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The following term was not found in PubMed: Ya-Chuan
Page 1
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion.
Inouye KE, Prentice KJ, Lee A, Wang ZB, Dominguez-Gonzalez C, Chen MX, Riveros JK, Burak MF, Lee GY, Hotamışlıgil GS. Inouye KE, et al. JCI Insight. 2023 Jul 24;8(14):e164642. doi: 10.1172/jci.insight.164642. JCI Insight. 2023. PMID: 37279064 Free PMC article.
We generated mice with Fabp4 deletion in cells known to express the gene - adipocytes (Adipo-KO), endothelial cells (Endo-KO), myeloid cells (Myeloid-KO), and the whole body (Total-KO) - to examine the contribution of these cell types to basal and stim …
We generated mice with Fabp4 deletion in cells known to express the gene - adipocytes (Adipo-KO), endothelial cells (Endo-KO), …
Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis.
Ma X, Wei X, Niu M, Zhang C, Peng Z, Liu W, Yan J, Su X, Lu S, Cui W, Sesaki H, Zong WX, Ni HM, Ding WX. Ma X, et al. bioRxiv [Preprint]. 2025 Feb 12:2025.02.11.637688. doi: 10.1101/2025.02.11.637688. bioRxiv. 2025. Update in: J Clin Invest. 2025 Dec 16;136(4):e194441. doi: 10.1172/JCI194441. PMID: 39990472 Free PMC article. Updated. Preprint.
METHODS: Dnm1l Flox/Flox ( Dnm1l (F/F) ), Mfn1 (F/F) and Mfn2 (F/F) mice were crossed with albumin-Cre mice to generate liver-specific Dnm1l knockout (L- Dnm1l KO), L- Mfn1 KO, L- Mfn2 KO, L- Mfn1, Mfn2 double KO (DKO), and L- Mfn1, Mfn2, Dnm1l triple …
METHODS: Dnm1l Flox/Flox ( Dnm1l (F/F) ), Mfn1 (F/F) and Mfn2 (F/F) mice were crossed with albumin-Cre mice to generate liver-specific Dnm1l …
Animal models of atherosclerosis.
Kapourchali FR, Surendiran G, Chen L, Uitz E, Bahadori B, Moghadasian MH. Kapourchali FR, et al. World J Clin Cases. 2014 May 16;2(5):126-32. doi: 10.12998/wjcc.v2.i5.126. World J Clin Cases. 2014. PMID: 24868511 Free PMC article. Review.
This mouse model of hypercholesterolemia and atherosclerosis has been also used to investigate the impact of oxidative stress and inflammation on atherogenesis. Low density lipoprotein (LDL)-r-KO mice are a model of human familial hypercholesterolemia. However, unlike apo …
This mouse model of hypercholesterolemia and atherosclerosis has been also used to investigate the impact of oxidative stress and inflammati …
Complosome Regulates Hematopoiesis at the Mitochondria Level.
Konopko A, Łukomska A, Ratajczak J, Kucia M, Ratajczak MZ. Konopko A, et al. Stem Cell Rev Rep. 2025 May;21(4):1001-1012. doi: 10.1007/s12015-025-10856-1. Epub 2025 Mar 7. Stem Cell Rev Rep. 2025. PMID: 40053308 Free PMC article.
Interestingly, the uptake of a glucose fluorescent analog (2-NBDG) increased in C3-KO cells but decreased in C5-KO and C5aR1-KO cells compared to wild-type (WT) mice. Meanwhile, total ATP production in C3-KO cells, unlike that of C5 and C5aR1 mice, was …
Interestingly, the uptake of a glucose fluorescent analog (2-NBDG) increased in C3-KO cells but decreased in C5-KO and C5aR1- …
A reexamination of krill oil bioavailability studies.
Salem N Jr, Kuratko CN. Salem N Jr, et al. Lipids Health Dis. 2014 Aug 26;13:137. doi: 10.1186/1476-511X-13-137. Lipids Health Dis. 2014. PMID: 25156381 Free PMC article.
It has proven difficult to compare the bioavailability of krill oil (KO) vs. fish oil (FO) due to several of the characteristics of KO. These include the lower concentration of the active ingredients, eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DH …
It has proven difficult to compare the bioavailability of krill oil (KO) vs. fish oil (FO) due to several of the characteristics of …
Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia in Chrebp Knockout Mice.
