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2020 10
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Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Stroke Risk Factor Collaborators. GBD 2021 Stroke Risk Factor Collaborators. Lancet Neurol. 2024 Oct;23(10):973-1003. doi: 10.1016/S1474-4422(24)00369-7. Lancet Neurol. 2024. PMID: 39304265 Free PMC article.
FINDINGS: In 2021, stroke was the third most common GBD level 3 cause of death (7.3 million [95% UI 6.6-7.8] deaths; 10.7% [9.8-11.3] of all deaths) after ischaemic heart disease and COVID-19, and the fourth most common cause of DALYs (160.5 million [147.8-171.6] DA …
FINDINGS: In 2021, stroke was the third most common GBD level 3 cause of death (7.3 million [95% UI 6.6-7.8] deaths; 10.7% [9.8-11.3] of all …
Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050.
GBD 2021 Antimicrobial Resistance Collaborators. GBD 2021 Antimicrobial Resistance Collaborators. Lancet. 2024 Sep 28;404(10459):1199-1226. doi: 10.1016/S0140-6736(24)01867-1. Epub 2024 Sep 16. Lancet. 2024. PMID: 39299261 Free PMC article.
Given the high variability of AMR burden by location and age, it is important that interventions combine infection prevention, vaccination, minimisation of inappropriate antibiotic use in farming and humans, and research into new antibiotics to mitigate the number of AMR d …
Given the high variability of AMR burden by location and age, it is important that interventions combine infection prevention, vaccination, …
Translating IL-6 biology into effective treatments.
Choy EH, De Benedetti F, Takeuchi T, Hashizume M, John MR, Kishimoto T. Choy EH, et al. Nat Rev Rheumatol. 2020 Jun;16(6):335-345. doi: 10.1038/s41584-020-0419-z. Epub 2020 Apr 23. Nat Rev Rheumatol. 2020. PMID: 32327746 Free PMC article. Review.
Targeting this pathway has also identified avenues for potential expansion into several other indications, such as uveitis, neuromyelitis optica and, most recently, COVID-19 pneumonia. To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss …
Targeting this pathway has also identified avenues for potential expansion into several other indications, such as uveitis, neuromyelitis op …
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Disease and Injury and Risk Factor Collaborators. GBD 2023 Disease and Injury and Risk Factor Collaborators. Lancet. 2025 Oct 18;406(10513):1873-1922. doi: 10.1016/S0140-6736(25)01637-X. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092926 Free PMC article.
This work captures the evolving landscape of health metrics across age groups, sexes, and locations, while reflecting on the remaining post-COVID-19 challenges to achieving our collective global health ambitions. ...This long-observed consequence of the globa …
This work captures the evolving landscape of health metrics across age groups, sexes, and locations, while reflecting on the remainin …
The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Cancer Collaborators. GBD 2023 Cancer Collaborators. Lancet. 2025 Oct 11;406(10512):1565-1586. doi: 10.1016/S0140-6736(25)01635-6. Epub 2025 Sep 24. Lancet. 2025. PMID: 41015051 Free PMC article.
METHODS: Cancer estimation in GBD 2023 used data from population-based cancer registration systems, vital registration systems, and verbal autopsies. ...FUNDING: Gates Foundation, St Jude Children's Research Hospital, and St Baldrick's Foundation....
METHODS: Cancer estimation in GBD 2023 used data from population-based cancer registration systems, vital registration systems, and v …
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Causes of Death Collaborators. GBD 2023 Causes of Death Collaborators. Lancet. 2025 Oct 18;406(10513):1811-1872. doi: 10.1016/S0140-6736(25)01917-8. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092928 Free PMC article.
Methodological improvements for cause-of-death estimates in GBD 2023 include a correction for the misclassification of deaths due to COVID-19, updates to the method used to estimate COVID-19, and updates to the CODEm modelling framework. ...By 2023, …
Methodological improvements for cause-of-death estimates in GBD 2023 include a correction for the misclassification of deaths due to COVI …
Global, regional, and national trends in routine childhood vaccination coverage from 1980 to 2023 with forecasts to 2030: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Vaccine Coverage Collaborators. GBD 2023 Vaccine Coverage Collaborators. Lancet. 2025 Jul 19;406(10500):235-260. doi: 10.1016/S0140-6736(25)01037-2. Epub 2025 Jun 24. Lancet. 2025. PMID: 40578370 Free PMC article.
However, more recent decades have seen persistent coverage inequities and stagnating progress, which have been further amplified by the COVID-19 pandemic. In 2019, WHO set ambitious goals for improving vaccine coverage globally through the Immunization Agenda 2030 ( …
However, more recent decades have seen persistent coverage inequities and stagnating progress, which have been further amplified by the C …
Global, regional, and national sepsis incidence and mortality, 1990-2021: a systematic analysis.
GBD 2021 Global Sepsis Collaborators. GBD 2021 Global Sepsis Collaborators. Lancet Glob Health. 2025 Dec;13(12):e2013-e2026. doi: 10.1016/S2214-109X(25)00356-0. Epub 2025 Oct 21. Lancet Glob Health. 2025. PMID: 41135560 Free article.
We aimed to comprehensively estimate the global, regional, and national burden of sepsis, including the impact of the COVID-19 pandemic and underlying causes of sepsis-related deaths with co-occurring infectious syndromes. ...In 2021, bloodstream infections inclusiv …
We aimed to comprehensively estimate the global, regional, and national burden of sepsis, including the impact of the COVID-19 …
Genome-wide association study of long COVID.
Lammi V, Nakanishi T, Jones SE, Andrews SJ, Karjalainen J, Cortés B, O'Brien HE, Ochoa-Guzman A, Fulton-Howard BE, Broberg M, Haapaniemi HH, Kanai M, Pirinen M, Schmidt A, Mitchell RE, Mousas A, Mangino M, Huerta-Chagoya A, Sinnott-Armstrong N, Cirulli ET, Vaudel M, Kwong ASF, Maiti AK, Marttila MM, Posner DC, Rodriguez AA, Batini C, Minnai F, Dearman AR, Warmerdam CAR, Sequeros CB, Winkler TW, Jordan DM, Rešcenko R, Miano L, Lane JM, Chung RK, Guillen-Guio B, Leavy OC, Carvajal-Silva L, Aguilar-Valdés K, Frangione E, Guare L, Vergasova E, Marouli E, Striano P, Zainulabid UA, Kumar A, Ahmad HF, Edahiro R, Azekawa S; Long COVID Host Genetics Initiative; FinnGen; VA Million Veteran Program; MexGen-COVID Initiative; DBDS Genomic Consortium; GEN-COVID Multicenter Study; PHOSP-COVID Collaborative Group; GENCOV Study; Estonian Biobank Research Team; Luoh SW, Erikstrup C, Pedersen OBV, Lerner-Ellis J, Colombo A, Grzymski JJ, Ishii M, Okada Y, Beckmann ND, Kumari M, Wagner R, Heid IM, John C, Short PJ, Magnus P, Ansone L, Valenti LVC, Lee SA, Wain LV, Verdugo RA, Banasik K, Geller F, Franke LH, Rakitko A, Duncan EL, Renieri A, Tsilidis KK, de Cid R, Niavarani A, Abner E, Tusié-Luna T, Ver… See abstract for full author list ➔ Lammi V, et al. Nat Genet. 2025 Jun;57(6):1402-1417. doi: 10.1038/s41588-025-02100-w. Epub 2025 May 21. Nat Genet. 2025. PMID: 40399555 Free PMC article.
Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 …
Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infec …
268 results