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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1963 1
1964 4
1965 1
1966 2
1967 2
1968 1
1969 1
1971 1
1973 2
1974 5
1975 2
1976 4
1977 10
1978 6
1979 10
1980 5
1981 4
1982 5
1983 4
1984 3
1985 3
1986 5
1987 7
1988 32
1989 56
1990 20
1991 18
1992 20
1993 21
1994 26
1995 31
1996 59
1997 76
1998 110
1999 121
2000 156
2001 154
2002 200
2003 210
2004 262
2005 265
2006 300
2007 344
2008 374
2009 357
2010 405
2011 508
2012 473
2013 530
2014 590
2015 814
2016 882
2017 909
2018 991
2019 1032
2020 1132
2021 117
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10,528 results
Results by year
Filters applied: . Clear all The following term was not found in PubMed: Napier-Munn
Page 1
Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-kappaB/TNF-alpha pathway.
Yang H, Xie T, Li D, Du X, Wang T, Li C, Song X, Xu L, Yi F, Liang X, Gao L, Yang X, Ma C. Yang H, et al. Mol Metab. 2019 May;23:24-36. doi: 10.1016/j.molmet.2019.02.007. Epub 2019 Feb 26. Mol Metab. 2019. PMID: 30862474 Free PMC article.
METHODS: We downregulated Tim-3 expression in kidney (intrarenal injection of Tim-3 shRNA expressing lentivirus or global Tim-3 knockout mice) and induced DN by streptozotocin (STZ). ...Similar effects were observed in mice with Tim-3 knockdown diabeti …
METHODS: We downregulated Tim-3 expression in kidney (intrarenal injection of Tim-3 shRNA expressing lentivirus or global T
TIM-3, a promising target for cancer immunotherapy.
He Y, Cao J, Zhao C, Li X, Zhou C, Hirsch FR. He Y, et al. Onco Targets Ther. 2018 Oct 16;11:7005-7009. doi: 10.2147/OTT.S170385. eCollection 2018. Onco Targets Ther. 2018. PMID: 30410357 Free PMC article. Review.
Recent studies have highlighted that TIM-3 has an important role to play in T-cell exhaustion and correlates with the outcome of anti-PD-1 therapy. Targeting TIM-3 might be a promising approach for cancer immunotherapy. Here, we review the role of TIM-3 in ca …
Recent studies have highlighted that TIM-3 has an important role to play in T-cell exhaustion and correlates with the outcome of anti …
CoViD-19 Immunopathology and Immunotherapy.
Chiappelli F, Khakshooy A, Greenberg G. Chiappelli F, et al. Bioinformation. 2020 Mar 31;16(3):219-222. doi: 10.6026/97320630016219. eCollection 2020. Bioinformation. 2020. PMID: 32308263 Free PMC article.
Flow cytometry established a progressive increase in the expression of programmed cell death marker-1 (PD-1) and T cell immunoglobulin and mucin domain 3 (Tim-3) as patients (n=14) deteriorated from prodromal to symptomatic CoViD-19 requiring intensive care. ...
Flow cytometry established a progressive increase in the expression of programmed cell death marker-1 (PD-1) and T cell immunoglobulin and m …
Overexpression of TIM-3 in Macrophages Aggravates Pathogenesis of Pulmonary Fibrosis in Mice.
Wang Y, Kuai Q, Gao F, Wang Y, He M, Zhou H, Han G, Jiang X, Ren S, Yu Q. Wang Y, et al. Am J Respir Cell Mol Biol. 2019 Dec;61(6):727-736. doi: 10.1165/rcmb.2019-0070OC. Am J Respir Cell Mol Biol. 2019. PMID: 31162951
Lung pathology and profibrotic molecules were assessed in a bleomycin (BLM)-induced pulmonary fibrosis model using wild-type (WT) and TIM-3 transgenic (TIM-3-TG) mice. Macrophage cells, RAW264.7, were then applied to investigate the effect of macrophage TIM-3 …
Lung pathology and profibrotic molecules were assessed in a bleomycin (BLM)-induced pulmonary fibrosis model using wild-type (WT) and TIM
Tim-3 fosters HCC development by enhancing TGF-beta-mediated alternative activation of macrophages.
