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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 8
2005 18
2006 36
2007 39
2008 63
2009 72
2010 80
2011 93
2012 99
2013 149
2014 156
2015 186
2016 150
2017 153
2018 171
2019 169
2020 131
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2022 146
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2024 132
2025 133
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2,188 results

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Page 1
Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma.
You H, Zhang S, Zhang Y, Chen Q, Wu Y, Zhou Z, Zhao Z, Su B, Li X, Guo Y, Chen Y, Tang W, Liu B, Fan H, Geng S, Fang M, Li F, Liu G, Jiang C, Sun T. You H, et al. Adv Mater. 2025 Apr;37(15):e2418053. doi: 10.1002/adma.202418053. Epub 2025 Mar 4. Adv Mater. 2025. PMID: 40035513
Subsequently, immunogenic substances on OMVs, along with carried small-interfering RNA (siRNA) and doxorubicin, can promote and enhance the reprogramming and phagocytic abilities of macrophages and microglia, respectively, and increase the immunogenici …
Subsequently, immunogenic substances on OMVs, along with carried small-interfering RNA (siRNA) and doxorubicin, …
Inhalable siRNA Targeting IL-11 Nanoparticles Significantly Inhibit Bleomycin-Induced Pulmonary Fibrosis.
Dong S, Fang H, Zhu J, Wu Z, Liu Y, Zhu J, Ma B, Chen Q, Yang Y. Dong S, et al. ACS Nano. 2025 Jan 21;19(2):2742-2758. doi: 10.1021/acsnano.4c15130. Epub 2025 Jan 10. ACS Nano. 2025. PMID: 39791575
Here, we develop an innovative inhalable small interfering RNA (siRNA) delivery system termed PEI-GBZA, which demonstrates impressive efficiency in loading siIL-11 targeting IL-11 (siIL-11) and substantially suppresses the differentiation of fibroblast …
Here, we develop an innovative inhalable small interfering RNA (siRNA) delivery system termed PEI-GBZA, which de …
Pyroptotic-Spatiotemporally Selective Delivery of siRNA against Pyroptosis and Autoimmune Diseases.
Pan Z, Xu K, Huang G, Hu H, Yang H, Shen H, Qiu K, Wang C, Xu T, Yu X, Fang J, Wang J, Lin Y, Dai J, Zhong Y, Song H, Zhu S, Wang S, Zhou Z, Sun C, Tang Z, Liao S, Yang G, You Z, Dai X, Mao Z. Pan Z, et al. Adv Mater. 2024 Sep;36(38):e2407115. doi: 10.1002/adma.202407115. Epub 2024 Jul 30. Adv Mater. 2024. PMID: 39081086
Small-interfering RNAs (siRNAs) offer promising prospects for treating pyroptosis-related autoimmune diseases. ...Precision delivery and adaptive release of siRNAs into inflamed tissues and immune cells could unleash their full therapeutic potential. . …
Small-interfering RNAs (siRNAs) offer promising prospects for treating pyroptosis-related autoimmune diseases. ...Preci …
Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q. Hu L, et al. Mol Cell. 2024 Feb 15;84(4):776-790.e5. doi: 10.1016/j.molcel.2023.12.010. Epub 2024 Jan 10. Mol Cell. 2024. PMID: 38211588 Free PMC article.
In this study, we perform a kinome-wide small interfering RNA (siRNA) screen and identify doublecortin-like kinase 2 (DCLK2) as a TBK1 regulator in ccRCC. ...
In this study, we perform a kinome-wide small interfering RNA (siRNA) screen and identify doublecortin-like kina …
Nano-scale delivery systems for siRNA delivery in cancer therapy: New era of gene therapy empowered by nanotechnology.
Ebrahimi N, Manavi MS, Nazari A, Momayezi A, Faghihkhorasani F, Rasool Riyadh Abdulwahid AH, Rezaei-Tazangi F, Kavei M, Rezaei R, Mobarak H, Aref AR, Fang W. Ebrahimi N, et al. Environ Res. 2023 Dec 15;239(Pt 2):117263. doi: 10.1016/j.envres.2023.117263. Epub 2023 Oct 4. Environ Res. 2023. PMID: 37797672 Free article. Review.
