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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1950 1
1951 1
1953 1
1954 1
1955 4
1959 1
1961 5
1962 3
1963 5
1964 23
1965 33
1966 67
1967 59
1968 39
1969 11
1970 18
1971 3
1972 7
1973 3
1974 13
1975 6
1976 12
1977 15
1978 18
1979 21
1980 23
1981 19
1982 12
1983 23
1984 22
1985 22
1986 30
1987 64
1988 76
1989 114
1990 117
1991 100
1992 137
1993 128
1994 129
1995 161
1996 141
1997 152
1998 185
1999 173
2000 225
2001 319
2002 355
2003 382
2004 427
2005 497
2006 517
2007 536
2008 639
2009 644
2010 719
2011 775
2012 810
2013 912
2014 1096
2015 1214
2016 1372
2017 1435
2018 1566
2019 1650
2020 1798
2021 2149
2022 1880
2023 1639
2024 1930
2025 1954
2026 570

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26,641 results

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Page 1
The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK. Pendleton KE, et al. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003. Cell. 2017. PMID: 28525753 Free PMC article.
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. We demonstrate that the N(6)-adenosine methyltransferase METTL16 regulates expression of human MAT2A, which encodes the SAM syn …
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. W …
One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages.
Yu W, Wang Z, Zhang K, Chi Z, Xu T, Jiang D, Chen S, Li W, Yang X, Zhang X, Wu Y, Wang D. Yu W, et al. Mol Cell. 2019 Sep 19;75(6):1147-1160.e5. doi: 10.1016/j.molcel.2019.06.039. Epub 2019 Aug 13. Mol Cell. 2019. PMID: 31420217 Free article.
Glucose-derived ribose and one-carbon units fed by both glucose and serine metabolism are synergistically integrated into the methionine cycle through de novo ATP synthesis and fuel the generation of S-adenosylmethionine (SAM) during LPS-induced inflammation. Impairment of …
Glucose-derived ribose and one-carbon units fed by both glucose and serine metabolism are synergistically integrated into the methionine cyc …
METTL14 integrates tumor-derived SAM to drive parabrachial epigenetic rewiring in pancreatic cancer.
Yang X, Wang X, Lu W, Ye Q, Li Y, Ma X, Ye Y, Guo X, Chen G, Xin W, Xu T, Zeng W, Xie J. Yang X, et al. Neuron. 2026 Jan 21;114(2):250-267.e8. doi: 10.1016/j.neuron.2025.10.002. Epub 2025 Nov 4. Neuron. 2026. PMID: 41192426
ADM suppression and chemogenetic or optogenetic silencing of LPBN(Glu) PVT(Glu)/LH(Glu) circuits significantly mitigated comorbidity. Moreover, elevated circulating SAM in PDAC patients and mice amplifies this pathway. A methionine-restricted diet (MRD) reduced SAM …
ADM suppression and chemogenetic or optogenetic silencing of LPBN(Glu) PVT(Glu)/LH(Glu) circuits significantly mitigated comorbidity. More …
Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota.
Benjdia A, Berteau O. Benjdia A, et al. Biochem Soc Trans. 2016 Feb;44(1):109-15. doi: 10.1042/BST20150191. Biochem Soc Trans. 2016. PMID: 26862195 Review.
Humans live in a permanent association with bacterial populations collectively called the microbiota. ...Despite tremendous progresses, our understanding of the key functions of the human microbiota and the molecular basis of its interactions with the host remain st …
Humans live in a permanent association with bacterial populations collectively called the microbiota. ...Despite tremendous progresse …
Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression.
Gou D, Liu R, Shan X, Deng H, Chen C, Xiang J, Liu Y, Gao Q, Li Z, Huang A, Wang K, Tang N. Gou D, et al. J Clin Invest. 2023 Jul 3;133(13):e161713. doi: 10.1172/JCI161713. J Clin Invest. 2023. PMID: 37166978 Free PMC article.
