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56 results

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Page 1
Small-molecule Ca(V)alpha(1)Ca(V)beta antagonist suppresses neuronal voltage-gated calcium-channel trafficking.
Chen X, Liu D, Zhou D, Si Y, Xu D, Stamatkin CW, Ghozayel MK, Ripsch MS, Obukhov AG, White FA, Meroueh SO. Chen X, et al. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10566-E10575. doi: 10.1073/pnas.1813157115. Epub 2018 Oct 24. Proc Natl Acad Sci U S A. 2018. PMID: 30355767 Free PMC article.
The Ca(V)2.2 channel is composed of a pore-forming alpha(1) subunit (Ca(V)alpha(1)) that is engaged in protein-protein interactions with auxiliary alpha(2)/delta and beta subunits. The high-affinity Ca(V)2.2alpha(1)Ca(V)beta(3) protein-protein interact …
The Ca(V)2.2 channel is composed of a pore-forming alpha(1) subunit (Ca(V)alpha(1)) that is engaged in protein-protein interac …
Kolmogorov or Bolgiano-Obukhov scaling: Universal energy spectra in stably stratified turbulent fluids.
Basu A, Bhattacharjee JK. Basu A, et al. Phys Rev E. 2019 Sep;100(3-1):033117. doi: 10.1103/PhysRevE.100.033117. Phys Rev E. 2019. PMID: 31639948
For very low N or very high Re_{b} or F_{h}, and with l_{v}l_{h}, the typical horizontal length scale, buoyancy forces are irrelevant and hence, unsurprisingly, the kinetic energy spectra show the well-known K41 scaling in the inertial range. ...For intermediate ranges of …
For very low N or very high Re_{b} or F_{h}, and with l_{v}l_{h}, the typical horizontal length scale, buoyancy forces are irrelevant …
Dorzolamide intermediates with potential anti-inflammatory activity.
Atre R, Obukhov AG, Majmudar CY, Nair K, White FA, Sharma R, Siddiqi F, Faisal SM, Varma VP, Hassan MI, Mohammad T, Darwhekar GN, Baig MS. Atre R, et al. Eur J Pharmacol. 2025 Jan 15;987:177160. doi: 10.1016/j.ejphar.2024.177160. Epub 2024 Dec 2. Eur J Pharmacol. 2025. PMID: 39631651
Furthermore, we validated the anti-inflammatory effect of the most efficient DZD intermediate, DRZ V, in a model of mouse sepsis. DRZ V-treated septic mice exhibited improved survival compared to DZD-treated septic mice. ...
Furthermore, we validated the anti-inflammatory effect of the most efficient DZD intermediate, DRZ V, in a model of mouse sepsis. DRZ …
Optical propagation through non-overturning, undulating temperature sheets in the atmosphere.
Muschinski A. Muschinski A. J Opt Soc Am A Opt Image Sci Vis. 2016 Apr 1;33(4):793-800. doi: 10.1364/JOSAA.33.000793. J Opt Soc Am A Opt Image Sci Vis. 2016. PMID: 27140793
Here we present and discuss a model atmosphere characterized by randomly undulating, non-turbulent and non-overturning, quasi-horizontal refractive-index interfaces, or "sheets." We assume n(1)(x)=v[z-h(x,y)], where v(z) is a random function that has a 1D spectrum …
Here we present and discuss a model atmosphere characterized by randomly undulating, non-turbulent and non-overturning, quasi-horizontal ref …
Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels.
Chakraborty S, Berwick ZC, Bartlett PJ, Kumar S, Thomas AP, Sturek M, Tune JD, Obukhov AG. Chakraborty S, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):329-40. doi: 10.1124/jpet.111.183673. Epub 2011 Jul 27. J Pharmacol Exp Ther. 2011. PMID: 21795434 Free PMC article.
BEL completely inhibited not only thapsigargin- but also phenylephrine- and KCl-induced ring contractions, suggesting that Ca(V)1.2 and receptor-operated TRPC channels also may be sensitive to BEL. Therefore, we investigated the effects of BEL on heterologously expressed C …
BEL completely inhibited not only thapsigargin- but also phenylephrine- and KCl-induced ring contractions, suggesting that Ca(V)1.2 a …
New insights into the function and regulation of vitamin D target proteins.
Christakos S, Dhawan P, Peng X, Obukhov AG, Nowycky MC, Benn BS, Zhong Y, Liu Y, Shen Q. Christakos S, et al. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):405-10. doi: 10.1016/j.jsbmb.2006.12.079. Epub 2006 Dec 22. J Steroid Biochem Mol Biol. 2007. PMID: 17257825 Free PMC article.
Co-immunoprecipitation and GST pull down assays indicate that calbindin-D(28k) interacts with the C-terminus of the L-type calcium channel alpha(1c) subunit (Ca(v)1.2). This is the first report of the binding of calbindin to a calcium channel and provides new insight conce …
Co-immunoprecipitation and GST pull down assays indicate that calbindin-D(28k) interacts with the C-terminus of the L-type calcium channel a …
TRPC5 channels undergo changes in gating properties during the activation-deactivation cycle.
Obukhov AG, Nowycky MC. Obukhov AG, et al. J Cell Physiol. 2008 Jul;216(1):162-71. doi: 10.1002/jcp.21388. J Cell Physiol. 2008. PMID: 18247362 Free PMC article.
Since several TRP family members exhibit voltage-dependent properties, we investigated whether the various I-V relationships were due to changes in gating. Using patch-clamp recordings of rat TRPC5 transfected HEK293 cells, we found that TRPC5 currents had distinct biophys …
Since several TRP family members exhibit voltage-dependent properties, we investigated whether the various I-V relationships were due …
Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.
Chen X, Sun W, Gianaris NG, Riley AM, Cummins TR, Fehrenbacher JC, Obukhov AG. Chen X, et al. J Biol Chem. 2014 Apr 4;289(14):9600-10. doi: 10.1074/jbc.M113.536862. Epub 2014 Feb 25. J Biol Chem. 2014. PMID: 24569998 Free PMC article.
Conversely, imperatorin sensitized TRPV1 to acid activation but did not affect the current amplitude and/or the activation-inactivation properties of Na(v)1.7, a channel important for transmission of nociceptive information. Thus, our data indicate that furanocoumarins rep …
Conversely, imperatorin sensitized TRPV1 to acid activation but did not affect the current amplitude and/or the activation-inactivation prop …
TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50).
Obukhov AG, Nowycky MC. Obukhov AG, et al. J Cell Physiol. 2004 Nov;201(2):227-35. doi: 10.1002/jcp.20057. J Cell Physiol. 2004. PMID: 15334657
Each phase had a characteristic non-linear current-voltage (I-V) relationship. Deletion of the VTTRL motif had no detectable effect on the biophysical properties of the channel. ...
Each phase had a characteristic non-linear current-voltage (I-V) relationship. Deletion of the VTTRL motif had no detectable effect o …
56 results