillance of em …