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Page 1
Review on uremic toxins: classification, concentration, and interindividual variability.
Vanholder R, De Smet R, Glorieux G, Argilés A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jörres A, Lemke HD, Massy ZA, Passlick-Deetjen J, Rodriguez M, Stegmayr B, Stenvinkel P, Tetta C, Wanner C, Zidek W; European Uremic Toxin Work Group (EUTox). Vanholder R, et al. Kidney Int. 2003 May;63(5):1934-43. doi: 10.1046/j.1523-1755.2003.00924.x. Kidney Int. 2003. PMID: 12675874 Free article. Review.
BACKGROUND: The choice of the correct concentration of potential uremic toxins for in vitro, ex vivo, and in vivo experiments remains a major area of concern; errors at this level might result in incorrect decisions regarding therpeutic correction of uremia and rela …
BACKGROUND: The choice of the correct concentration of potential uremic toxins for in vitro, ex vivo, and in vivo experiments …
A history of uraemic toxicity and of the European Uraemic Toxin Work Group (EUTox).
Vanholder R, Argilés A, Jankowski J; European Uraemic Toxin Work Group (EUTox). Vanholder R, et al. Clin Kidney J. 2021 Jan 24;14(6):1514-1523. doi: 10.1093/ckj/sfab011. eCollection 2021 Jun. Clin Kidney J. 2021. PMID: 34413975 Free PMC article.
This picture is to a significant extent defined by retention of metabolites and peptides that with a preserved kidney function are excreted or degraded by the kidneys. In as far as those solutes have a negative biological/biochemical impact, they are called uraemic
This picture is to a significant extent defined by retention of metabolites and peptides that with a preserved kidney function are excreted …
A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients.
Sternkopf M, Thoröe-Boveleth S, Beck T, Oleschko K, Erlenkötter A, Tschulena U, Steppan S, Speer T, Goettsch C, Jankowski V, Jankowski J, Noels H; European Uremic Toxin Work Group-EUTox. Sternkopf M, et al. Toxins (Basel). 2019 Jul 3;11(7):389. doi: 10.3390/toxins11070389. Toxins (Basel). 2019. PMID: 31277311 Free PMC article.
Hydrophobic uremic toxins accumulate in patients with chronic kidney disease, contributing to a highly increased cardiovascular risk. ...The adsorption capacity was quantified using analytical chromatography after perfusion of the particles with an albumin solution …
Hydrophobic uremic toxins accumulate in patients with chronic kidney disease, contributing to a highly increased cardiovascula …
Review on uraemic solutes II--variability in reported concentrations: causes and consequences.
Vanholder R, Meert N, Schepers E, Glorieux G, Argiles A, Brunet P, Cohen G, Drüeke T, Mischak H, Spasovski G, Massy Z, Jankowski J; European Uremic Toxin Work Group (EUTox). Vanholder R, et al. Nephrol Dial Transplant. 2007 Nov;22(11):3115-21. doi: 10.1093/ndt/gfm151. Epub 2007 Jun 5. Nephrol Dial Transplant. 2007. PMID: 17550927 Review.
The aim of this manuscript is to initiate a constructive discussion about deviations in measured concentrations of uraemic solutes; these deviations, if not perceived or handled appropriately, may lead to incorrect interpretations of the pathophysiological role of uraem
The aim of this manuscript is to initiate a constructive discussion about deviations in measured concentrations of uraemic solutes; t …
Modulation of NADPH oxidase activity by known uraemic retention solutes.
