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Year Number of Results
2010 2
2015 1
2016 2
2019 3
2021 3
2022 3
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Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer.
Obradovic A, Graves D, Korrer M, Wang Y, Roy S, Naveed A, Xu Y, Luginbuhl A, Curry J, Gibson M, Idrees K, Hurley P, Jiang P, Liu XS, Uppaluri R, Drake CG, Califano A, Kim YJ. Obradovic A, et al. Clin Cancer Res. 2022 May 13;28(10):2094-2109. doi: 10.1158/1078-0432.CCR-21-3570. Clin Cancer Res. 2022. PMID: 35262677
Functionally, HNCAF-0/3 were found to reduce TGFbeta-dependent PD-1+TIM-3+ exhaustion of CD8 T cells, increase CD103+NKG2A+ resident memory phenotypes, and enhance the overall cytolytic profile of T cells. ...
Functionally, HNCAF-0/3 were found to reduce TGFbeta-dependent PD-1+TIM-3+ exhaustion of CD8 T cells, increase CD103+NKG2A+ resident …
Combined Next-generation Sequencing and Flow Cytometry Analysis for an Anti-PD-L1 Partial Responder over Time: An Exploration of Mechanisms of PD-L1 Activity and Resistance in Bladder Cancer.
Kates M, Nirschl TR, Baras AS, Sopko NA, Hahn NM, Su X, Zhang J, Kochel CM, Choi W, McConkey DJ, Drake CG, Bivalacqua TJ. Kates M, et al. Eur Urol Oncol. 2021 Feb;4(1):117-120. doi: 10.1016/j.euo.2019.01.017. Epub 2019 Feb 26. Eur Urol Oncol. 2021. PMID: 31411999
We found that as the tumor became more resistant to anti-PD-L1, the proportion of regulatory T cells and CD8(+) T cells expressing alternative immune checkpoints including CTLA-4, TIM-3, and LAG-3 increased. This suggests that alternative immune checkpoint upregulation may …
We found that as the tumor became more resistant to anti-PD-L1, the proportion of regulatory T cells and CD8(+) T cells expressing alternati …
Combinatorial Herpes Simplex Vaccine Strategies: From Bedside to Bench and Back.
Chentoufi AA, Dhanushkodi NR, Srivastava R, Prakash S, Coulon PA, Zayou L, Vahed H, Chentoufi HA, Hormi-Carver KK, BenMohamed L. Chentoufi AA, et al. Front Immunol. 2022 Apr 25;13:849515. doi: 10.3389/fimmu.2022.849515. eCollection 2022. Front Immunol. 2022. PMID: 35547736 Free PMC article. Review.
In addition, we reported that a combination of prime/pull vaccine approach with approaches to reverse T cell exhaustion led to even better protection against herpes infection and disease. Blocking PD-1, LAG-3, TIGIT and/or TIM-3 immune checkpoint pathways helped in restori …
In addition, we reported that a combination of prime/pull vaccine approach with approaches to reverse T cell exhaustion led to even better p …
Natalizumab plus interferon beta-1a reduces lesion formation in relapsing multiple sclerosis.
Radue EW, Stuart WH, Calabresi PA, Confavreux C, Galetta SL, Rudick RA, Lublin FD, Weinstock-Guttman B, Wynn DR, Fisher E, Papadopoulou A, Lynn F, Panzara MA, Sandrock AW; SENTINEL Investigators. Radue EW, et al. J Neurol Sci. 2010 May 15;292(1-2):28-35. doi: 10.1016/j.jns.2010.02.012. Epub 2010 Mar 16. J Neurol Sci. 2010. PMID: 20236661 Clinical Trial.
Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
Le DT, Wang-Gillam A, Picozzi V, Greten TF, Crocenzi T, Springett G, Morse M, Zeh H, Cohen D, Fine RL, Onners B, Uram JN, Laheru DA, Lutz ER, Solt S, Murphy AL, Skoble J, Lemmens E, Grous J, Dubensky T Jr, Brockstedt DG, Jaffee EM. Le DT, et al. J Clin Oncol. 2015 Apr 20;33(12):1325-33. doi: 10.1200/JCO.2014.57.4244. Epub 2015 Jan 12. J Clin Oncol. 2015. PMID: 25584002 Free PMC article. Clinical Trial.
The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits.
Srivastava R, Dervillez X, Khan AA, Chentoufi AA, Chilukuri S, Shukr N, Fazli Y, Ong NN, Afifi RE, Osorio N, Geertsema R, Nesburn AB, Wechsler SL, BenMohamed L. Srivastava R, et al. J Virol. 2016 Mar 28;90(8):3913-3928. doi: 10.1128/JVI.02450-15. Print 2016 Apr. J Virol. 2016. PMID: 26842468 Free PMC article.
Persistent pathogens, such as herpes simplex virus 1 (HSV-1), have evolved a variety of immune evasion strategies to avoid being detected and destroyed by the host's immune system. A dynamic cross talk appears to occur between the HSV-1 latency-associated transcript (LAT), …
Persistent pathogens, such as herpes simplex virus 1 (HSV-1), have evolved a variety of immune evasion strategies to avoid being detected an …
12 results