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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1954 1
1968 3
1975 11
1976 5
1977 12
1978 18
1979 12
1980 26
1981 28
1982 27
1983 31
1984 36
1985 36
1986 38
1987 148
1988 321
1989 305
1990 310
1991 359
1992 355
1993 380
1994 431
1995 373
1996 409
1997 402
1998 389
1999 388
2000 434
2001 465
2002 438
2003 456
2004 490
2005 482
2006 400
2007 409
2008 475
2009 548
2010 604
2011 672
2012 739
2013 905
2014 1329
2015 1586
2016 1313
2017 1124
2018 1769
2019 1950
2020 2108
2021 2161
2022 2056
2023 1885
2024 869

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27,475 results

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Page 1
Clinical implications of T cell exhaustion for cancer immunotherapy.
Chow A, Perica K, Klebanoff CA, Wolchok JD. Chow A, et al. Nat Rev Clin Oncol. 2022 Dec;19(12):775-790. doi: 10.1038/s41571-022-00689-z. Epub 2022 Oct 10. Nat Rev Clin Oncol. 2022. PMID: 36216928 Free PMC article. Review.
However, cancer is associated with T cell exhaustion, a hypofunctional state characterized by progressive loss of T cell effector functions and self-renewal capacity. The 'un-exhausting' of T cells in the tumour microenvironment is commonly regarded as a key …
However, cancer is associated with T cell exhaustion, a hypofunctional state characterized by progressive loss of T cell effec …
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.
Rojas LA, Sethna Z, Soares KC, Olcese C, Pang N, Patterson E, Lihm J, Ceglia N, Guasp P, Chu A, Yu R, Chandra AK, Waters T, Ruan J, Amisaki M, Zebboudj A, Odgerel Z, Payne G, Derhovanessian E, Müller F, Rhee I, Yadav M, Dobrin A, Sadelain M, Łuksza M, Cohen N, Tang L, Basturk O, Gönen M, Katz S, Do RK, Epstein AS, Momtaz P, Park W, Sugarman R, Varghese AM, Won E, Desai A, Wei AC, D'Angelica MI, Kingham TP, Mellman I, Merghoub T, Wolchok JD, Sahin U, Türeci Ö, Greenbaum BD, Jarnagin WR, Drebin J, O'Reilly EM, Balachandran VP. Rojas LA, et al. Nature. 2023 Jun;618(7963):144-150. doi: 10.1038/s41586-023-06063-y. Epub 2023 May 10. Nature. 2023. PMID: 37165196 Free PMC article. Clinical Trial.
Using a new mathematical strategy to track T cell clones (CloneTrack) and functional assays, we found that vaccine-expanded T cells comprised up to 10% of all blood T cells, re-expanded with a vaccine booster and included long-lived polyfunctional neoantigen- …
Using a new mathematical strategy to track T cell clones (CloneTrack) and functional assays, we found that vaccine-expanded T …
Senolytic CAR T cells reverse senescence-associated pathologies.
Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW. Amor C, et al. Nature. 2020 Jul;583(7814):127-132. doi: 10.1038/s41586-020-2403-9. Epub 2020 Jun 17. Nature. 2020. PMID: 32555459 Free PMC article.
Here we test the therapeutic concept that chimeric antigen receptor (CAR) T cells that target senescent cells can be effective senolytic agents. We identify the urokinase-type plasminogen activator receptor (uPAR)(11) as a cell-surface protein that is broadly induced durin …
Here we test the therapeutic concept that chimeric antigen receptor (CAR) T cells that target senescent cells can be effective senoly …
Metastasis.
Gerstberger S, Jiang Q, Ganesh K. Gerstberger S, et al. Cell. 2023 Apr 13;186(8):1564-1579. doi: 10.1016/j.cell.2023.03.003. Cell. 2023. PMID: 37059065 Free PMC article. Review.
Principles of regulatory T cell function.
Dikiy S, Rudensky AY. Dikiy S, et al. Immunity. 2023 Feb 14;56(2):240-255. doi: 10.1016/j.immuni.2023.01.004. Immunity. 2023. PMID: 36792571 Free article. Review.
Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal autoimmune and inflammatory pathologies. ...
Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal au …
Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade.
Pai JA, Hellmann MD, Sauter JL, Mattar M, Rizvi H, Woo HJ, Shah N, Nguyen EM, Uddin FZ, Quintanal-Villalonga A, Chan JM, Manoj P, Allaj V, Baine MK, Bhanot UK, Jain M, Linkov I, Meng F, Brown D, Chaft JE, Plodkowski AJ, Gigoux M, Won HH, Sen T, Wells DK, Donoghue MTA, de Stanchina E, Wolchok JD, Loomis B, Merghoub T, Rudin CM, Chow A, Satpathy AT. Pai JA, et al. Cancer Cell. 2023 Apr 10;41(4):776-790.e7. doi: 10.1016/j.ccell.2023.03.009. Epub 2023 Mar 30. Cancer Cell. 2023. PMID: 37001526 Free PMC article.
Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. ...Regions with viable cancer cells are enriched for exhausted CD8(+) T cells, regulatory CD4(+) T cells (Tre …
Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dyn …
Chromatin states define tumour-specific T cell dysfunction and reprogramming.
Philip M, Fairchild L, Sun L, Horste EL, Camara S, Shakiba M, Scott AC, Viale A, Lauer P, Merghoub T, Hellmann MD, Wolchok JD, Leslie CS, Schietinger A. Philip M, et al. Nature. 2017 May 25;545(7655):452-456. doi: 10.1038/nature22367. Epub 2017 May 17. Nature. 2017. PMID: 28514453 Free PMC article.
Tumour-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability (for example, to immune checkpoint blockade) is not well understood. ...We identified surf …
Tumour-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to progress. The epigenetic regulation of T c …
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape.
Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, Li Z, Cunanan KM, Huse M, Hendrickson RC, Wang X, Rivière I, Sadelain M. Hamieh M, et al. Nature. 2019 Apr;568(7750):112-116. doi: 10.1038/s41586-019-1054-1. Epub 2019 Mar 27. Nature. 2019. PMID: 30918399 Free PMC article.
Chimeric antigen receptors (CARs) are synthetic antigen receptors that reprogram T cell specificity, function and persistence(1). Patient-derived CAR T cells have demonstrated remarkable efficacy against a range of B-cell malignancies(1-3), and the results of early …
Chimeric antigen receptors (CARs) are synthetic antigen receptors that reprogram T cell specificity, function and persistence(1). Pat …
HLA-independent T cell receptors for targeting tumors with low antigen density.
Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, Zucchetti AE, Li Z, Sjöstrand M, Lindenbergh PL, Saetersmoen M, Dobrin A, Maurin M, Iyer A, Garcia Angus A, Miele MM, Zhao Z, Giavridis T, van der Stegen SJC, Tamzalit F, Rivière I, Huse M, Hendrickson RC, Hivroz C, Sadelain M. Mansilla-Soto J, et al. Nat Med. 2022 Feb;28(2):345-352. doi: 10.1038/s41591-021-01621-1. Epub 2022 Jan 13. Nat Med. 2022. PMID: 35027758 Free PMC article.
Here we edit the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor-CD3 complex reconfigured to utilize the same immunoglobulin heavy and light chains as a matched CAR. We demonstrate that these HLA-independent …
Here we edit the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor-CD3 …
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, Nainys J, Wu K, Kiseliovas V, Setty M, Choi K, Fromme RM, Dao P, McKenney PT, Wasti RC, Kadaveru K, Mazutis L, Rudensky AY, Pe'er D. Azizi E, et al. Cell. 2018 Aug 23;174(5):1293-1308.e36. doi: 10.1016/j.cell.2018.05.060. Epub 2018 Jun 28. Cell. 2018. PMID: 29961579 Free PMC article.
Despite significant similarity between normal and tumor tissue-resident immune cells, we observed continuous phenotypic expansions specific to the tumor microenvironment. Analysis of paired single-cell RNA and T cell receptor (TCR) sequencing data from 27,000 additional …
Despite significant similarity between normal and tumor tissue-resident immune cells, we observed continuous phenotypic expansions specific …
27,475 results
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