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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1969 1
1972 1
1975 4
1976 4
1977 5
1978 6
1979 3
1980 2
1981 4
1982 5
1983 3
1984 4
1985 7
1986 9
1987 17
1988 11
1989 10
1990 14
1991 7
1992 6
1993 11
1994 12
1995 14
1996 8
1997 20
1998 16
1999 16
2000 30
2001 28
2002 35
2003 18
2004 23
2005 39
2006 37
2007 35
2008 43
2009 35
2010 40
2011 62
2012 56
2013 68
2014 63
2015 106
2016 119
2017 110
2018 132
2019 114
2020 129
2021 136
2022 110
2023 21
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1,664 results
Results by year
Filters applied: . Clear all Your search was processed without automatic term mapping because it retrieved zero results.
Page 1
T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.
Utzschneider DT, Charmoy M, Chennupati V, Pousse L, Ferreira DP, Calderon-Copete S, Danilo M, Alfei F, Hofmann M, Wieland D, Pradervand S, Thimme R, Zehn D, Held W. Utzschneider DT, et al. Immunity. 2016 Aug 16;45(2):415-27. doi: 10.1016/j.immuni.2016.07.021. Immunity. 2016. PMID: 27533016 Free article.
Chronic infections promote the terminal differentiation (or "exhaustion") of T cells and are thought to preclude the formation of memory T cells. In contrast, we discovered a small subpopulation of virus-specific CD8(+) T cells that sustained the T cel …
Chronic infections promote the terminal differentiation (or "exhaustion") of T cells and are thought to preclude the formation of mem …
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. Chan EM, et al. Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10. Nature. 2019. PMID: 30971823 Free PMC article.
Professor Dr. Werner Bohndorf gestorben.
Flentje M, Richter J. Flentje M, et al. Strahlenther Onkol. 2021 Jul;197(7):664-665. doi: 10.1007/s00066-021-01792-3. Epub 2021 Jun 8. Strahlenther Onkol. 2021. PMID: 34100963 Free PMC article. German. No abstract available.
Werner syndrome in a Lebanese family.
Jaafar B, Nasrallah M, Sievers B, Oshima J, Lessel D. Jaafar B, et al. Am J Med Genet A. 2022 May;188(5):1630-1634. doi: 10.1002/ajmg.a.62654. Epub 2022 Jan 17. Am J Med Genet A. 2022. PMID: 35037378
Werner syndrome (WS) is an extremely rare, autosomal recessive segmental progeroid disorder caused by biallelic pathogenic variants in the WRN, which encodes a multifunctional nuclear protein that belongs to the RecQ family of DNA helicases. ...Here, we report a consanguin
Werner syndrome (WS) is an extremely rare, autosomal recessive segmental progeroid disorder caused by biallelic pathogenic variants i
T cells as antigen-presenting cells.
Pichler WJ, Wyss-Coray T. Pichler WJ, et al. Immunol Today. 1994 Jul;15(7):312-5. doi: 10.1016/0167-5699(94)90078-7. Immunol Today. 1994. PMID: 7522009 Review.
In this guise, T cells provide downregulatory signals for the immune response by inducing anergy in T cells that have already been activated and cytotoxicity in resting T cells. Here, Werner Pichler and Tony Wyss-Coray suggest that this may represent a …
In this guise, T cells provide downregulatory signals for the immune response by inducing anergy in T cells that have already …
Reduction of Werner Syndrome Protein Enhances G:C → A:T Transition by O6-Methylguanine in Human Cells.
Suzuki T, Kuramoto Y, Kamiya H. Suzuki T, et al. Chem Res Toxicol. 2018 May 21;31(5):319-324. doi: 10.1021/acs.chemrestox.8b00009. Epub 2018 Apr 12. Chem Res Toxicol. 2018. PMID: 29616805
O(6)-Methylguanine ( O(6)-MeG) is a damaged base produced by methylating reagents. The Werner syndrome protein (WRN) is a cancer-related human DNA helicase. ...The lowered amount of WRN increased the frequency of mutations induced by O(6)-MeG, mainly G:C A:T substit …
O(6)-Methylguanine ( O(6)-MeG) is a damaged base produced by methylating reagents. The Werner syndrome protein (WRN) is a cancer-rela …
T cells in drug allergy.
Pichler WJ. Pichler WJ. Curr Allergy Asthma Rep. 2002 Jan;2(1):9-15. doi: 10.1007/s11882-002-0032-z. Curr Allergy Asthma Rep. 2002. PMID: 11895620 Review.
In recent years, increasing evidence has indicated an important role for T cells in various drug-induced diseases. A detailed analysis of patients with various drug allergies revealed the existence of drug-specific T cells in the circulation or in eluate from skin i …
In recent years, increasing evidence has indicated an important role for T cells in various drug-induced diseases. A detailed analysi …
Werner syndrome presenting as early-onset diabetes: A case report.
Wang X, Liu S, Qin F, Liu Q, Wang Q. Wang X, et al. J Diabetes Investig. 2022 Mar;13(3):592-598. doi: 10.1111/jdi.13682. Epub 2021 Oct 27. J Diabetes Investig. 2022. PMID: 34564935 Free PMC article.
Werner syndrome is a rare autosomal recessive premature progeroid syndrome caused by mutations in the WRN gene. ...A novel heterozygous splice-site mutation in the WRN gene (c.1270-2A>T) was identified. The present case reminds clinicians that when young diabetes
Werner syndrome is a rare autosomal recessive premature progeroid syndrome caused by mutations in the WRN gene. ...A novel heterozygo
T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing.
Werner L, Dor C, Salamon N, Nagar M, Shouval DS. Werner L, et al. J Vis Exp. 2021 Jan 12;(167). doi: 10.3791/61792. J Vis Exp. 2021. PMID: 33522509
Immunological memory, the hallmark of adaptive immunity, is orchestrated by T and B lymphocytes. In circulation and different organs, there are billions of unique T and B cell clones, and each one can bind a specific antigen, leading to proliferation, differentiatio …
Immunological memory, the hallmark of adaptive immunity, is orchestrated by T and B lymphocytes. In circulation and different organs, …
Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting.
Seitz CM, Mittelstaet J, Atar D, Hau J, Reiter S, Illi C, Kieble V, Engert F, Drees B, Bender G, Krahl AC, Knopf P, Schroeder S, Paulsen N, Rokhvarguer A, Scheuermann S, Rapp E, Mast AS, Rabsteyn A, Schleicher S, Grote S, Schilbach K, Kneilling M, Pichler B, Lock D, Kotter B, Dapa S, Miltenyi S, Kaiser A, Lang P, Handgretinger R, Schlegel P. Seitz CM, et al. Oncoimmunology. 2021 Dec 2;10(1):2003532. doi: 10.1080/2162402X.2021.2003532. eCollection 2021. Oncoimmunology. 2021. PMID: 35686214 Free PMC article.
Chimeric antigen receptor (CAR)-T therapy holds great promise to sustainably improve cancer treatment. However, currently, a broad applicability of CAR-T cell therapies is hampered by limited CAR-T cell versatility and tractability and the lack of exclusive t …
Chimeric antigen receptor (CAR)-T therapy holds great promise to sustainably improve cancer treatment. However, currently, a broad ap …
1,664 results