COGNITION-GUIDE - Genomics-Guided Targeted Post-Neoadjuvant Therapy in Patients with Early Breast Cancer: Study Design of a Multicenter, Open-Label, Umbrella Phase II Study.
Pixberg C, Maurer C, Smetanay K, Straßl L, Hlevnjak M, Zapatka M, Wagner CV, Yazdanparast H, Kurzawa J, Erben V, Feng F, Hong C, Hübschmann D, Buschhorn L, Suppelna JP, Michel L, Heublein S, Fremd C, Zivanovic O, Sinn P, Stenzinger A, Haidinger R, Schumacher-Wulf E, Ditsch N, Loibl S, Fröhling S, Link T, Wimberger P, Blohmer JU, Huebner H, Fasching PA, Janni W, Schlenk RF, Thewes V, Lichter P, Schneeweiss A.
Pixberg C, et al.
Geburtshilfe Frauenheilkd. 2025 Apr 10;85(6):611-619. doi: 10.1055/a-2557-1876. eCollection 2025 Jun.
Geburtshilfe Frauenheilkd. 2025.
PMID: 40510401
Free PMC article.
Patients can be allocated toimmune checkpoint inhibition (PD-L1-antibody),PI3K inhibition,AKT inhibition,PARP inhibition,anti-Trop-2 antibody-drug-conjugate,HER2 inhibition or, in case of missing biomarkers, to observation for 12 months.The primary endpoint is invasive dis …
Patients can be allocated toimmune checkpoint inhibition (PD-L1-antibody),PI3K inhibition,AKT inhibition,PARP inhibition,anti-Trop-2 …