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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1962 1
1963 1
1964 1
1966 2
1967 4
1968 3
1969 11
1970 8
1971 11
1972 5
1973 9
1974 11
1975 9
1976 6
1977 5
1978 6
1979 8
1980 15
1981 7
1982 8
1983 9
1984 10
1985 7
1986 12
1987 17
1988 19
1989 22
1990 39
1991 41
1992 54
1993 47
1994 56
1995 53
1996 60
1997 66
1998 75
1999 88
2000 85
2001 108
2002 85
2003 90
2004 117
2005 109
2006 130
2007 133
2008 131
2009 154
2010 148
2011 165
2012 184
2013 169
2014 156
2015 205
2016 178
2017 195
2018 182
2019 209
2020 175
2021 144
2022 60
2023 50
2024 48
2025 7

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3,885 results

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Page 1
Spatially resolved single-cell translatomics at molecular resolution.
Zeng H, Huang J, Ren J, Wang CK, Tang Z, Zhou H, Zhou Y, Shi H, Aditham A, Sui X, Chen H, Lo JA, Wang X. Zeng H, et al. Science. 2023 Jun 30;380(6652):eadd3067. doi: 10.1126/science.add3067. Epub 2023 Jun 30. Science. 2023. PMID: 37384709 Free PMC article.
We mapped 5413 genes in mouse brain tissues, yielding spatially resolved single-cell translatomic profiles for 119,173 cells and revealing cell type-specific and brain region-specific translational regulation, including translation remodeling during oligodendrocyte …
We mapped 5413 genes in mouse brain tissues, yielding spatially resolved single-cell translatomic profiles for 119,173 cells and reve …
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.
Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D. Naldini L, et al. Science. 1996 Apr 12;272(5259):263-7. doi: 10.1126/science.272.5259.263. Science. 1996. PMID: 8602510
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLa cells and rat fibroblasts blocked in the cell cycle, as well as into human p …
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based …
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies.
Tillberg PW, Chen F, Piatkevich KD, Zhao Y, Yu CC, English BP, Gao L, Martorell A, Suk HJ, Yoshida F, DeGennaro EM, Roossien DH, Gong G, Seneviratne U, Tannenbaum SR, Desimone R, Cai D, Boyden ES. Tillberg PW, et al. Nat Biotechnol. 2016 Sep;34(9):987-92. doi: 10.1038/nbt.3625. Epub 2016 Jul 4. Nat Biotechnol. 2016. PMID: 27376584 Free PMC article.
Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson's disease treatment.
Kojima R, Bojar D, Rizzi G, Hamri GC, El-Baba MD, Saxena P, Ausländer S, Tan KR, Fussenegger M. Kojima R, et al. Nat Commun. 2018 Apr 3;9(1):1305. doi: 10.1038/s41467-018-03733-8. Nat Commun. 2018. PMID: 29610454 Free PMC article.
Further, engineered producer cells implanted in living mice could consistently deliver cargo mRNA to the brain. Therapeutic catalase mRNA delivery by designer exosomes attenuated neurotoxicity and neuroinflammation in in vitro and in vivo models of Parkinson's disease, ind …
Further, engineered producer cells implanted in living mice could consistently deliver cargo mRNA to the brain. Therapeutic catalase …
SARS-CoV-2 ORF3a expression in brain disrupts the autophagy-lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis.
Zhu H, Byrnes C, Lee YT, Tuymetova G, Duffy HBD, Bakir JY, Pettit SN, Angina J, Springer DA, Allende ML, Kono M, Proia RL. Zhu H, et al. FASEB J. 2023 May;37(5):e22919. doi: 10.1096/fj.202300149R. FASEB J. 2023. PMID: 37071464
Furthermore, ORF3a expression blocked autophagy progression in the brain and caused the neuronal accumulation of alpha-synuclein and glycosphingolipids, all of which are linked to neurodegenerative disease. Studies with ORF3-expressing HeLa cells confirmed that ORF3 …
Furthermore, ORF3a expression blocked autophagy progression in the brain and caused the neuronal accumulation of alpha-synuclein and …
Multimodal nonlinear-optical imaging of nucleoli.
Pochechuev MS, Lanin AA, Kelmanson IV, Chebotarev AS, Fetisova ES, Bilan DS, Shevchenko EK, Ivanov AA, Fedotov AB, Belousov VV, Zheltikov AM. Pochechuev MS, et al. Opt Lett. 2021 Aug 1;46(15):3608-3611. doi: 10.1364/OL.416300. Opt Lett. 2021. PMID: 34329236
THG is shown to provide a versatile readout for unstained nucleolus imaging in a vast class of biological systems as different as neurons in brain slices and cultured HeLa cells....
THG is shown to provide a versatile readout for unstained nucleolus imaging in a vast class of biological systems as different as neurons in …
Expression of the rat brain creatine transporter in situ and in transfected HeLa cells.
Saltarelli MD, Bauman AL, Moore KR, Bradley CC, Blakely RD. Saltarelli MD, et al. Dev Neurosci. 1996;18(5-6):524-34. doi: 10.1159/000111450. Dev Neurosci. 1996. PMID: 8940628
Two rCREAT mRNAs are expressed in the rat brain, retina, kidney and heart. Whole-brain rCREAT mRNAs demonstrate a marked postnatal rise to steady-state adult levels. In situ hybridization studies indicate a widespread, differential rCREAT mRNA expression in adult ra …
Two rCREAT mRNAs are expressed in the rat brain, retina, kidney and heart. Whole-brain rCREAT mRNAs demonstrate a marked postn …
PURA and GLUT1: Sweet partners for brain health.
Colombo RB, Maxit C, Martinelli D, Anderson M, Masone D, Mayorga L. Colombo RB, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Aug;1870(6):167261. doi: 10.1016/j.bbadis.2024.167261. Epub 2024 May 20. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38777099
In this current study, we expand the patient cohort with PURA mutations exhibiting hypoglycorrhachia and aim to unravel the molecular basis of this phenomenon. We established an in vitro model in HeLa cells to modulate PURA expression and investigated GLUT1 function and ex …
In this current study, we expand the patient cohort with PURA mutations exhibiting hypoglycorrhachia and aim to unravel the molecular basis …
Fam96b recruits brain-type creatine kinase to fuel mitotic spindle formation.
Zhang XH, Chen XJ, Yan YB. Zhang XH, et al. Biochim Biophys Acta Mol Cell Res. 2023 Feb;1870(2):119410. doi: 10.1016/j.bbamcr.2022.119410. Epub 2022 Dec 8. Biochim Biophys Acta Mol Cell Res. 2023. PMID: 36503010 Free article.
In this study, Fam96b/MIP18, a component of the MMXD complex with a function in Fe/S cluster supply, was identified as a brain-type CK (CKB)-binding protein. The binding of Fam96b with CKB was independent of the presence of CKB substrates and did not interfere with CKB act …
In this study, Fam96b/MIP18, a component of the MMXD complex with a function in Fe/S cluster supply, was identified as a brain-type C …
3,885 results