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Page 1
Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.
Perry TA, Deng Y, Hulley PA, Maciewicz RA, Mitchelmore J, Larsson S, Gogain J, Brachat S, Struglics A, Appleton CT, Kluzek S, Arden NK, Felson D, Bondi L, Kapoor M, Lohmander LS, Welting TJ, Walsh DA, Valdes AM, Jostins-Dean L, Watt FE, Tom BDM, Vincent TL; STEpUP OA Consortium. Perry TA, et al. Nat Commun. 2026 Jun 2;17(1):4721. doi: 10.1038/s41467-026-71632-4. Nat Commun. 2026. PMID: 42230587 Free PMC article.
Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium.
Deng Y, Perry TA, Hulley P, Maciewicz RA, Mitchelmore J, Perry D, Larsson S, Brachat S, Struglics A, Appleton CT, Kluzek S, Arden NK, Felson D, Marsden B, Tom BDM, Bondi L, Kapoor M, Batchelor V, Mackay-Alderson J, Kumar V, Lohmander LS, Welting TJ, Walsh DA, Valdes AM; STEpUP OA Consortium; Vincent TL, Watt FE, Jostins-Dean L. Deng Y, et al. Among authors: vincent tl. PLoS One. 2024 Nov 18;19(11):e0309677. doi: 10.1371/journal.pone.0309677. eCollection 2024. PLoS One. 2024. PMID: 39556578 Free PMC article.
Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis.
Zhu L, Kamalathevan P, Koneva LA, Zarebska JM, Chanalaris A, Ismail H, Wiberg A, Ng M, Muhammad H, Walsby-Tickle J, McCullagh JSO, Watt FE; Oxford Hand Surgical Team; Sansom SN, Furniss D, Gardiner MD, Vincent TL, Riley N, Spiteri M, McNab I, Little C, Cogswell L, Critchley P, Giele H, Shirley R. Zhu L, et al. Among authors: vincent tl. Sci Transl Med. 2022 Dec 21;14(676):eabm4054. doi: 10.1126/scitranslmed.abm4054. Epub 2022 Dec 21. Sci Transl Med. 2022. PMID: 36542696
84 results