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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2006 1
2010 3
2011 6
2012 5
2013 5
2014 3
2015 3
2016 5
2017 2
2018 2
2019 4
2020 5
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44 results
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Page 1
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP. Matyskiela ME, et al. Among authors: Ito T. Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611. Epub 2016 Jun 22. Nature. 2016. PMID: 27338790
[Recent topics in IMiDs and cereblon].
Ito T, Handa H. Ito T, et al. Rinsho Ketsueki. 2017;58(10):2067-2073. doi: 10.11406/rinketsu.58.2067. Rinsho Ketsueki. 2017. PMID: 28978850 Japanese.
Structural basis of thalidomide enantiomer binding to cereblon.
Mori T, Ito T, Liu S, Ando H, Sakamoto S, Yamaguchi Y, Tokunaga E, Shibata N, Handa H, Hakoshima T. Mori T, et al. Among authors: Ito T. Sci Rep. 2018 Jan 22;8(1):1294. doi: 10.1038/s41598-018-19202-7. Sci Rep. 2018. PMID: 29358579 Free PMC article.
NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation.
Kimura A, Kitajima M, Nishida K, Serada S, Fujimoto M, Naka T, Fujii-Kuriyama Y, Sakamato S, Ito T, Handa H, Tanaka T, Yoshimura A, Suzuki H. Kimura A, et al. Among authors: Ito T. J Exp Med. 2018 Aug 6;215(8):2197-2209. doi: 10.1084/jem.20172024. Epub 2018 Jun 22. J Exp Med. 2018. PMID: 29934320 Free PMC article.
[Cereblon as a primary target of IMiDs].
Ito T, Handa H. Ito T, et al. Rinsho Ketsueki. 2019;60(9):1013-1019. doi: 10.11406/rinketsu.60.1013. Rinsho Ketsueki. 2019. PMID: 31597822 Review. Japanese.
Molecular mechanisms of cereblon-based drugs.
Asatsuma-Okumura T, Ito T, Handa H. Asatsuma-Okumura T, et al. Among authors: Ito T. Pharmacol Ther. 2019 Oct;202:132-139. doi: 10.1016/j.pharmthera.2019.06.004. Epub 2019 Jun 14. Pharmacol Ther. 2019. PMID: 31202702 Review.
Myeloid disease: Another action of a thalidomide derivative.
Ito T, Handa H. Ito T, et al. Nature. 2015 Jul 9;523(7559):167-8. doi: 10.1038/nature14628. Epub 2015 Jul 1. Nature. 2015. PMID: 26131932 No abstract available.
[Discovery of the target for immunomodulatory drugs (IMiDs)].
Ito T, Ando H, Handa H. Ito T, et al. Rinsho Ketsueki. 2016 May;57(5):556-62. doi: 10.11406/rinketsu.57.556. Rinsho Ketsueki. 2016. PMID: 27263779 Japanese.
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