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Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue.
Felger JC, Alagbe O, Pace TW, Woolwine BJ, Hu F, Raison CL, Miller AH. Felger JC, et al. Brain Behav Immun. 2011 Aug;25(6):1094-8. doi: 10.1016/j.bbi.2011.02.015. Epub 2011 Feb 26. Brain Behav Immun. 2011. PMID: 21356304 Free PMC article. Clinical Trial.
Increases in the percentage of p-p38-positive lymphocytes following the first IFN-alpha injection also highly correlated with depression severity at weeks 4 (r=0.85, p=0.001) and 12 (r=0.70, p=0.018). Similar relationships were observed for fatigue. Examination of r …
Increases in the percentage of p-p38-positive lymphocytes following the first IFN-alpha injection also highly correlated with depression sev …
Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue.
Felger JC, Cole SW, Pace TW, Hu F, Woolwine BJ, Doho GH, Raison CL, Miller AH. Felger JC, et al. Psychol Med. 2012 Aug;42(8):1591-603. doi: 10.1017/S0033291711002868. Epub 2011 Dec 9. Psychol Med. 2012. PMID: 22152193 Free PMC article. Clinical Trial.
Of the up-regulated genes, 2'-5'-oligoadenylate synthetase 2 (OAS2), a gene linked to chronic fatigue syndrome (CFS), was the only gene that was differentially expressed in patients with IFN-alpha-induced depression/fatigue, and correlated with depression and fatigue scores at 12 …
Of the up-regulated genes, 2'-5'-oligoadenylate synthetase 2 (OAS2), a gene linked to chronic fatigue syndrome (CFS), was the only gene that …