Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 2
2013 4
2014 1
2016 1
2017 1
2018 2
2020 2
2022 5
2023 1
2024 7
2025 7

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

28 results

Results by year

Filters applied: . Clear all
Page 1
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Jiang M, Huizenga MCW, Wirt JL, Paloczi J, Amedi A, van den Berg RJBHN, Benz J, Collin L, Deng H, Di X, Driever WF, Florea BI, Grether U, Janssen APA, Hankemeier T, Heitman LH, Lam TW, Mohr F, Pavlovic A, Ruf I, van den Hurk H, Stevens AF, van der Vliet D, van der Wel T, Wittwer MB, van Boeckel CAA, Pacher P, Hohmann AG, van der Stelt M. Jiang M, et al. Among authors: wittwer mb. Nat Commun. 2023 Dec 5;14(1):8039. doi: 10.1038/s41467-023-43606-3. Nat Commun. 2023. PMID: 38052772 Free PMC article.
Renal transporters in drug development.
Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. Morrissey KM, et al. Among authors: wittwer mb. Annu Rev Pharmacol Toxicol. 2013;53:503-29. doi: 10.1146/annurev-pharmtox-011112-140317. Epub 2012 Nov 8. Annu Rev Pharmacol Toxicol. 2013. PMID: 23140242 Free article. Review.
Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.
Aebi J, Atz K, Ametamey SM, Benz J, Blaising J, Butini S, Campiani G, Carreira EM, Collin L, De Lago E, Gazzi T, Gertsch J, Gobbi L, Guba W, Fernández-Ruiz J, Fingerle J, Haider A, He Y, Heitman LH, Honer M, Hunziker D, Kuhn B, Maccarrone M, Märki HP, Martin RE, Mohr P, Mu L, Nazaré M, Nippa DF, Oddi S, O'Hara F, Pacher P, Romero J, Röver S, Rufer AC, Schibli R, Schneider G, Stepan AF, Sykes DA, Ullmer C, Van der Stelt M, Veprintsev DB, Wittwer MB, Grether U. Aebi J, et al. Among authors: wittwer mb. Chimia (Aarau). 2024 Aug 21;78(7-8):499-512. doi: 10.2533/chimia.2024.499. Chimia (Aarau). 2024. PMID: 39221845 Free article.
Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.
Zamek-Gliszczynski MJ, Sangha V, Shen H, Feng B, Wittwer MB, Varma MVS, Liang X, Sugiyama Y, Zhang L, Bendayan R; International Transporter Consortium. Zamek-Gliszczynski MJ, et al. Among authors: wittwer mb. Clin Pharmacol Ther. 2022 Sep;112(3):485-500. doi: 10.1002/cpt.2644. Epub 2022 Jun 29. Clin Pharmacol Ther. 2022. PMID: 35561119 Review.
Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.
Giroud M, Kuhn B, Steiner S, Westwood P, Mendel M, Mani A, Pinard E, Haap W, Grether U, Caramenti P, Rombach D, Zambaldo C, Ritter M, Schmid P, Gasser C, Aregger N, Séchet N, Topp A, Bilyard M, Malnight-Alvarez A, Plitzko I, Hilbert M, Kalayil S, Burger D, Bonardi C, Saal W, Haider A, Wittwer MB, Brigo A, Benz J, Keaney J. Giroud M, et al. Among authors: wittwer mb. J Med Chem. 2025 Mar 27;68(6):6558-6575. doi: 10.1021/acs.jmedchem.4c03127. Epub 2025 Mar 18. J Med Chem. 2025. PMID: 40100796
Fundamental aspects of DMPK optimization of targeted protein degraders.
Cantrill C, Chaturvedi P, Rynn C, Petrig Schaffland J, Walter I, Wittwer MB. Cantrill C, et al. Among authors: wittwer mb. Drug Discov Today. 2020 Jun;25(6):969-982. doi: 10.1016/j.drudis.2020.03.012. Epub 2020 Apr 13. Drug Discov Today. 2020. PMID: 32298797 Review.
Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y; International Transporter Consortium. Zamek-Gliszczynski MJ, et al. Among authors: wittwer mb. Clin Pharmacol Ther. 2018 Nov;104(5):890-899. doi: 10.1002/cpt.1112. Epub 2018 Aug 8. Clin Pharmacol Ther. 2018. PMID: 30091177 Free PMC article. Review.
Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice.
Gonzalo-Consuegra C, Santos-García I, García-Toscano L, Martín-Baquero R, Rodríguez-Cueto C, Wittwer MB, Dzygiel P, Grether U, de Lago E, Fernández-Ruiz J. Gonzalo-Consuegra C, et al. Among authors: wittwer mb. Biomed Pharmacother. 2024 May;174:116473. doi: 10.1016/j.biopha.2024.116473. Epub 2024 Mar 24. Biomed Pharmacother. 2024. PMID: 38522237 Free article.
Finding a needle in the haystack: ADME and pharmacokinetics/pharmacodynamics characterization and optimization toward orally available bifunctional protein degraders.
Apprato G, Caron G, Deshmukh G, Garcia-Jimenez D, Haid RTU, Pike A, Reichel A, Rynn C, Donglu Z, Wittwer MB. Apprato G, et al. Among authors: wittwer mb. Expert Opin Drug Discov. 2025 Feb 16. doi: 10.1080/17460441.2025.2467195. Online ahead of print. Expert Opin Drug Discov. 2025. PMID: 39956925 Review.
28 results