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Showing results for tonic schmitz
Your search for Tonia Schmitz retrieved no results
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.
Schumann T, Ramon SC, Schubert N, Mayo MA, Hega M, Maser KI, Ada SR, Sydow L, Hajikazemi M, Badstübner M, Müller P, Ge Y, Shakeri F, Buness A, Rupf B, Lienenklaus S, Utess B, Muhandes L, Haase M, Rupp L, Schmitz M, Gramberg T, Manel N, Hartmann G, Zillinger T, Kato H, Bauer S, Gerbaulet A, Paeschke K, Roers A, Behrendt R. Schumann T, et al. J Exp Med. 2023 Jan 2;220(1):e20220829. doi: 10.1084/jem.20220829. Epub 2022 Nov 8. J Exp Med. 2023. PMID: 36346347 Free PMC article.
In these pathophysiological conditions, activation of the DNA sensor cGAS and IFN production are linked to spontaneous DNA damage. Physiological, or tonic, IFN signaling on the other hand is essential to functionally prime nucleic acid sensing pathways. ...Instead, we foun …
In these pathophysiological conditions, activation of the DNA sensor cGAS and IFN production are linked to spontaneous DNA damage. Physiolog …
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T. Wilke AC, et al. Blood. 2022 Jan 27;139(4):538-553. doi: 10.1182/blood.2021012081. Blood. 2022. PMID: 34624079 Free PMC article.
Mechanistically, SHMT2 inhibition led to a significant reduction of intracellular glycine and formate levels, which inhibited the mTOR pathway and thereby triggered autophagic degradation of the oncogenic transcription factor TCF3. Consequently, this led to a collapse of tonic …
Mechanistically, SHMT2 inhibition led to a significant reduction of intracellular glycine and formate levels, which inhibited the mTOR pathw …
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Schmitz R, et al. Nature. 2012 Oct 4;490(7418):116-20. doi: 10.1038/nature11378. Epub 2012 Aug 12. Nature. 2012. PMID: 22885699 Free PMC article.
TCF3 activated the pro-survival phosphatidylinositol-3-OH kinase pathway in BL, in part by augmenting tonic B-cell receptor signalling. In 38% of sporadic BL cases, oncogenic CCND3 mutations produced highly stable cyclin D3 isoforms that drive cell cycle progression. ...
TCF3 activated the pro-survival phosphatidylinositol-3-OH kinase pathway in BL, in part by augmenting tonic B-cell receptor signallin …
Oncogenic mechanisms in Burkitt lymphoma.
Schmitz R, Ceribelli M, Pittaluga S, Wright G, Staudt LM. Schmitz R, et al. Cold Spring Harb Perspect Med. 2014 Feb 1;4(2):a014282. doi: 10.1101/cshperspect.a014282. Cold Spring Harb Perspect Med. 2014. PMID: 24492847 Free PMC article. Review.
Within the germinal center, TCF-3 up-regulates genes that are characteristically expressed in the rapidly dividing centroblasts, the putative cell of origin for Burkitt lymphoma, while repressing genes expressed in the less proliferative centrocytes. TCF-3 promotes antigen-indepe …
Within the germinal center, TCF-3 up-regulates genes that are characteristically expressed in the rapidly dividing centroblasts, the putativ …
The making of synaptic ribbons: how they are built and what they do.
Schmitz F. Schmitz F. Neuroscientist. 2009 Dec;15(6):611-24. doi: 10.1177/1073858409340253. Neuroscientist. 2009. PMID: 19700740 Review.
Ribbon synapses in the retina and inner ear maintain tonic neurotransmitter release at high rates to transduce a broad bandwidth of stimulus intensities. ...
Ribbon synapses in the retina and inner ear maintain tonic neurotransmitter release at high rates to transduce a broad bandwidth of s …
Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.
Schmitz F. Schmitz F. Front Mol Neurosci. 2014 Feb 6;7:3. doi: 10.3389/fnmol.2014.00003. eCollection 2014. Front Mol Neurosci. 2014. PMID: 24567702 Free PMC article. Review.
In the synaptic terminals, changes of intracellular Ca(2+) trigger various aspects of neurotransmission. Photoreceptors employ tonically active ribbon synapses that encode light-induced, graded changes of membrane potential into modulation of continuous synaptic vesicle ex …
In the synaptic terminals, changes of intracellular Ca(2+) trigger various aspects of neurotransmission. Photoreceptors employ tonically …
Evaluation of force feedback in walking using joint torques as "naturalistic" stimuli.
Zill SN, Dallmann CJ, S Szczecinski N, Büschges A, Schmitz J. Zill SN, et al. J Neurophysiol. 2021 Jul 1;126(1):227-248. doi: 10.1152/jn.00120.2021. Epub 2021 Jun 9. J Neurophysiol. 2021. PMID: 34107221 Free PMC article.
All sensilla directionally encoded the dynamics of force increases and showed hysteresis to transient force decreases. Smaller receptors exhibited more tonic firing. Our findings suggest that dynamic sensitivity in force feedback can modulate ongoing muscle activities to s …
All sensilla directionally encoded the dynamics of force increases and showed hysteresis to transient force decreases. Smaller receptors exh …
Declining malformation rates with changed antiepileptic drug prescribing: An observational study.
Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV, Vajda F; EURAP Study Group. Tomson T, et al. Neurology. 2019 Aug 27;93(9):e831-e840. doi: 10.1212/WNL.0000000000008001. Epub 2019 Aug 7. Neurology. 2019. PMID: 31391249
The Cochrane-Armitage linear trend analysis was used to assess changes in AED treatment, prevalence of MCMs, and occurrence of generalized tonic-clonic seizures (GTCs) over 3 time periods: 2000-2005 (n = 4,760), 2006-2009 (n = 3,599), and 2010-2013 (n = 2,949). ...
The Cochrane-Armitage linear trend analysis was used to assess changes in AED treatment, prevalence of MCMs, and occurrence of generalized …
Bupropion With Clozapine: Case Reports of Seizure After Coadministration.
Schmitz A, Botner B, Hund M. Schmitz A, et al. J Pharm Pract. 2021 Jun;34(3):497-502. doi: 10.1177/0897190020904280. Epub 2020 Feb 21. J Pharm Pract. 2021. PMID: 32079452
In the first case, a patient with schizoaffective disorder treated with dual antipsychotic therapy had a witnessed generalized tonic-clonic seizure. With the exception of bupropion/naltrexone which was started 2.5 months prior for weight loss, she had not had any recent me …
In the first case, a patient with schizoaffective disorder treated with dual antipsychotic therapy had a witnessed generalized tonic- …
Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses.
Dembla E, Dembla M, Maxeiner S, Schmitz F. Dembla E, et al. Sci Rep. 2020 Apr 6;10(1):5957. doi: 10.1038/s41598-020-62734-0. Sci Rep. 2020. PMID: 32249787 Free PMC article.
However, mean ribbon length and length of presynaptic Cav1.4/RIM2 clusters increased significantly during dark-adaptation when tonic exocytosis is highest. In the present study, we identified by the analyses of synaptic ribbon-deficient RIBEYE knockout mice that synaptic r …
However, mean ribbon length and length of presynaptic Cav1.4/RIM2 clusters increased significantly during dark-adaptation when tonic …
36 results