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49 results

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Page 1
Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting.
Lee EHJ, Murad JP, Christian L, Gibson J, Yamaguchi Y, Cullen C, Gumber D, Park AK, Young C, Monroy I, Yang J, Stern LA, Adkins LN, Dhapola G, Gittins B, Chang WC, Martinez C, Woo Y, Cristea M, Rodriguez-Rodriguez L, Ishihara J, Lee JK, Forman SJ, Wang LD, Priceman SJ. Lee EHJ, et al. Among authors: chang wc. Nat Commun. 2023 Aug 7;14(1):4737. doi: 10.1038/s41467-023-40115-1. Nat Commun. 2023. PMID: 37550294 Free PMC article.
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells.
Wang Z, McWilliams-Koeppen HP, Reza H, Ostberg JR, Chen W, Wang X, Huynh C, Vyas V, Chang WC, Starr R, Wagner JR, Aguilar B, Yang X, Wu X, Wang J, Chen W, Koelker-Wolfe E, Seet CS, Montel-Hagen A, Crooks GM, Forman SJ, Brown CE. Wang Z, et al. Among authors: chang wc. Cell Stem Cell. 2022 Apr 7;29(4):515-527.e8. doi: 10.1016/j.stem.2022.02.009. Epub 2022 Mar 11. Cell Stem Cell. 2022. PMID: 35278370 Free PMC article.
Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery.
Murad JP, Christian L, Rosa R, Ren Y, Lee EHJ, Lopez LS, Park AK, Yang J, Trac C, Adkins LN, Chang WC, Martinez C, June CH, Forman SJ, Ishihara J, Lee JK, Stern LA, Priceman SJ. Murad JP, et al. Among authors: chang wc. bioRxiv [Preprint]. 2025 May 19:2025.04.04.647304. doi: 10.1101/2025.04.04.647304. bioRxiv. 2025. Update in: Nat Biomed Eng. 2025 Oct 1. doi: 10.1038/s41551-025-01509-2. PMID: 40406466 Free PMC article. Updated. Preprint.
Universal off-the-shelf combination immunotherapy using oncolytic viruses to redirect T cell engagers to target solid tumors.
Park AK, Monroy I, Ren Y, Lu C, Chaurasiya S, Valencia H, Lent-Koop J, Cook C, Kang S, Lopez L, Murad JP, Yamaguchi Y, Urak R, Chang WC, Shah M, Chong LMO, Fong Y, Forman SJ, Wang X, Priceman SJ. Park AK, et al. Among authors: chang wc. J Immunother Cancer. 2025 Aug 11;13(8):e011051. doi: 10.1136/jitc-2024-011051. J Immunother Cancer. 2025. PMID: 40789743 Free PMC article.
Inclusion of 4-1BB Costimulation Enhances Selectivity and Functionality of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells.
Starr R, Aguilar B, Gumber D, Maker M, Huard S, Wang D, Chang WC, Brito A, Chiu V, Ostberg JR, Badie B, Forman SJ, Alizadeh D, Wang LD, Brown CE. Starr R, et al. Among authors: chang wc. Cancer Res Commun. 2023 Jan 17;3(1):66-79. doi: 10.1158/2767-9764.CRC-22-0185. eCollection 2023 Jan. Cancer Res Commun. 2023. PMID: 36968221 Free PMC article.
Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells.
Kennewick KT, Yamaguchi Y, Gibson J, Gerdts EA, Jeang B, Tilakawardane D, Murad JP, Chang WC, Wright SL, Thiel MS, Forman SJ, Stern LA, Priceman SJ. Kennewick KT, et al. Among authors: chang wc. Mol Ther Oncol. 2024 Mar 2;32(2):200789. doi: 10.1016/j.omton.2024.200789. eCollection 2024 Jun 20. Mol Ther Oncol. 2024. PMID: 38939825 Free PMC article.
49 results