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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1980 2
1981 2
1983 4
1984 3
1985 10
1986 6
1987 1
1988 1
1989 4
1990 1
1991 2
1992 6
1993 6
1994 7
1995 6
1996 5
1997 6
1998 9
1999 11
2000 9
2001 13
2002 18
2003 20
2004 23
2005 23
2006 23
2007 39
2008 33
2009 30
2010 36
2011 31
2012 27
2013 48
2014 30
2015 26
2016 47
2017 48
2018 54
2019 54
2020 57
2021 43
2022 47
2023 52
2024 17

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848 results

Results by year

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Page 1
Expert consensus on the systemic treatment of atopic dermatitis in special populations.
Adam DN, Gooderham MJ, Beecker JR, Hong CH, Jack CS, Jain V, Lansang P, Lynde CW, Papp KA, Prajapati VH, Turchin I, Yeung J. Adam DN, et al. J Eur Acad Dermatol Venereol. 2023 Jun;37(6):1135-1148. doi: 10.1111/jdv.18922. Epub 2023 Feb 8. J Eur Acad Dermatol Venereol. 2023. PMID: 36695072 Review.
We performed a literature search and examined each clinical scenario with respect to three major categories of available systemic agents: traditional systemics (azathioprine, cyclosporine A, methotrexate, and mycophenolate mofetil), Janus kinase inhibitors (abrocitinib, ba …
We performed a literature search and examined each clinical scenario with respect to three major categories of available systemic age …
PAPP-A and the IGF system.
Monget P, Oxvig C. Monget P, et al. Ann Endocrinol (Paris). 2016 Jun;77(2):90-6. doi: 10.1016/j.ando.2016.04.015. Epub 2016 May 5. Ann Endocrinol (Paris). 2016. PMID: 27155776 Review.
Finally, PAPP-A may serve as a therapeutic target to indirectly inhibit IGF signalling in tissues where this is driven by increased PAPP-A activity. By taking advantage of the intricate interaction between PAPP-A and IGFBP-4, highly specific and selective inh …
Finally, PAPP-A may serve as a therapeutic target to indirectly inhibit IGF signalling in tissues where this is driven by increased …
Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis.
Papp KA, Blauvelt A, Bukhalo M, Gooderham M, Krueger JG, Lacour JP, Menter A, Philipp S, Sofen H, Tyring S, Berner BR, Visvanathan S, Pamulapati C, Bennett N, Flack M, Scholl P, Padula SJ. Papp KA, et al. N Engl J Med. 2017 Apr 20;376(16):1551-1560. doi: 10.1056/NEJMoa1607017. N Engl J Med. 2017. PMID: 28423301 Free article. Clinical Trial.
In the 18-mg and 90-mg risankizumab groups and the ustekinumab group, 5 patients (12%), 6 patients (15%), and 3 patients (8%), respectively, had serious adverse events, including two basal-cell carcinomas and one major cardiovascular adverse event; there were no serious ad …
In the 18-mg and 90-mg risankizumab groups and the ustekinumab group, 5 patients (12%), 6 patients (15%), and 3 patients (8%), respectively, …
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J. Zhong Q, et al. Cell Discov. 2022 Dec 22;8(1):137. doi: 10.1038/s41421-022-00502-2. Cell Discov. 2022. PMID: 36550107 Free PMC article.
While the vast majority of the circulatory PAPP-A in pregnancy is proteolytically inactive due to covalent inhibition by proform of eosinophil major basic protein (proMBP), the activity of PAPP-A can also be covalently inhibited by another less charact …
While the vast majority of the circulatory PAPP-A in pregnancy is proteolytically inactive due to covalent inhibition by profo …
The Multi-Faced Role of PAPP-A in Post-Partum Breast Cancer: IGF-Signaling is Only the Beginning.
Jenkins EC, Brown SO, Germain D. Jenkins EC, et al. J Mammary Gland Biol Neoplasia. 2020 Sep;25(3):181-189. doi: 10.1007/s10911-020-09456-1. Epub 2020 Sep 8. J Mammary Gland Biol Neoplasia. 2020. PMID: 32901383 Review.
