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Defining the Importance of Age-Related Changes in Drug Clearance to Optimizing Aminoglycoside Dosing Regimens for Adult Patients with Cystic Fibrosis.
Rohani R, Hoff B, Jain M, Philbrick A, Salama S, Cullina JF, Rhodes NJ. Rohani R, et al. Eur J Drug Metab Pharmacokinet. 2022 Mar;47(2):199-209. doi: 10.1007/s13318-021-00734-9. Epub 2021 Dec 9. Eur J Drug Metab Pharmacokinet. 2022. PMID: 34882292
METHODS: Adult CF patients admitted for pulmonary exacerbation, receiving at least 72 h of systemic gentamicin, tobramycin, or amikacin, with measured concentrations were included. Covariates [e.g., age, weight, creatinine clearance (CRCL)] were screened. ...
METHODS: Adult CF patients admitted for pulmonary exacerbation, receiving at least 72 h of systemic gentamicin, tobramycin, or amikac …
Exploring the Relationship between FEV1 Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies.
Hoff BM, Scheetz MH, Jain M, Cullina JF, Rhodes NJ. Hoff BM, et al. Pharmacotherapy. 2020 Jun;40(6):584-591. doi: 10.1002/phar.2399. Epub 2020 May 5. Pharmacotherapy. 2020. PMID: 32259317
METHODS: We conducted a retrospective study of adult CF patients treated with an intravenous aminoglycoside for a PEx. Serum amikacin, gentamicin, and tobramycin levels and forced expiratory volume over 1 second (FEV(1) ) data were used to evaluate exposure-response relati …
METHODS: We conducted a retrospective study of adult CF patients treated with an intravenous aminoglycoside for a PEx. Serum amikacin, genta …
Determination of aminoglycoside residues in milk and muscle based on a simple and fast extraction procedure followed by liquid chromatography coupled to tandem mass spectrometry and time of flight mass spectrometry.
Arsand JB, Jank L, Martins MT, Hoff RB, Barreto F, Pizzolato TM, Sirtori C. Arsand JB, et al. Talanta. 2016 Jul 1;154:38-45. doi: 10.1016/j.talanta.2016.03.045. Epub 2016 Mar 15. Talanta. 2016. PMID: 27154646 Free article.
This paper describes a fast and simple analytical method for the determination of ten aminoglycosides (spectinomycin, tobramycin, gentamicin, kanamycin, hygromycin, apramycin, streptomycin, dihydrostreptomycin, amikacin and neomycin) in bovine milk and bovine, swine and po …
This paper describes a fast and simple analytical method for the determination of ten aminoglycosides (spectinomycin, tobramycin, gen …
Thermodynamics of aminoglycoside and acyl-coenzyme A binding to the Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase.
Hegde SS, Dam TK, Brewer CF, Blanchard JS. Hegde SS, et al. Biochemistry. 2002 Jun 11;41(23):7519-27. doi: 10.1021/bi020190l. Biochemistry. 2002. PMID: 12044186
Association constants for different aminoglycosides varied greatly (4 x 10(4)-150 x 10(4)) while the association constants of several acyl-coenzyme A derivatives were similar (3.2 x 10(4)-4.5 x 10(4)). The association constants and van't Hoff enthalpy changes derived from …
Association constants for different aminoglycosides varied greatly (4 x 10(4)-150 x 10(4)) while the association constants of several acyl-c …