Yan W, Liu X, Ma H, Zhang H, Song X, Gao L, Liang X, Ma C. Yan W, et al. Gut. 2015 Oct;64(10):1593-604. doi: 10.1136/gutjnl-2014-307671. Epub 2015 Jan 21. Gut. 2015. PMID: 25608525
Blocking interleukin 6 reversed the Tim-3-mediated effects on HCC cell growth in vitro. CONCLUSIONS: Tim-3 displays critical roles in microenvironment-induced activation and protumoral effects of TAMs in HCC. Interference of Tim-3 might be great potential in …
Blocking interleukin 6 reversed the Tim-3-mediated effects on HCC cell growth in vitro. CONCLUSIONS: Tim-3 displays critical r …
TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.
Tomkowicz B, Walsh E, Cotty A, Verona R, Sabins N, Kaplan F, Santulli-Marotto S, Chin CN, Mooney J, Lingham RB, Naso M, McCabe T. Tomkowicz B, et al. PLoS One. 2015 Oct 22;10(10):e0140694. doi: 10.1371/journal.pone.0140694. eCollection 2015. PLoS One. 2015. PMID: 26492563 Free PMC article.
TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells. ...To begin to address this discrepancy, we examined the effect of TIM-3 in
TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferen
Lipopolysaccharide mediates time-dependent macrophage M1/M2 polarization through the Tim-3/Galectin-9 signalling pathway.
Zhang W, Zhang Y, He Y, Wang X, Fang Q. Zhang W, et al. Exp Cell Res. 2019 Mar 15;376(2):124-132. doi: 10.1016/j.yexcr.2019.02.007. Epub 2019 Feb 11. Exp Cell Res. 2019. PMID: 30763585
However, the effects of Tim-3/Gal-9 signalling on M1/M2 macrophage polarization are unclear. ...M1/M2 phenotypic macrophage markers were measured 0, 1, 3, 6, 12, and 24 h after stimulation, alpha-lactose was used to inhibit Gal-9, anti-mouse Tim-3 antibody was used …
However, the effects of Tim-3/Gal-9 signalling on M1/M2 macrophage polarization are unclear. ...M1/M2 phenotypic macrophage markers w …
Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas.
Kim JE, Patel MA, Mangraviti A, Kim ES, Theodros D, Velarde E, Liu A, Sankey EW, Tam A, Xu H, Mathios D, Jackson CM, Harris-Bookman S, Garzon-Muvdi T, Sheu M, Martin AM, Tyler BM, Tran PT, Ye X, Olivi A, Taube JM, Burger PC, Drake CG, Brem H, Pardoll DM, Lim M. Kim JE, et al. Clin Cancer Res. 2017 Jan 1;23(1):124-136. doi: 10.1158/1078-0432.CCR-15-1535. Epub 2016 Jun 29. Clin Cancer Res. 2017. PMID: 27358487 Free PMC article.
EXPERIMENTAL DESIGN: C57BL/6 mice were implanted with murine glioma cell line GL261-luc2 and randomized into 8 treatment arms: (i) control, (ii) SRS, (iii) anti-PD-1 antibody, (iv) anti-TIM-3 antibody, (v) anti-PD-1 + SRS, (vi) anti-TIM-3 + SRS, (vii) anti-PD-1 + an …
EXPERIMENTAL DESIGN: C57BL/6 mice were implanted with murine glioma cell line GL261-luc2 and randomized into 8 treatment arms: (i) control, …
IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-kappaB.
Liu W, Wang H, Bai F, Ding L, Huang Y, Lu C, Chen S, Li C, Yue X, Liang X, Ma C, Xu L, Gao L. Liu W, et al. Cell Prolif. 2020 Mar;53(3):e12776. doi: 10.1111/cpr.12776. Epub 2020 Feb 5. Cell Prolif. 2020. PMID: 32020709 Free PMC article.
Both TIM-4 and IL-6 promoted migration, invasion and EMT of NSCLC cells. Interestingly, TIM-4 knockdown reversed the role of IL-6 in NSCLC and IL-6 promoted metastasis of NSCLC by up-regulating TIM-4 via NF-kappaB. ...
Both TIM-4 and IL-6 promoted migration, invasion and EMT of NSCLC cells. Interestingly, TIM-4 knockdown reversed the role of I …
Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.
Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC. Sabatos-Peyton CA, et al. Oncoimmunology. 2017 Nov 9;7(2):e1385690. doi: 10.1080/2162402X.2017.1385690. eCollection 2018. Oncoimmunology. 2017. PMID: 29308307 Free PMC article.
These observations raise the important question of which of these multiple receptor:ligand relationships must be blocked by an anti-Tim-3 antibody in order to achieve therapeutic efficacy. Here, we have examined the properties of anti-murine and anti-human Tim-3 ant …
These observations raise the important question of which of these multiple receptor:ligand relationships must be blocked by an anti-Tim
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