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Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass.

Goh BC, Singhal V, Herrera AJ, Tomlinson RE, Kim S, Faugere MC, Germain-Lee EL, Clemens TL, Lee SJ, DiGirolamo DJ. Goh BC, et al. Among authors: singhal v. J Biol Chem. 2017 Aug 18;292(33):13809-13822. doi: 10.1074/jbc.M117.782128. Epub 2017 Jun 28. J Biol Chem. 2017. PMID: 28659341 Free PMC article.

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Nrf2 is required for normal postnatal bone acquisition in mice.

Kim JH, Singhal V, Biswal S, Thimmulappa RK, DiGirolamo DJ. Kim JH, et al. Among authors: singhal v. Bone Res. 2014 Nov 11;2:14033. doi: 10.1038/boneres.2014.33. eCollection 2014. Bone Res. 2014. PMID: 26273528 Free PMC article.

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Identification of an Alu element-mediated deletion in the promoter region of GNE in siblings with GNE myopathy.

Garland J, Stephen J, Class B, Gruber A, Ciccone C, Poliak A, Hayes CP, Singhal V, Slota C, Perreault J, Gavrilova R, Shrader JA, Chittiboina P, Joe G, Heiss J, Gahl WA, Huizing M, Carrillo N, Malicdan MCV. Garland J, et al. Among authors: singhal v. Mol Genet Genomic Med. 2017 Jun 14;5(4):410-417. doi: 10.1002/mgg3.300. eCollection 2017 Jul. Mol Genet Genomic Med. 2017. PMID: 28717665 Free PMC article.

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Osteoblast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes.

Singhal V, Goh BC, Bouxsein ML, Faugere MC, DiGirolamo DJ. Singhal V, et al. Bone Res. 2013 Mar 29;1(1):85-97. doi: 10.4248/BR201301006. eCollection 2013 Mar. Bone Res. 2013. PMID: 26273494 Free PMC article.

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Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta.

DiGirolamo DJ, Singhal V, Chang X, Lee SJ, Germain-Lee EL. DiGirolamo DJ, et al. Among authors: singhal v. Bone Res. 2015 Feb 10;3:14042. doi: 10.1038/boneres.2014.42. eCollection 2015. Bone Res. 2015. PMID: 26161291 Free PMC article.

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Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.

Moon DK, Singhal V, Kumar N, Shapiro TA, Posner GH. Moon DK, et al. Among authors: singhal v. Drug Dev Res. 2009 Jan 1;71(1):76-81. doi: 10.1002/ddr.20350. Drug Dev Res. 2009. PMID: 20686674 Free PMC article.

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Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system.

Gao M, Singh A, Macri K, Reynolds C, Singhal V, Biswal S, Spannhake EW. Gao M, et al. Among authors: singhal v. Respir Res. 2011 Jul 13;12(1):92. doi: 10.1186/1465-9921-12-92. Respir Res. 2011. PMID: 21752292 Free PMC article. Clinical Trial.

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Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation.

Kumar S, Singhal V, Roshan R, Sharma A, Rembhotkar GW, Ghosh B. Kumar S, et al. Among authors: singhal v. Eur J Pharmacol. 2007 Dec 1;575(1-3):177-86. doi: 10.1016/j.ejphar.2007.07.056. Epub 2007 Aug 3. Eur J Pharmacol. 2007. PMID: 17764673

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Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells.

Kumar S, Sharma A, Madan B, Singhal V, Ghosh B. Kumar S, et al. Among authors: singhal v. Biochem Pharmacol. 2007 May 15;73(10):1602-12. doi: 10.1016/j.bcp.2007.01.015. Epub 2007 Jan 13. Biochem Pharmacol. 2007. PMID: 17276410

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Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.

Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH. Woodard LE, et al. Among authors: singhal v. Pharmaceuticals (Basel). 2009 Dec 21;2(3):228-235. doi: 10.3390/ph2030228. Pharmaceuticals (Basel). 2009. PMID: 27713236 Free PMC article.

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