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5,099 results

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Page 1
Structure of V-ATPase from citrus fruit.
Tan YZ, Keon KA, Abdelaziz R, Imming P, Schulze W, Schumacher K, Rubinstein JL. Tan YZ, et al. Structure. 2022 Oct 6;30(10):1403-1410.e4. doi: 10.1016/j.str.2022.07.006. Epub 2022 Aug 29. Structure. 2022. PMID: 36041457 Free article.
Compared with yeast and mammalian enzymes, the membrane region of the plant V-ATPase lacks subunit f and possesses an unusual configuration of transmembrane alpha helices. Subunit H, which inhibits ATP hydrolysis in the isolated catalytic region of V-ATPase, adopts …
Compared with yeast and mammalian enzymes, the membrane region of the plant V-ATPase lacks subunit f and possesses an unusual configu …
A conserved ion channel function of STING mediates noncanonical autophagy and cell death.
Xun J, Zhang Z, Lv B, Lu D, Yang H, Shang G, Tan JX. Xun J, et al. EMBO Rep. 2024 Feb;25(2):544-569. doi: 10.1038/s44319-023-00045-x. Epub 2024 Jan 2. EMBO Rep. 2024. PMID: 38177926 Free PMC article.
STING also triggers noncanonical autophagy, involving LC3 lipidation on STING vesicles through the V-ATPase-ATG16L1 axis, as well as induces cell death. Although the proton pump V-ATPase senses organelle deacidification in other contexts, it is unclear how STING act …
STING also triggers noncanonical autophagy, involving LC3 lipidation on STING vesicles through the V-ATPase-ATG16L1 axis, as well as …
Hetero-core III-V/Si microlaser.
Lee CW, Ng DK, Tan AL, Wang Q. Lee CW, et al. Opt Lett. 2016 Jul 1;41(13):3149-52. doi: 10.1364/OL.41.003149. Opt Lett. 2016. PMID: 27367124
We design and demonstrate optically pumped microlasers with a hetero-core cavity formed by III-V and silicon-on-insulator (SOI) materials. Hetero-core cavities with identical lateral dimension are fabricated. The cavity is formed by III-V layer with thickness of 210 …
We design and demonstrate optically pumped microlasers with a hetero-core cavity formed by III-V and silicon-on-insulator (SOI) mater …
V-EMF therapy: A new painless and completely non-invasive treatment for striae gravidarum.
Veronese S, Bacci PA, Garcia-Gimenez V, Canel Micheloud CC, Haro García NL, Sbarbati A. Veronese S, et al. J Cosmet Dermatol. 2024 Jun;23(6):2007-2014. doi: 10.1111/jocd.16220. Epub 2024 Mar 28. J Cosmet Dermatol. 2024. PMID: 38549181
AIMS: The aim of this study was to evaluate the effectiveness of a treatment that applies an electromagnetic field under vacuum (V-EMF therapy) on the abdominal SG. METHODS: A retrospective analysis was conducted on the medical records of 26 women affected by abdominal SG …
AIMS: The aim of this study was to evaluate the effectiveness of a treatment that applies an electromagnetic field under vacuum (V-EM …
The Tanshinones (Tan) Extract From Salvia miltiorrhiza Bunge Induces ROS-Dependent Apoptosis in Pancreatic Cancer via AKT Hyperactivation-Mediated FOXO3/SOD2 Signaling.
Xu Q, Dong S, Gong Q, Dai Q, Cheng R, Ge Y. Xu Q, et al. Integr Cancer Ther. 2024 Jan-Dec;23:15347354241258961. doi: 10.1177/15347354241258961. Integr Cancer Ther. 2024. PMID: 38899834 Free PMC article.
OBJECTIVE: In this study, we aimed to investigate the therapeutic potential of Tan in pancreatic cancer and elucidate the underlying mechanisms. MATERIALS AND METHODS: The viabilities of PANC-1 and Bxpc-3 cells were determined by MTT assay, after treatment with various con …
OBJECTIVE: In this study, we aimed to investigate the therapeutic potential of Tan in pancreatic cancer and elucidate the underlying …
A novel and efficient tandem CD19- and CD22-directed CAR for B cell ALL.
Zanetti SR, Velasco-Hernandez T, Gutierrez-Agüera F, Díaz VM, Romecín PA, Roca-Ho H, Sánchez-Martínez D, Tirado N, Baroni ML, Petazzi P, Torres-Ruiz R, Molina O, Bataller A, Fuster JL, Ballerini P, Juan M, Jeremias I, Bueno C, Menéndez P. Zanetti SR, et al. Mol Ther. 2022 Feb 2;30(2):550-563. doi: 10.1016/j.ymthe.2021.08.033. Epub 2021 Sep 1. Mol Ther. 2022. PMID: 34478871 Free PMC article.
We have generated and functionally validated using cutting-edge assays a 4-1BB-based CD22/CD19 Tan-CAR using in-house-developed novel CD19 and CD22 scFvs. Tan-CAR-expressing T cells showed similar in vitro expansion to CD19-CAR T cells with no increase in tonic sign …
We have generated and functionally validated using cutting-edge assays a 4-1BB-based CD22/CD19 Tan-CAR using in-house-developed novel …
Idiopathic factor V inhibitor in a patient starting haemodialysis.
Sutherland LJ, Tan S, Hanna M. Sutherland LJ, et al. Intern Med J. 2023 Feb;53(2):289-292. doi: 10.1111/imj.15455. Epub 2022 Apr 4. Intern Med J. 2023. PMID: 35373478
The laboratory findings revealed a prolonged activated partial thromboplastin time of 118 s, prothrombin ratio of 4.2, factor V activity of <2% and a factor V inhibitor of 40 Bethesda Units. No clear underlying aetiology was identified. The bleeding settled with …
The laboratory findings revealed a prolonged activated partial thromboplastin time of 118 s, prothrombin ratio of 4.2, factor V activ …
Thrombophilia in pregnancy.
Tan JY. Tan JY. Ann Acad Med Singap. 2002 May;31(3):328-34. Ann Acad Med Singap. 2002. PMID: 12061293 Review.
The major risk factors for thrombosis during pregnancy include thrombophilia, operative delivery, advanced maternal age, obesity and pre-eclampsia; these can be identified in about 70% of women who develop the complication during pregnancy and the puerperium. Due to the higher pr …
The major risk factors for thrombosis during pregnancy include thrombophilia, operative delivery, advanced maternal age, obesity and pre-ecl …
High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts.
Baldera-Aguayo PA, Lee A, Cornish VW. Baldera-Aguayo PA, et al. ACS Synth Biol. 2022 Jul 15;11(7):2429-2444. doi: 10.1021/acssynbio.2c00116. Epub 2022 Jun 14. ACS Synth Biol. 2022. PMID: 35699947 Free PMC article.
Here, we successfully engineered Saccharomyces cerevisiae (baker's yeast) and Saccharomyces boulardii (probiotic yeast) to produce the nonantibiotic fungal anhydrotetracycline, TAN-1612, in synthetic defined medianecessary for clean purificationsthrough heterologously expr …
Here, we successfully engineered Saccharomyces cerevisiae (baker's yeast) and Saccharomyces boulardii (probiotic yeast) to produce the nonan …
5,099 results