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Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.
Look AHEAD Research Group, Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, Crow RS, Curtis JM, Egan CM, Espeland MA, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Harrison B, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitabchi AE, Knowler WC, Lewis CE, Maschak-Carey BJ, Montez MG, Murillo A, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Reboussin D, Regensteiner JG, Rickman AD, Ryan DH, Safford M, Wadden TA, Wagenknecht LE, West DS, Williamson DF, Yanovski SZ. Look AHEAD Research Group, et al. N Engl J Med. 2013 Jul 11;369(2):145-54. doi: 10.1056/NEJMoa1212914. Epub 2013 Jun 24. N Engl J Med. 2013. PMID: 23796131 Free PMC article. Clinical Trial.
RESULTS: The trial was stopped early on the basis of a futility analysis when the median follow-up was 9.6 years. Weight loss was greater in the intervention group than in the control group throughout the study (8.6% vs. 0.7% at 1 year; 6.0% vs. 3.5% at study end). …
RESULTS: The trial was stopped early on the basis of a futility analysis when the median follow-up was 9.6 years. Weight loss was greater in …
Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial.
Look AHEAD Research Group, Wing RR. Look AHEAD Research Group, et al. Arch Intern Med. 2010 Sep 27;170(17):1566-75. doi: 10.1001/archinternmed.2010.334. Arch Intern Med. 2010. PMID: 20876408 Free PMC article. Clinical Trial.
METHODS: The Look AHEAD (Action for Health in Diabetes) trial is a multicenter randomized clinical trial comparing the effects of an intensive lifestyle intervention (ILI) and diabetes support and education (DSE; the control group) on the incidence of major CVD events in 5 …
METHODS: The Look AHEAD (Action for Health in Diabetes) trial is a multicenter randomized clinical trial comparing the effects of an intensi …
A giant thunderstorm on Saturn.
Fischer G, Kurth WS, Gurnett DA, Zarka P, Dyudina UA, Ingersoll AP, Ewald SP, Porco CC, Wesley A, Go C, Delcroix M. Fischer G, et al. Among authors: wesley a. Nature. 2011 Jul 6;475(7354):75-7. doi: 10.1038/nature10205. Nature. 2011. PMID: 21734705
Here we report observations of a giant thunderstorm at planetocentric latitude 35 north that reached a latitudinal extension of 10,000 kilometres-comparable in size to a 'Great White Spot'-about three weeks after it started in early December 2010. ...
Here we report observations of a giant thunderstorm at planetocentric latitude 35 north that reached a latitudinal extension of 10,000 kilom …
The long-term effectiveness of a lifestyle intervention in severely obese individuals.
Unick JL, Beavers D, Bond DS, Clark JM, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wagenknecht LE, Wing RR; Look AHEAD Research Group. Unick JL, et al. Am J Med. 2013 Mar;126(3):236-42, 242.e1-2. doi: 10.1016/j.amjmed.2012.10.010. Am J Med. 2013. PMID: 23410564 Free PMC article. Clinical Trial.
METHODS: There were 5145 individuals with type 2 diabetes (45-76 years, BMI 25 kg/m(2)) randomized to an intensive lifestyle intervention or diabetes support and education. The lifestyle intervention group received a behavioral weight loss program that included group
METHODS: There were 5145 individuals with type 2 diabetes (45-76 years, BMI 25 kg/m(2)) randomized to an intensive lifestyle intervention or …
Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study.
Pownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS, Hill J, Kahn SE, Nathan DM, Schwartz AV, Johnson KC; Look AHEAD Research Group. Pownall HJ, et al. Obesity (Silver Spring). 2015 Mar;23(3):565-72. doi: 10.1002/oby.21005. Obesity (Silver Spring). 2015. PMID: 25707379 Free PMC article. Clinical Trial.
The intervention was designed to achieve and maintain 7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. RESULTS: At 1 year, the intervention group lost fat (5.6 0.2 kg) …
The intervention was designed to achieve and maintain 7% weight loss through increased physical activity and reduced caloric intake. The com …
Intravenous immunoglobulin prophylaxis in neonates on artificial ventilation.
Adhikari M, Wesley AG, Fourie PB. Adhikari M, et al. Among authors: wesley ag. S Afr Med J. 1996 May;86(5):542-5. S Afr Med J. 1996. PMID: 8711553 Clinical Trial.

However, on day 6 the treated group had a mean level of 1,400.3 mg/dl (SD 426.7) versus 710.9 mg/dl (SD 377.4) in the placebo group (P < 0.05). ...Two patients died in the treated and 4 in the placebo group, with 1 infant in each group developing br

However, on day 6 the treated group had a mean level of 1,400.3 mg/dl (SD 426.7) versus 710.9 mg/dl (SD 377.4) in the placebo grou
Four-year weight losses in the Look AHEAD study: factors associated with long-term success.
Wadden TA, Neiberg RH, Wing RR, Clark JM, Delahanty LM, Hill JO, Krakoff J, Otto A, Ryan DH, Vitolins MZ; Look AHEAD Research Group. Wadden TA, et al. Obesity (Silver Spring). 2011 Oct;19(10):1987-98. doi: 10.1038/oby.2011.230. Epub 2011 Jul 21. Obesity (Silver Spring). 2011. PMID: 21779086 Free PMC article. Clinical Trial.
A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group
A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or …
Effect of 5-FU on modulation of disarrangement of immune-associated cytokines in experimental acute pancreatitis.
Chen XL, Ciren SZ, Zhang H, Duan LG, Wesley AJ. Chen XL, et al. Among authors: wesley aj. World J Gastroenterol. 2009 Apr 28;15(16):2032-7. doi: 10.3748/wjg.15.2032. World J Gastroenterol. 2009. PMID: 19399939 Free PMC article.
METHODS: Male Sprague Dawley rats were assigned to 3 Groups: Group A, sham operated rats as controls (n = 7); Group B, acute pancreatitis induced by ductal injection with 5% sodium cholate at a volume of 1.0 mL/kg without any other treatment; Group C, after t …
METHODS: Male Sprague Dawley rats were assigned to 3 Groups: Group A, sham operated rats as controls (n = 7); Group B, acute p …
Lifestyle change and mobility in obese adults with type 2 diabetes.
Rejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW, Zhang Q; Look AHEAD Research Group. Rejeski WJ, et al. N Engl J Med. 2012 Mar 29;366(13):1209-17. doi: 10.1056/NEJMoa1110294. N Engl J Med. 2012. PMID: 22455415 Free PMC article. Clinical Trial.
RESULTS: At year 4, among 2514 adults in the lifestyle-intervention group, 517 (20.6%) had severe disability and 969 (38.5%) had good mobility; the numbers among 2502 participants in the support group were 656 (26.2%) and 798 (31.9%), respectively. The lifestyle-int …
RESULTS: At year 4, among 2514 adults in the lifestyle-intervention group, 517 (20.6%) had severe disability and 969 (38.5%) had good …
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