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Integration of network pharmacology and experimental verification to reveal the active components and molecular mechanism of modified Danzhi Xiaoyao San in the treatment of depression.
Wu M, Yan X, Huang H, Guo X, Bai M, Wang B, Su P, Li Y, Xu E. Wu M, et al. J Ethnopharmacol. 2025 Jan 10;336:118739. doi: 10.1016/j.jep.2024.118739. Epub 2024 Aug 26. J Ethnopharmacol. 2025. PMID: 39197805
ETHNOPHARMACOLOGICAL RELEVANCE: Modified Danzhi Xiaoyao San (MDXS) is an effective clinical prescription for depression in China, which was deprived of Danzhi Xiaoyao San in the Ming Dynasty. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Modified Danzhi Xiaoyao San (MDXS) is an effective clinical prescription for depression in China, whi …
Efficacy and Safety of Xiaoyao Recipe in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis.
Wang D, Li T, Ron J, Mao M, Yang Y, Feng Y, Yan Y. Wang D, et al. Evid Based Complement Alternat Med. 2022 Apr 13;2022:4385783. doi: 10.1155/2022/4385783. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 35463080 Free PMC article. Review.
BACKGROUND: Poststroke depression (PSD) is a common neuropsychiatric disorder that affects the disability, mortality, functional recovery, and quality of daily life of patients. Xiaoyao Recipe (XYR) is often used to treat PSD and has achieved good clinical effects, but it …
BACKGROUND: Poststroke depression (PSD) is a common neuropsychiatric disorder that affects the disability, mortality, functional recovery, a …
Unveiling the Mechanisms and Therapeutic Effects of Xiaoyao Sanjie Decoction in Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Approach.
Qi Y, Xu B, He J, Jiang B, Yan L, Zhou H, Chen S. Qi Y, et al. Drug Des Devel Ther. 2024 Dec 27;18:6263-6281. doi: 10.2147/DDDT.S492047. eCollection 2024. Drug Des Devel Ther. 2024. PMID: 39741917 Free PMC article.
PURPOSE: Triple-negative breast cancer (TNBC) is a disease associated with high incidence and high mortality, which is a major problem threatening women's health. Xiaoyao Sanjie Decoction (XYSJD) exhibits remarkable therapeutic efficacy on TNBC; however, the underlying mec …
PURPOSE: Triple-negative breast cancer (TNBC) is a disease associated with high incidence and high mortality, which is a major problem threa …
Modified Xiaoyao San ameliorates LPS-induced depression-like behavior by inhibiting NLRP3-mediated microglial pyroptosis.
Tian L, Su P, Feng G, Peng S, Liu L, Yan X, Liu X, Li Y, Bai M, Wang B, Xu E. Tian L, et al. Metab Brain Dis. 2025 Nov 22;40(8):324. doi: 10.1007/s11011-025-01751-2. Metab Brain Dis. 2025. PMID: 41273446
Modified Xiaoyao San (MXYS) is a well-established clinical prescription for the treatment of depression in China. ...
Modified Xiaoyao San (MXYS) is a well-established clinical prescription for the treatment of depression in China. ...
Xiaoyao San against depression via glia-mediated neuroinflammation using network pharmacology and experimental validation.
Liu XY, Yan YZ, Jiang AJ, He WY, Fang YY, Li CH, Deng MF, Tan SJ, Zeng P. Liu XY, et al. Sci Rep. 2025 Nov 12;15(1):39708. doi: 10.1038/s41598-025-23296-1. Sci Rep. 2025. PMID: 41225027 Free PMC article.
Xiaoyao San (XYS) has been proven effective in treating depression, but its underlying mechanisms remain to be elucidated. ...
Xiaoyao San (XYS) has been proven effective in treating depression, but its underlying mechanisms remain to be elucidated. ...
[Jiawei Xiaoyao Pills improves depression-like behavior in rats by regulating neurotransmitters, inhibiting inflammation and oxidation and modulating intestinal flora].
Liu Y, Li B, Li Y, Chang L, Wang J, Yang L, Yan Y, Qv K, Liu J, Zhang G, Shen X. Liu Y, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2025 Feb 20;45(2):347-358. doi: 10.12122/j.issn.1673-4254.2025.02.16. Nan Fang Yi Ke Da Xue Xue Bao. 2025. PMID: 40031979 Free PMC article. Chinese.
OBJECTIVES: To explore the bioactive components in Jiawei Xiaoyao Pills (JWXYP) and their mechanisms for alleviating depression-like behaviors. METHODS: The active compounds, key targets, and pathways of JWXYP were identified using TCMSP and TCMIP databases. ...
OBJECTIVES: To explore the bioactive components in Jiawei Xiaoyao Pills (JWXYP) and their mechanisms for alleviating depression-like …
Mechanism Study of Xiaoyao San against Nonalcoholic Steatohepatitis-Related Liver Fibrosis Based on a Combined Strategy of Transcriptome Analysis and Network Pharmacology.
Yan D, Zhang X, Ma C, Huang W, Hao M, Xie L. Yan D, et al. Pharmaceuticals (Basel). 2024 Aug 27;17(9):1128. doi: 10.3390/ph17091128. Pharmaceuticals (Basel). 2024. PMID: 39338294 Free PMC article.
The livers of patients with NASH are more likely to develop fibrosis. Xiaoyao San (XYS) is a classic traditional Chinese medicine (TCM) formula that has been widely used in treating liver diseases. ...
The livers of patients with NASH are more likely to develop fibrosis. Xiaoyao San (XYS) is a classic traditional Chinese medicine (TC …
Ameliorative effect of Xiaoyao-jieyu-san on post-stroke depression and its potential mechanisms.
Wang C, Wu C, Yan Z, Cheng X. Wang C, et al. J Nat Med. 2019 Jan;73(1):76-84. doi: 10.1007/s11418-018-1243-5. Epub 2018 Sep 7. J Nat Med. 2019. PMID: 30194657
This investigation aimed to study the effect of Xiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms. ...
This investigation aimed to study the effect of Xiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms …
Comparative study on effects of Xiaoyao Powder and its modified prescription on plasma metabolomics of rats with chronic immobilization stress.
Luo HG, Chen JX, Zhang Q, Yue GX, Ding J, Zhang HT, Yan XZ, Zhao X, Meng ZZ. Luo HG, et al. Chin J Integr Med. 2013 Aug;19(8):610-5. doi: 10.1007/s11655-012-1092-0. Epub 2012 May 19. Chin J Integr Med. 2013. PMID: 22610956
OBJECTIVE: To determine the changes in the levels of endogenous metabolites in rats with chronic immobilization stress (CIS) taking Xiaoyao Powder (XYP) and its modified prescription version, which lacks the volatile oils extracted from Herba Menthae. ...
OBJECTIVE: To determine the changes in the levels of endogenous metabolites in rats with chronic immobilization stress (CIS) taking Xiaoy …
19 results