In the current review, we focus on Pregnancy-Associated Plasma Protein A (PAPP-A), a protease involved in the degradation of IGFBP-5. PAPP-A is overexpressed in the majority of breast cancers but its role in cancer has only begun to be explored. ...Finally, c …
In the current review, we focus on Pregnancy-Associated Plasma Protein A (PAPP-A), a protease involved in the degradation of IGFBP-5. …
Challenges of Pituitary Apoplexy in Pregnancy.
Gheorghe AM, Trandafir AI, Stanciu M, Popa FL, Nistor C, Carsote M. Gheorghe AM, et al. J Clin Med. 2023 May 11;12(10):3416. doi: 10.3390/jcm12103416. J Clin Med. 2023. PMID: 37240522 Free PMC article. Review.
Our purpose is to provide new insights concerning the challenges of pituitary apoplexy in pregnancy (PAP) and the postpartum period (PAPP). This is a narrative review of the English literature using a PubMed search. ...Most PA-associated tumors were prolactinomas (N = 26/4 …
Our purpose is to provide new insights concerning the challenges of pituitary apoplexy in pregnancy (PAP) and the postpartum period (PAPP …
Perspectives for therapy of treatment-resistant depression.
Papp M, Cubala WJ, Swiecicki L, Newman-Tancredi A, Willner P. Papp M, et al. Br J Pharmacol. 2022 Sep;179(17):4181-4200. doi: 10.1111/bph.15596. Epub 2021 Jul 29. Br J Pharmacol. 2022. PMID: 34128229 Free article. Review.
A high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment-resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past decade have novel treatments, including deep brain stimulation …
A high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment-resistant depression (TRD) is a major …
The Synucleinopathies: Twenty Years On.
Goedert M, Jakes R, Spillantini MG. Goedert M, et al. J Parkinsons Dis. 2017;7(s1):S51-S69. doi: 10.3233/JPD-179005. J Parkinsons Dis. 2017. PMID: 28282814 Free PMC article. Review.
In 1998, multiple system atrophy joined Parkinson's disease and dementia with Lewy bodies as the third major synucleinopathy. Here we review our work, which led to the identification of alpha-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies, as well as …
In 1998, multiple system atrophy joined Parkinson's disease and dementia with Lewy bodies as the third major synucleinopathy. Here we …
Covalent interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A.
Sivanandam AS, Mohan S, Kapur S, Kita H, Lau KH, Bagi G, Baylink DJ, Qin X. Sivanandam AS, et al. Arch Biochem Biophys. 2004 Mar 15;423(2):343-50. doi: 10.1016/j.abb.2004.01.005. Arch Biochem Biophys. 2004. PMID: 15001398
This study was undertaken to determine the mechanism by which proform of eosinophil major basic protein (proMBP) inhibits the IGFBP-4 proteolytic activity of pregnancy-associated plasma protein (PAPP)-A. Co-overexpression of PAPP-A with proMBP in 293T cells, …
This study was undertaken to determine the mechanism by which proform of eosinophil major basic protein (proMBP) inhibits the IGFBP-4 …
Pregnancy-associated plasma protein A (PAPP-A): theoretical and clinical aspects.
Fialova L, Malbohan IM. Fialova L, et al. Bratisl Lek Listy. 2002;103(6):194-205. Bratisl Lek Listy. 2002. PMID: 12448565 Review.
Pregnancy-associated plasma protein A (PAPP-A) is an important pregnancy protein. PAPP-A exists in pregnancy serum as a heterotetrameric 2:2 complex with the proform of eosinophil major basic protein (proMBP), forming an approximately 500 kDa and called PA …
Pregnancy-associated plasma protein A (PAPP-A) is an important pregnancy protein. PAPP-A exists in pregnancy serum as a hetero …
848 results