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Efficacy and tolerability of Guizhi-Shaoyao-Zhimu decoction in gout patients: a systematic review and Meta-analysis.
Zhang Q, Li R, Liu J, Peng W, Fan W, Gao Y, Jin W, Wu C. Zhang Q, et al. Pharm Biol. 2020 Dec;58(1):1023-1034. doi: 10.1080/13880209.2020.1823426. Pharm Biol. 2020. PMID: 33205687 Free PMC article.
CONTEXT: Guizhi-Shaoyao-Zhimu decoction (GSZD), a famous ancient oriental Chinese prescription, has been widely used for thousands of years to treat 'arthromyodynia'. ...
CONTEXT: Guizhi-Shaoyao-Zhimu decoction (GSZD), a famous ancient oriental Chinese prescription, has been widely used for thousands of …
Clinical efficacy evaluation and potential mechanism prediction on Guizhi-Shaoyao-Zhimu decoction in the treatment of gouty arthritis based on meta-analysis, network pharmacology analysis, and molecular docking.
Qu P, Wang H, Wang W, Hu Q, Du S, Peng Z, Tang X. Qu P, et al. Medicine (Baltimore). 2023 Nov 24;102(47):e35973. doi: 10.1097/MD.0000000000035973. Medicine (Baltimore). 2023. PMID: 38013344 Free PMC article.
BACKGROUND: Guizhi-Shaoyao-Zhimu decoction (GSZD) is a Chinese herb formula. Previous studies have reported that the clinical symptoms and laboratory indicators of gouty arthritis patients could be improved by GSZD. ...
BACKGROUND: Guizhi-Shaoyao-Zhimu decoction (GSZD) is a Chinese herb formula. Previous studies have reported that the clinical symptom …
Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts.
Zhang Q, Peng W, Wei S, Wei D, Li R, Liu J, Peng L, Yang S, Gao Y, Wu C, Pu X. Zhang Q, et al. Biomed Pharmacother. 2019 Oct;118:109367. doi: 10.1016/j.biopha.2019.109367. Epub 2019 Aug 21. Biomed Pharmacother. 2019. PMID: 31545276 Free article.
BACKGROUND: Rheumatoid arthritis (RA) is a known intractable chronic inflammatory disease of synovial joints characterized by hyperplasia and consecutive inflammation with a high prevalence.Guizhi-Shaoyao-Zhimu (GSZD) is the first choice for clinical treatment of RA in Chi …
BACKGROUND: Rheumatoid arthritis (RA) is a known intractable chronic inflammatory disease of synovial joints characterized by hyperplasia an …
Inducing Apoptosis and Suppressing Inflammatory Reactions in Synovial Fibroblasts are Two Important Ways for Guizhi-Shaoyao-Zhimu Decoction Against Rheumatoid Arthritis.
Zhang Q, Duan HX, Li RL, Sun JY, Liu J, Peng W, Wu CJ, Gao YX. Zhang Q, et al. J Inflamm Res. 2021 Jan 26;14:217-236. doi: 10.2147/JIR.S287242. eCollection 2021. J Inflamm Res. 2021. PMID: 33542641 Free PMC article.
BACKGROUND AND OBJECTIVES: Guizhi-Shaoyao-Zhimu decoction (GSZD) is often applied to control rheumatoid arthritis (RA), gout, osteoarthritis, etc. ...
BACKGROUND AND OBJECTIVES: Guizhi-Shaoyao-Zhimu decoction (GSZD) is often applied to control rheumatoid arthritis (RA), gout, osteoar …
Identification of the Active Constituents and Significant Pathways of Guizhi-Shaoyao-Zhimu Decoction for the Treatment of Diabetes Mellitus Based on Molecular Docking and Network Pharmacology.
Zhang Q, Li R, Peng W, Zhang M, Liu J, Wei S, Wang J, Wu C, Gao Y, Pu X. Zhang Q, et al. Comb Chem High Throughput Screen. 2019;22(9):584-598. doi: 10.2174/1386207322666191022101613. Comb Chem High Throughput Screen. 2019. PMID: 31642770
AIM AND OBJECTIVE: This study was designed to explore the active compounds and significant pathways of Guizhi-Shaoyao-Zhimu decoction (GSZD) for treating diabetes mellitus using molecular docking combined with network pharmacology. ...
AIM AND OBJECTIVE: This study was designed to explore the active compounds and significant pathways of Guizhi-Shaoyao-Zhimu decoction …
Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-kappaB signalling to suppress osteoclastogenesis.
Wei SJ, Zhang Q, Xiang YJ, Peng LY, Peng W, Ren Q, Gao YX. Wei SJ, et al. Pharm Biol. 2021 Dec;59(1):262-274. doi: 10.1080/13880209.2021.1876100. Pharm Biol. 2021. PMID: 33626293 Free PMC article.

CONTEXT: Guizhi-Shaoyao-Zhimu decoction (GSZD) is commonly used to treat rheumatoid arthritis (RA), but its mechanism is unclear. ...GSZD upregulated IkappaB (p < 0.01) and p65 (p < 0.01) in the cytoplasm and downregulated p65 (p < 0.01) in the cell nucleus. CONCL

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CONTEXT: Guizhi-Shaoyao-Zhimu decoction (GSZD) is commonly used to treat rheumatoid arthritis (RA), but its mechanism is unclear. ... …
[Spectrum-effect relationship between HPLC fingerprint and free radicals scavenging in Guizhi Shaoyao Zhimu Decoction].
Qin Y, Zeng HR, Wang L, Ran Q, Peng W, Gao YX, Huang QW, Tan J. Qin Y, et al. Zhongguo Zhong Yao Za Zhi. 2019 Jul;44(14):3042-3048. doi: 10.19540/j.cnki.cjcmm.20190410.305. Zhongguo Zhong Yao Za Zhi. 2019. PMID: 31602851 Chinese.
To establish the spectrum-effect relationship between HPLC fingerprint and free radicals activity scavenging in Guizhi Shaoyao Zhimu Decoction( GSZD),and provide a basis for the quality evaluation and modernization of classical prescriptions. ...
To establish the spectrum-effect relationship between HPLC fingerprint and free radicals activity scavenging in Guizhi Shaoyao Zhimu …