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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 4
1982 6
1983 4
1984 8
1985 7
1986 6
1987 13
1988 24
1989 49
1990 71
1991 68
1992 96
1993 130
1994 157
1995 156
1996 171
1997 241
1998 250
1999 287
2000 366
2001 420
2002 595
2003 727
2004 878
2005 1085
2006 1306
2007 1487
2008 1738
2009 2114
2010 2379
2011 2789
2012 3209
2013 3647
2014 4370
2015 4933
2016 5362
2017 5751
2018 6807
2019 7829
2020 9259
2021 10882
2022 12458
2023 5912

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87,391 results

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Page 1
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.
Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W, Peng J, Zhang Z. Zheng C, et al. Cell. 2017 Jun 15;169(7):1342-1356.e16. doi: 10.1016/j.cell.2017.05.035. Cell. 2017. PMID: 28622514 Free article.
The transcriptional profiles of these individual cells, coupled with assembled T cell receptor (TCR) sequences, enable us to identify 11 T cell subsets based on their molecular and functional properties and delineate their developmental trajectory. ...One of the gen …
The transcriptional profiles of these individual cells, coupled with assembled T cell receptor (TCR) sequences, enable us to identify …
Engineering CAR-T cells.
Zhang C, Liu J, Zhong JF, Zhang X. Zhang C, et al. Biomark Res. 2017 Jun 24;5:22. doi: 10.1186/s40364-017-0102-y. eCollection 2017. Biomark Res. 2017. PMID: 28652918 Free PMC article. Review.
Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cell …
Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignanci …
T Cells in Fibrosis and Fibrotic Diseases.
Zhang M, Zhang S. Zhang M, et al. Front Immunol. 2020 Jun 26;11:1142. doi: 10.3389/fimmu.2020.01142. eCollection 2020. Front Immunol. 2020. PMID: 32676074 Free PMC article. Review.
Although the roles of macrophages in fibrogenesis have been studied for many years, the underlying mechanisms concerning the manner in which T cells regulate fibrosis are not completely understood. The T cell receptor (TCR) engages the antigen and shapes the reperto …
Although the roles of macrophages in fibrogenesis have been studied for many years, the underlying mechanisms concerning the manner in which …
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Zhang L, Yu X, Zheng L, Zhang Y, Li Y, Fang Q, Gao R, Kang B, Zhang Q, Huang JY, Konno H, Guo X, Ye Y, Gao S, Wang S, Hu X, Ren X, Shen Z, Ouyang W, Zhang Z. Zhang L, et al. Nature. 2018 Dec;564(7735):268-272. doi: 10.1038/s41586-018-0694-x. Epub 2018 Oct 29. Nature. 2018. PMID: 30479382
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T cells within tumours, remain unknown. ...Of the CD4(+) T cells, most tumour-infiltrating T regulatory (T(reg)) cel …
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T …
The Application of Nanobody in CAR-T Therapy.
Bao C, Gao Q, Li LL, Han L, Zhang B, Ding Y, Song Z, Zhang R, Zhang J, Wu XH. Bao C, et al. Biomolecules. 2021 Feb 8;11(2):238. doi: 10.3390/biom11020238. Biomolecules. 2021. PMID: 33567640 Free PMC article. Review.
After being transduced in Jurkat cells, natural killer cells, or primary T cells, the resulting nanobody-based CAR-T or CAR-NK cells demonstrate anti-tumor effects both in vitro and in vivo. ...The application of nanobodies in CAR-T therapy has been well demo …
After being transduced in Jurkat cells, natural killer cells, or primary T cells, the resulting nanobody-based CAR-T or CAR-NK …
TH1/TH2 cell differentiation and molecular signals.
Zhang Y, Zhang Y, Gu W, Sun B. Zhang Y, et al. Adv Exp Med Biol. 2014;841:15-44. doi: 10.1007/978-94-017-9487-9_2. Adv Exp Med Biol. 2014. PMID: 25261203 Review.
In vitro induction models, the major determinants of the cytokines present during the T-cell receptor (TCR)-mediated activation process. IL-12 and IFN-gamma make Naive CD4+ T cells highly express T-bet and STAT4 and differentiate to TH1 cells, while IL-4 make …
In vitro induction models, the major determinants of the cytokines present during the T-cell receptor (TCR)-mediated activation proce …
Broadly neutralizing antibody-derived CAR T cells reduce viral reservoir in individuals infected with HIV-1.
Liu B, Zhang W, Xia B, Jing S, Du Y, Zou F, Li R, Lu L, Chen S, Li Y, Hu Q, Lin Y, Zhang Y, He Z, Zhang X, Chen X, Peng T, Tang X, Cai W, Pan T, Li L, Zhang H. Liu B, et al. J Clin Invest. 2021 Oct 1;131(19):e150211. doi: 10.1172/JCI150211. J Clin Invest. 2021. PMID: 34375315 Free PMC article. Clinical Trial.
BACKGROUNDChimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. ...Notably, the cell-associated viral RNA and intact proviruses decreased significantly after CAR T cell treatment. Analyses of HIV-1 variants before or after CA …
BACKGROUNDChimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. ...Notably, the cell-associa …
Toxoplasma gondii secretory proteins and their role in invasion and pathogenesis.
Zhang Y, Lai BS, Juhas M, Zhang Y. Zhang Y, et al. Microbiol Res. 2019 Oct;227:126293. doi: 10.1016/j.micres.2019.06.003. Epub 2019 Jun 17. Microbiol Res. 2019. PMID: 31421715 Free article. Review.
T. gondii is a major opportunistic pathogen chronically infecting nearly one third of the world's population. ...T. gondii utilizes specialized secretory proteins to modify host cellular factors and facilitate invasion and replication. ...
T. gondii is a major opportunistic pathogen chronically infecting nearly one third of the world's population. ...T. gondii uti …
Novel Immunotherapies for Osteosarcoma.
Lu Y, Zhang J, Chen Y, Kang Y, Liao Z, He Y, Zhang C. Lu Y, et al. Front Oncol. 2022 Apr 1;12:830546. doi: 10.3389/fonc.2022.830546. eCollection 2022. Front Oncol. 2022. PMID: 35433427 Free PMC article. Review.
Tertiary lymphoid structure and decreased CD8+ T cell infiltration in minimally invasive adenocarcinoma.
Wang J, Jiang D, Zheng X, Li W, Zhao T, Wang D, Yu H, Sun D, Li Z, Zhang J, Zhang Z, Hou L, Jiang G, Fei K, Zhang F, Yang K, Zhang P. Wang J, et al. iScience. 2022 Feb 9;25(3):103883. doi: 10.1016/j.isci.2022.103883. eCollection 2022 Mar 18. iScience. 2022. PMID: 35243243 Free PMC article.
MIA tumors exhibited an adaptive TME characterized by high CD4(+) T cell infiltration, high B-cell activation, and low CD8(+) T cell infiltration. The high expression of markers for B cells, activated CD4(+) T cells, and follicular helper T (Tfh) cells …
MIA tumors exhibited an adaptive TME characterized by high CD4(+) T cell infiltration, high B-cell activation, and low CD8(+) T …
87,391 results
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