In this study, we discovered that the gluconeogenic enzyme PCK1 fueled the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransferase SUV39H1 catalyzed SAM, which served as a methyl donor to support H3K9me3 modification, lea …
In this study, we discovered that the gluconeogenic enzyme PCK1 fueled the generation of S-adenosylmethionine (SAM) through the serin …
SAMHD1 Functions and Human Diseases.
Coggins SA, Mahboubi B, Schinazi RF, Kim B. Coggins SA, et al. Viruses. 2020 Mar 31;12(4):382. doi: 10.3390/v12040382. Viruses. 2020. PMID: 32244340 Free PMC article. Review.
While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively investigated, a negative regulatory mechanism of dNTP pools was recently found to involve sterile alpha motif (SAM) domain and …
While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been exten …
Sam's Story: The Financial and Human Costs of Disjointed Logics of Care.
Karlin J. Karlin J. Ann Fam Med. 2022 Jan-Feb;20(1):84-87. doi: 10.1370/afm.2763. Ann Fam Med. 2022. PMID: 35074773 Free PMC article.
In the essay that follows, I share details from my patient Sam's (pseudonym) last 2 years of life to underscore how attending to social precarity cannot be fully achieved within our safety net institutions as they are currently structured. While we have strong evidence tha …
In the essay that follows, I share details from my patient Sam's (pseudonym) last 2 years of life to underscore how attending to soci …
PRPS2 enhances RNA m(6)A methylation by stimulating SAM synthesis through enzyme-dependent and independent mechanisms.
Zhang L, Zhao X, Hu J, Li T, Chen HZ, Zhang A, Wang H, Yu J, Zhang L. Zhang L, et al. Nat Commun. 2025 Apr 28;16(1):3966. doi: 10.1038/s41467-025-59119-0. Nat Commun. 2025. PMID: 40295500 Free PMC article.
Cancer cells exploit altered metabolic pathways to dynamically regulate epigenetic methylation and thus promote tumorigenesis and metastasis. In various human cancers, such as lung adenocarcinoma, the level of a key cellular metabolite, S-adenosylmethionine (SAM), i …
Cancer cells exploit altered metabolic pathways to dynamically regulate epigenetic methylation and thus promote tumorigenesis and metastasis …
Technical note: Generalizable and promptable artificial intelligence model to augment clinical delineation in radiation oncology.
Zhang L, Liu Z, Zhang L, Wu Z, Yu X, Holmes J, Feng H, Dai H, Li X, Li Q, Wong WW, Vora SA, Zhu D, Liu T, Liu W. Zhang L, et al. Med Phys. 2024 Mar;51(3):2187-2199. doi: 10.1002/mp.16965. Epub 2024 Feb 6. Med Phys. 2024. PMID: 38319676 Free PMC article.
SAM's box prompt mode further improves Dice scores by 0.1~0.5. Similar results were observed for Jaccard indices. The results show that SAM performs better for prostate and lung, but worse for gastrointestinal and head & neck. ...
SAM's box prompt mode further improves Dice scores by 0.1~0.5. Similar results were observed for Jaccard indices. The results show th …
SAM and folic acid prevent arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells by modulating expression of inflammatory and DNA repair genes.
Boonma T, Navasumrit P, Parnlob V, Waraprasit S, Ruchirawat M. Boonma T, et al. Chem Biol Interact. 2022 Jul 1;361:109965. doi: 10.1016/j.cbi.2022.109965. Epub 2022 Apr 28. Chem Biol Interact. 2022. PMID: 35490796
This study further investigated the ability of the methyl group donors, S-adenosyl methionine (SAM) and folic acid, to prevent promoter hypomethylation that results in decreased mRNA expression of inflammatory genes (COX2, EGR1, and SOCS3), and a reduction in arsenic-induc …
This study further investigated the ability of the methyl group donors, S-adenosyl methionine (SAM) and folic acid, to prevent promot …
26,641 results
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