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Page 1
An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state.
Ritt DA, Durrant DE, Drew MR, Sandin SI, Martinez Fiesco JA, Zhang X, Aydin F, Carpenter TS, Scheidemantle GM, D'Ippolito RA, Sohn AL, DeHart CJ, Shrestha R, Snead K, Hull J, Tempkin JOB, Yang Y, Lightstone FC, Streitz FH, Zhang P, Turbyville TJ, Stephen AG, Esposito D, Ingólfsson HI, Nissley DV, Morrison DK. Ritt DA, et al. Among authors: tempkin job. Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2508169122. doi: 10.1073/pnas.2508169122. Epub 2025 Sep 15. Proc Natl Acad Sci U S A. 2025. PMID: 40953270 Free PMC article.
A quantitative map of nuclear pore assembly reveals two distinct mechanisms.
Otsuka S, Tempkin JOB, Zhang W, Politi AZ, Rybina A, Hossain MJ, Kueblbeck M, Callegari A, Koch B, Morero NR, Sali A, Ellenberg J. Otsuka S, et al. Among authors: tempkin job. Nature. 2023 Jan;613(7944):575-581. doi: 10.1038/s41586-022-05528-w. Epub 2023 Jan 4. Nature. 2023. PMID: 36599981 Free PMC article.
Generating Protein Structures for Pathway Discovery Using Deep Learning.
Georgouli K, Stephany RR, Tempkin JOB, Santiago C, Aydin F, Heimann MA, Pottier L, Zhang X, Carpenter TS, Hsu T, Nissley DV, Streitz FH, Lightstone FC, Ingolfsson HI, Bremer PT. Georgouli K, et al. Among authors: tempkin job. J Chem Theory Comput. 2024 Oct 22;20(20):8795-8806. doi: 10.1021/acs.jctc.4c00816. Epub 2024 Oct 10. J Chem Theory Comput. 2024. PMID: 39388723 Free PMC article.
Integrative spatiotemporal modeling of biomolecular processes: application to the assembly of the Nuclear Pore Complex.
Latham AP, Tempkin JOB, Otsuka S, Zhang W, Ellenberg J, Sali A. Latham AP, et al. Among authors: tempkin job. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606842. doi: 10.1101/2024.08.06.606842. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2415674122. doi: 10.1073/pnas.2415674122. PMID: 39149317 Free PMC article. Updated. Preprint.
Free Energy and Flexibility Analysis of Autoinhibited Human BRAF.
Tempkin JOB, Aydin F, Essiz S, Yang Y, Carpenter TS, Durrant DE, Morrison DK, Ingólfsson HI, Streitz FH, Nissely DV, Lightstone FC, Zhang X. Tempkin JOB, et al. J Chem Inf Model. 2026 May 11;66(9):5372-5381. doi: 10.1021/acs.jcim.5c03126. Epub 2026 Apr 21. J Chem Inf Model. 2026. PMID: 42013449 Free PMC article.
Trajectory stratification of stochastic dynamics.
Dinner AR, Mattingly JC, Tempkin JOB, Van Koten B, Weare J. Dinner AR, et al. Among authors: tempkin job. SIAM Rev Soc Ind Appl Math. 2018;60(4):909-938. doi: 10.1137/16M1104329. Epub 2018 Nov 8. SIAM Rev Soc Ind Appl Math. 2018. PMID: 34650314 Free PMC article.
KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics.
Georgouli K, Tempkin JOB, Stanton LG, Oppelstrup T, Shrestha R, Carpenter TS, Aydin F, Zhang X, Bhatia H, Yang Y, Van QN, Bonilla PA, Gulten G, Goswami D, Di Natale F, Chavez JR, Moon JY, Dharuman G, Hengartner NW, Simanshu DK, Tran TH, Nguyen K, Stanley CB, Van Essen B, Bremer PT, Lightstone FC, Stephen AG, Glosli JN, Gnanakaran S, Turbyville TJ, McCormick F, Nissley DV, Streitz FH, Ingólfsson HI. Georgouli K, et al. Among authors: tempkin job. J Biol Chem. 2026 Mar;302(3):111237. doi: 10.1016/j.jbc.2026.111237. Epub 2026 Feb 4. J Biol Chem. 2026. PMID: 41651414 Free PMC article.
15 results