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Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.

Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y; International Transporter Consortium. Zamek-Gliszczynski MJ, et al. Among authors: wittwer mb. Clin Pharmacol Ther. 2018 Nov;104(5):890-899. doi: 10.1002/cpt.1112. Epub 2018 Aug 8. Clin Pharmacol Ther. 2018. PMID: 30091177 Free PMC article. Review.

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Fundamental aspects of DMPK optimization of targeted protein degraders.

Cantrill C, Chaturvedi P, Rynn C, Petrig Schaffland J, Walter I, Wittwer MB. Cantrill C, et al. Among authors: wittwer mb. Drug Discov Today. 2020 Jun;25(6):969-982. doi: 10.1016/j.drudis.2020.03.012. Epub 2020 Apr 13. Drug Discov Today. 2020. PMID: 32298797 Review.

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Renal transporters in drug development.

Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. Morrissey KM, et al. Among authors: wittwer mb. Annu Rev Pharmacol Toxicol. 2013;53:503-29. doi: 10.1146/annurev-pharmtox-011112-140317. Epub 2012 Nov 8. Annu Rev Pharmacol Toxicol. 2013. PMID: 23140242 Review.

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Chemical development of intracellular protein heterodimerizers.

Erhart D, Zimmermann M, Jacques O, Wittwer MB, Ernst B, Constable E, Zvelebil M, Beaufils F, Wymann MP. Erhart D, et al. Among authors: wittwer mb. Chem Biol. 2013 Apr 18;20(4):549-57. doi: 10.1016/j.chembiol.2013.03.010. Chem Biol. 2013. PMID: 23601644

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Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction.

Umehara K, Cantrill C, Wittwer MB, Di Lenarda E, Klammers F, Ekiciler A, Parrott N, Fowler S, Ullah M. Umehara K, et al. Among authors: wittwer mb. Drug Metab Dispos. 2020 Oct;48(10):849-860. doi: 10.1124/dmd.120.000133. Epub 2020 Aug 1. Drug Metab Dispos. 2020. PMID: 32739889

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The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.

Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. Hibma JE, et al. Among authors: wittwer mb. Clin Pharmacokinet. 2016 Jun;55(6):711-21. doi: 10.1007/s40262-015-0346-3. Clin Pharmacokinet. 2016. PMID: 26597253 Free PMC article. Clinical Trial.

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Targeted protein degraders: a call for collective action to advance safety assessment.

Jones LH, Mitchell CA, Loberg L, Pavkovic M, Rao M, Roberts R, Stamp K, Volak L, Wittwer MB, Pettit S. Jones LH, et al. Among authors: wittwer mb. Nat Rev Drug Discov. 2022 Jun;21(6):401-402. doi: 10.1038/d41573-022-00055-9. Nat Rev Drug Discov. 2022. PMID: 35322806 No abstract available.

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ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.

Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L; International Transporter Consortium. Zamek-Gliszczynski MJ, et al. Among authors: wittwer mb. Clin Pharmacol Ther. 2018 Nov;104(5):781-784. doi: 10.1002/cpt.1082. Epub 2018 May 15. Clin Pharmacol Ther. 2018. PMID: 29761830

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Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.

Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM. Khuri N, et al. Among authors: wittwer mb. J Chem Inf Model. 2017 Jun 26;57(6):1402-1413. doi: 10.1021/acs.jcim.6b00720. Epub 2017 Jun 15. J Chem Inf Model. 2017. PMID: 28562037

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Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold.

He Y, Gobbi LC, Herde AM, Rombach D, Ritter M, Kuhn B, Wittwer MB, Heer D, Hornsperger B, Bell C, O'Hara F, Benz J, Honer M, Keller C, Collin L, Richter H, Schibli R, Grether U, Mu L. He Y, et al. Among authors: wittwer mb. Nucl Med Biol. 2022 May-Jun;108-109:24-32. doi: 10.1016/j.nucmedbio.2022.02.002. Epub 2022 Feb 23. Nucl Med Biol. 2022. PMID: 35248850 Free article.

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