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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1911 1
1951 4
1952 3
1953 5
1954 3
1955 2
1956 1
1957 4
1958 2
1959 3
1960 1
1962 1
1963 23
1964 15
1965 13
1966 2
1967 2
1968 7
1969 5
1971 2
1972 4
1973 5
1974 4
1975 10
1976 12
1977 7
1978 9
1979 10
1980 7
1981 14
1982 7
1983 13
1984 13
1985 11
1986 11
1987 21
1988 9
1989 17
1990 20
1991 18
1992 23
1993 23
1994 28
1995 27
1996 45
1997 52
1998 50
1999 71
2000 88
2001 80
2002 80
2003 61
2004 75
2005 71
2006 71
2007 85
2008 88
2009 73
2010 100
2011 82
2012 93
2013 98
2014 147
2015 137
2016 176
2017 210
2018 196
2019 261
2020 359
2021 432
2022 403
2023 407
2024 190

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4,296 results

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The following term was not found in PubMed: 20Narayanan
Page 1
Management of Myocarditis-Related Cardiomyopathy in Adults.
Tschöpe C, Cooper LT, Torre-Amione G, Van Linthout S. Tschöpe C, et al. Circ Res. 2019 May 24;124(11):1568-1583. doi: 10.1161/CIRCRESAHA.118.313578. Circ Res. 2019. PMID: 31120823 Free article. Review.
V(H) -V(L) interdomain dynamics observed by computer simulations and NMR.
Fernández-Quintero ML, Hoerschinger VJ, Lamp LM, Bujotzek A, Georges G, Liedl KR. Fernández-Quintero ML, et al. Proteins. 2020 Jul;88(7):830-839. doi: 10.1002/prot.25872. Epub 2020 Jan 14. Proteins. 2020. PMID: 31904133 Free PMC article.
ABangle characterizes the V(H) -V(L) orientation by using five angles and a distance and compares it to other known structures. ...Antigen-binding is mediated by the complementarity-determining regions consisting of six loops, each three of the heavy and light chain …
ABangle characterizes the V(H) -V(L) orientation by using five angles and a distance and compares it to other known structures …
NHDL, a recombinant V(L)/V(H) hybrid antibody control for IgG2/4 antibodies.
Lau C, McAdam MB, Bergseth G, Grevys A, Bruun JA, Ludviksen JK, Fure H, Espevik T, Moen A, Andersen JT, Mollnes TE. Lau C, et al. MAbs. 2020 Jan-Dec;12(1):1686319. doi: 10.1080/19420862.2019.1686319. MAbs. 2020. PMID: 31671278 Free PMC article.
Here, we describe the design of a recombinant control antibody (NHDL), which was generated by combining the variable light (V(L)) and heavy (V(H)) chains from two unrelated specificities. NHDL was readily expressed and purified as a stable IgG2/4 antibody, and showe …
Here, we describe the design of a recombinant control antibody (NHDL), which was generated by combining the variable light (V(L …
Antibodies exhibit multiple paratope states influencing V(H)-V(L) domain orientations.
Fernández-Quintero ML, Pomarici ND, Math BA, Kroell KB, Waibl F, Bujotzek A, Georges G, Liedl KR. Fernández-Quintero ML, et al. Commun Biol. 2020 Oct 20;3(1):589. doi: 10.1038/s42003-020-01319-z. Commun Biol. 2020. PMID: 33082531 Free PMC article.
Another important aspect when characterizing different paratope states is the relative V(H)/V(L) orientation and the influence of the distinct CDR loop states on the V(H)/V(L) interface. Conformational rearrangements of the CDR loops do not only have a …
Another important aspect when characterizing different paratope states is the relative V(H)/V(L) orientation and the influence …
Germline-Dependent Antibody Paratope States and Pairing Specific V(H)-V(L) Interface Dynamics.
Fernández-Quintero ML, Kroell KB, Bacher LM, Loeffler JR, Quoika PK, Georges G, Bujotzek A, Kettenberger H, Liedl KR. Fernández-Quintero ML, et al. Front Immunol. 2021 Aug 10;12:675655. doi: 10.3389/fimmu.2021.675655. eCollection 2021. Front Immunol. 2021. PMID: 34447370 Free PMC article.
In this study, we systematically show that different heavy and light chain pairings strongly influence the paratope, interdomain interaction patterns and the relative V(H)-V(L) interface orientations. We observe changes in conformational diversity and substantial po …
In this study, we systematically show that different heavy and light chain pairings strongly influence the paratope, interdomain interaction …
Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V(H)/V(L) Single-Domain Antibodies from In Vitro Display Libraries.
Henry KA, Kim DY, Kandalaft H, Lowden MJ, Yang Q, Schrag JD, Hussack G, MacKenzie CR, Tanha J. Henry KA, et al. Front Immunol. 2017 Dec 12;8:1759. doi: 10.3389/fimmu.2017.01759. eCollection 2017. Front Immunol. 2017. PMID: 29375542 Free PMC article.
Human autonomous V(H)/V(L) single-domain antibodies (sdAbs) are attractive therapeutic molecules, but often suffer from suboptimal stability, solubility and affinity for cognate antigens. Most commonly, human sdAbs have been isolated from in vitro display libraries …
Human autonomous V(H)/V(L) single-domain antibodies (sdAbs) are attractive therapeutic molecules, but often suffer from subopt …
The Versatility of Framework Regions of Chicken V(H) and V(L) to Mutations.
Shin JW, Kim SI, Yoon A, Jin J, Park HB, Kim H, Chung J. Shin JW, et al. Immune Netw. 2018 Jan 31;18(2):e3. doi: 10.4110/in.2018.18.e3. eCollection 2018 Apr. Immune Netw. 2018. PMID: 29732232 Free PMC article.
To identify the interchangeability of V(H) and V(L) framework region (FR) residues, we artificially introduced random mutations at all residue positions in a chicken monoclonal antibody, which has only one functional V(H) and V(lambda) gene. ...
To identify the interchangeability of V(H) and V(L) framework region (FR) residues, we artificially introduced random mutation …
An unusual cysteine V(L)87 affects the antibody fragment conformations without interfering with the disulfide bond formation.
Attallah C, Aguilar MF, Garay AS, Herrera FE, Etcheverrigaray M, Oggero M, Rodrigues DE. Attallah C, et al. Mol Immunol. 2017 Oct;90:143-149. doi: 10.1016/j.molimm.2017.07.008. Epub 2017 Jul 27. Mol Immunol. 2017. PMID: 28755586
This scFv contains 5 Cys residues: V(H)22 and V(H)92 in the variable heavy chain (V(H)) and V(L)23, V(L)87 and V(L)88 in the variable light chain (V(L)). The influence of two unusual contiguous Cys at positions V(L …
This scFv contains 5 Cys residues: V(H)22 and V(H)92 in the variable heavy chain (V(H)) and V(L)23, V(L)87 and …
4,296 results