Ushiroda C, Ito M, Yamamoto-Wada R, Deguchi K, Hidaka S, Imaizumi T, Seino Y, Suzuki A, Yabe D, Iizuka K. Ushiroda C, et al. Int J Mol Sci. 2025 Dec 2;26(23):11672. doi: 10.3390/ijms262311672. Int J Mol Sci. 2025. PMID: 41373820 Free PMC article.

WT-STZ; 2.58 [-1.23, 6.39] (p = 0.21); KO-vehicle vs. KO-STZ: 8.03 [5.23, 10.82]; GA muscle: WT vehicle vs. WT STZ: 0.084 [0.047, 0.12], p < 0.0001; KO vehicle vs. KO STZ: 0.084, [0.047, 0.12], p < 0.0001). The decrease in grip strength caused by

…
WT-STZ; 2.58 [-1.23, 6.39] (p = 0.21); KO-vehicle vs. KO-STZ: 8.03 [5.23, 10.82]; GA muscle: WT vehicle vs. WT STZ: 0.084 [0.0 …
A comparison of adiponectin-deficient mice reveals the fundamental role of intracellular adiponectin.
Onodera T, Kim DS, Wang MY, Virostek M, Chen S, Kipp ZA, Bates EA, Li Y, Crewe C, Li C, Sun XN, Zhang Q, Shao M, Shin J, Kusminski CM, Gordillo R, Gupta RK, Hinds TD, Shimomura I, Scherer PE. Onodera T, et al. bioRxiv [Preprint]. 2025 Jul 14:2025.07.12.664095. doi: 10.1101/2025.07.12.664095. bioRxiv. 2025. PMID: 40791378 Free PMC article. Preprint.
A complete adiponectin KO model, such as the Dallas KO mouse, exhibits a lower body weight, the highest adipocyte mitochondrial function and displays a susceptibility to DNA damage-mediated lung fibrosis. The reconstitution of globular adiponectin into the Dallas …
A complete adiponectin KO model, such as the Dallas KO mouse, exhibits a lower body weight, the highest adipocyte mitochondria …
Galectin-3 protects auditory function in female mice.
Zhang C, Adler HJ, Manohar S, Salvi R, Sun W, Ye M, Hu BH. Zhang C, et al. Hear Res. 2022 Oct;424:108602. doi: 10.1016/j.heares.2022.108602. Epub 2022 Sep 5. Hear Res. 2022. PMID: 36103788
Noticeably, the threshold deterioration in female KO mice is significantly greater than in the male KO and WT mice. The ABR threshold elevation manifests over a broad frequency range in female KO mice, whereas the threshold elevations are confined to high fre …
Noticeably, the threshold deterioration in female KO mice is significantly greater than in the male KO and WT mice. The ABR th …
Overexpressed MicroRNA-455-3p enhances cognitive function in late-onset Alzheimer's disease.
Islam MA, Kshirsagar S, Alvir RV, Pradeepkiran JA, Bandaru M, Mukherjee U, Reddy PH. Islam MA, et al. Brain Res. 2025 Oct 15;1865:149853. doi: 10.1016/j.brainres.2025.149853. Epub 2025 Jul 21. Brain Res. 2025. PMID: 40701524
In contrast, miR-455-3p KO and KO X hAbKI mice exhibited impaired cognitive functionand reduced motor performance. In addition, miR-455-3p KO and KO X hAbKI mice showed increased anxiety-like behavior in the light-dark (LD) test. ...
In contrast, miR-455-3p KO and KO X hAbKI mice exhibited impaired cognitive functionand reduced motor performance. In addition …
STATISTICAL COMPARISONS OF CHROMOSOMAL SHAPE POPULATIONS.
Soto CJ, Zhao PA, Klein KN, Gilbert DM, Srivastava A. Soto CJ, et al. Proc IEEE Int Symp Biomed Imaging. 2021 Apr;2021:788-791. doi: 10.1109/isbi48211.2021.9433812. Epub 2021 May 25. Proc IEEE Int Symp Biomed Imaging. 2021. PMID: 35165532 Free PMC article.
This paper develops statistical tools for testing differences in shapes of chromosomes resulting from certain gene knockouts (KO), specifically RIF1 gene KO (RKO) and the cohesin subunit RAD21 gene KO (CKO). It utilizes a two-sample test for comparing shapes …
This paper develops statistical tools for testing differences in shapes of chromosomes resulting from certain gene knockouts (KO), sp …
89,114 results
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