Schulz AM, Terne C, Jankowski V, Cohen G, Schaefer M, Boehringer F, Tepel M, Kunkel D, Zidek W, Jankowski J; European Uremic Toxin Work Group (EUTox). Schulz AM, et al. Eur J Clin Invest. 2014 Aug;44(8):802-11. doi: 10.1111/eci.12297. Eur J Clin Invest. 2014. PMID: 25041433
Furthermore, the leucocytes were lysed and incubated in the presence of uraemic retention solute of interest and diphenyleneiodonium chloride (DPI), an inhibitor of NADPH oxidase. ...Oxalate has been characterized as the strongest inhibitor of NADPH oxidase (90% of DPI inh …
Furthermore, the leucocytes were lysed and incubated in the presence of uraemic retention solute of interest and diphenyleneiodonium …
Review on uraemic toxins III: recommendations for handling uraemic retention solutes in vitro--towards a standardized approach for research on uraemia.
Cohen G, Glorieux G, Thornalley P, Schepers E, Meert N, Jankowski J, Jankowski V, Argiles A, Anderstam B, Brunet P, Cerini C, Dou L, Deppisch R, Marescau B, Massy Z, Perna A, Raupachova J, Rodriguez M, Stegmayr B, Vanholder R, Hörl WH; European Uremic Toxin Work Group (EUTox). Cohen G, et al. Nephrol Dial Transplant. 2007 Dec;22(12):3381-90. doi: 10.1093/ndt/gfm210. Epub 2007 Aug 27. Nephrol Dial Transplant. 2007. PMID: 17724037 Review. No abstract available.
The clinical impact of plasma leptin levels in a cohort of chronic kidney disease patients.
de Oliveira RB, Liabeuf S, Okazaki H, Lenglet A, Desjardins L, Lemke HD, Vanholder R, Choukroun G, Massy ZA; European Uremic Toxin Work Group (EUTox). de Oliveira RB, et al. Clin Kidney J. 2013 Feb;6(1):63-70. doi: 10.1093/ckj/sfs176. Epub 2012 Jan 1. Clin Kidney J. 2013. PMID: 27818752 Free PMC article.
The results of animal and clinical studies have revealed a positive relationship between leptin and vascular smooth muscle cell counts and calcification, arterial rigidity, carotid thickness and the incidence of CVD. However, despite leptin fulfilling the definition of a uremi
The results of animal and clinical studies have revealed a positive relationship between leptin and vascular smooth muscle cell counts and c …
Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.
Schepers E, Barreto DV, Liabeuf S, Glorieux G, Eloot S, Barreto FC, Massy Z, Vanholder R; European Uremic Toxin Work Group (EUTox). Schepers E, et al. Clin J Am Soc Nephrol. 2011 Oct;6(10):2374-83. doi: 10.2215/CJN.01720211. Epub 2011 Aug 4. Clin J Am Soc Nephrol. 2011. PMID: 21817129 Free PMC article.
Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients.
Barreto FC, Barreto DV, Liabeuf S, Meert N, Glorieux G, Temmar M, Choukroun G, Vanholder R, Massy ZA; European Uremic Toxin Work Group (EUTox). Barreto FC, et al. Clin J Am Soc Nephrol. 2009 Oct;4(10):1551-8. doi: 10.2215/CJN.03980609. Epub 2009 Aug 20. Clin J Am Soc Nephrol. 2009. PMID: 19696217 Free PMC article.
BACKGROUND AND OBJECTIVES: As a major component of uremic syndrome, cardiovascular disease is largely responsible for the high mortality observed in chronic kidney disease (CKD). Preclinical studies have evidenced an association between serum levels of indoxyl sulfate (IS, …
BACKGROUND AND OBJECTIVES: As a major component of uremic syndrome, cardiovascular disease is largely responsible for the high mortal …
Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients.
Fourdinier O, Schepers E, Metzinger-Le Meuth V, Glorieux G, Liabeuf S, Verbeke F, Vanholder R, Brigant B, Pletinck A, Diouf M, Burtey S, Choukroun G, Massy ZA, Metzinger L; European Uremic Toxin Work Group-EUTox. Fourdinier O, et al. Sci Rep. 2019 Mar 14;9(1):4477. doi: 10.1038/s41598-019-41101-8. Sci Rep. 2019. PMID: 30872798 Free PMC article.
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