However, difficulties such poor cellular uptake, off-target effects, and susceptibility to destruction by serum nucleases in the bloodstream restrict the therapeutic potential of siRNAs. Since some years ago, siRNA-based therapies have been in the process of being t …
However, difficulties such poor cellular uptake, off-target effects, and susceptibility to destruction by serum nucleases in the bloodstream …
Personalized medicine in lipid-modifying therapy.
Tomlinson B, Lin CH, Chan P, Lam CW. Tomlinson B, et al. Per Med. 2021 Mar;18(2):185-203. doi: 10.2217/pme-2020-0110. Epub 2021 Feb 10. Per Med. 2021. PMID: 33565320 Review.
Fibrates or omega-3 fatty acids can be added if triglyceride levels remain elevated. The RNA-targeted therapeutics in development offer the possibility of selective liver targeting for specific lipoproteins such as lipoprotein(a) and long-term reduction of LDL-C with infre …
Fibrates or omega-3 fatty acids can be added if triglyceride levels remain elevated. The RNA-targeted therapeutics in development off …
Ultrasound-Assisted H2 Transmitter Enables Hydrogen-Gene Therapy to Prevent Anesthesia/Surgery-Induced Cognitive Impairment.
Zhan R, Fang Y, Lou C, Chen N, Mo X, Jiao B, Liu M, Zhao Y, Xu W, Xu H, Yin H, Zhang Y. Zhan R, et al. Adv Sci (Weinh). 2025 May;12(17):e2414397. doi: 10.1002/advs.202414397. Epub 2025 Mar 6. Adv Sci (Weinh). 2025. PMID: 40047133 Free PMC article.
Utilizing focused ultrasound, the blood-brain barrier can be opened in a controlled manner, enabling the efficient delivery of hydrogen emitters (HPPS) carrying siRNA to the site of neuroinflammation. On one hand, the hydrogen emitter effectively generates hydrogen to elim …
Utilizing focused ultrasound, the blood-brain barrier can be opened in a controlled manner, enabling the efficient delivery of hydrogen emit …
RNAi in Plants: An Argonaute-Centered View.
Fang X, Qi Y. Fang X, et al. Plant Cell. 2016 Feb;28(2):272-85. doi: 10.1105/tpc.15.00920. Epub 2016 Feb 11. Plant Cell. 2016. PMID: 26869699 Free PMC article. Review.
Argonaute (AGO) family proteins are effectors of RNAi in eukaryotes. AGOs bind small RNAs and use them as guides to silence target genes or transposable elements at the transcriptional or posttranscriptional level. ...
Argonaute (AGO) family proteins are effectors of RNAi in eukaryotes. AGOs bind small RNAs and use them as guides to silence target ge …
A siRNA targets and inhibits a broad range of SARS-CoV-2 infections including Delta variant.
Chang YC, Yang CF, Chen YF, Yang CC, Chou YL, Chou HW, Chang TY, Chao TL, Hsu SC, Ieong SM, Tsai YM, Liu PC, Chin YF, Fang JT, Kao HC, Lu HY, Chang JY, Weng RS, Tu QW, Chang FY, Huang KY, Lee TY, Chang SY, Yang PC. Chang YC, et al. EMBO Mol Med. 2022 Apr 7;14(4):e15298. doi: 10.15252/emmm.202115298. Epub 2022 Feb 21. EMBO Mol Med. 2022. PMID: 35138028 Free PMC article.
The development of new therapeutics against a wide range of SARS-CoV-2 variants is imperative. We, here, have designed an inhalable siRNA, C6G25S, which covers 99.8% of current SARS-CoV-2 variants and is capable of inhibiting dominant strains, including Alpha, Delta, Gamma …
The development of new therapeutics against a wide range of SARS-CoV-2 variants is imperative. We, here, have designed an inhalable siRNA …
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis.
Lee WR, Chou WL, Lin ZC, Sung CT, Lin CY, Fang JY. Lee WR, et al. J Control Release. 2022 Jul;347:590-606. doi: 10.1016/j.jconrel.2022.05.032. Epub 2022 May 28. J Control Release. 2022. PMID: 35623494
Psoriasis is an autoimmune skin disorder presenting the excessive expression of interleukin (IL)-6. The topical use of small interfering RNA (siRNA) has been increasingly discovered for treating skin diseases. A delivery system capable of protecting …
Psoriasis is an autoimmune skin disorder presenting the excessive expression of interleukin (IL)-6. The topical use of small inter …
2,188 results