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Topically applied virus-like particles containing HIV-1 Pr55gag protein reach skin antigen-presenting cells after mild skin barrier disruption.
Rancan F, Afraz Z, Hadam S, Weiß L, Perrin H, Kliche A, Schrade P, Bachmann S, Schäfer-Korting M, Blume-Peytavi U, Wagner R, Combadière B, Vogt A. Rancan F, et al. Among authors: afraz z. J Control Release. 2017 Dec 28;268:296-304. doi: 10.1016/j.jconrel.2017.10.033. Epub 2017 Nov 5. J Control Release. 2017. PMID: 29080666
Hair follicle targeting, penetration enhancement and Langerhans cell activation make cyanoacrylate skin surface stripping a promising delivery technique for transcutaneous immunization with large molecules and particle-based vaccines.
Vogt A, Hadam S, Deckert I, Schmidt J, Stroux A, Afraz Z, Rancan F, Lademann J, Combadiere B, Blume-Peytavi U. Vogt A, et al. Among authors: afraz z. Exp Dermatol. 2015 Jan;24(1):73-5. doi: 10.1111/exd.12589. Epub 2014 Dec 8. Exp Dermatol. 2015. PMID: 25382068