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Page 1
Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis.
Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky DJ, Kroemer G, Liu J, Tang D, Kang R. Chen X, et al. Autophagy. 2023 Jan;19(1):54-74. doi: 10.1080/15548627.2022.2059170. Epub 2022 Apr 10. Autophagy. 2023. PMID: 35403545 Free PMC article.
These findings provide a framework for understanding how selective autophagy promotes ferroptotic cell death.Abbreviations: ANXA7: annexin A7; ARNTL: aryl hydrocarbon receptor nuclear translocator like; CCK8: cell counting kit-8; CDH2: cadherin 2; CETSAs: cellular thermal shift a …
These findings provide a framework for understanding how selective autophagy promotes ferroptotic cell death.Abbreviations: ANXA7: annexin A …
Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.
Cai T, Bai J, Tan P, Huang Z, Liu C, Wu Z, Cheng Y, Li T, Chen Y, Ruan J, Gao L, DU Y, Fu W. Cai T, et al. Oncol Res. 2023 Jul 21;31(5):805-817. doi: 10.32604/or.2023.029549. eCollection 2023. Oncol Res. 2023. PMID: 37547758 Free PMC article.
The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues. ...
The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We foun …
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
Zhou J, Zeng Y, Cui L, Chen X, Stauffer S, Wang Z, Yu F, Lele SM, Talmon GA, Black AR, Chen Y, Dong J. Zhou J, et al. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6760-E6769. doi: 10.1073/pnas.1800621115. Epub 2018 Jul 2. Proc Natl Acad Sci U S A. 2018. PMID: 29967145 Free PMC article.
However, little is known about the mechanisms by which Zyxin itself is regulated and how Zyxin affects Hippo-YAP activity. ...Mitotic phosphorylation is required for Zyxin activity in promoting growth. Zyxin regulates YAP activity through the colon can …
However, little is known about the mechanisms by which Zyxin itself is regulated and how Zyxin affects Hippo-YAP activity. ... …
Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction.
Slabodnick MM, Tintori SC, Prakash M, Zhang P, Higgins CD, Chen AH, Cupp TD, Wong T, Bowie E, Jug F, Goldstein B. Slabodnick MM, et al. PLoS Genet. 2023 Mar 28;19(3):e1010319. doi: 10.1371/journal.pgen.1010319. eCollection 2023 Mar. PLoS Genet. 2023. PMID: 36976799 Free PMC article.
We used proteomic and transcriptomic approaches to identify new players, including the candidate linkers AFD-1/afadin and ZYX-1/zyxin, as contributing to C. elegans gastrulation. We found that ZYX-1/zyxin is among a family of LIM domain proteins that have transcript …
We used proteomic and transcriptomic approaches to identify new players, including the candidate linkers AFD-1/afadin and ZYX-1/zyxin …
Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-beta signalling pathways.
Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, Chen Q, Zhu Y. Ma B, et al. Nat Commun. 2016 Mar 31;7:11123. doi: 10.1038/ncomms11123. Nat Commun. 2016. PMID: 27030211 Free PMC article.
Depletion of Zyxin impairs the capability of cell migration, proliferation and tumourigenesis in a xenograft model. Zyxin is upregulated in human breast cancer and positively correlates with histological stages and metastasis. ...
Depletion of Zyxin impairs the capability of cell migration, proliferation and tumourigenesis in a xenograft model. Zyxin is u …
Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J. Han X, et al. Nat Commun. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639. Nat Commun. 2017. PMID: 28256511 Free PMC article.
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. ...Our findings identify zyxin as a physiological regulator of endothelial exocytosis through reo …
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defe …
Zyxin-involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status.
Li G, Song X, Li R, Sun L, Gong X, Chen C, Yang L. Li G, et al. Cell Prolif. 2019 Jan;52(1):e12532. doi: 10.1111/cpr.12532. Epub 2018 Oct 17. Cell Prolif. 2019. PMID: 30328655 Free PMC article.
CONCLUSIONS: These results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the state of actin polymerization. In particular, the change of zyxin and F-actin parallels with the change of COL II and vinculin, respecti …
CONCLUSIONS: These results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the sta …
Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
Wen XM, Luo T, Jiang Y, Wang LH, Luo Y, Chen Q, Yang K, Yuan Y, Luo C, Zhang X, Yan ZX, Fu WJ, Tan YH, Niu Q, Xiao JF, Chen L, Wang J, Huang JF, Cui YH, Zhang X, Wang Y, Bian XW. Wen XM, et al. Lab Invest. 2020 Jun;100(6):812-823. doi: 10.1038/s41374-019-0368-9. Epub 2020 Jan 16. Lab Invest. 2020. PMID: 31949244 Free article.
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined that an actin-interacting protein, zyxin (ZYX), may involved in GBM invasion. Our own glioma cohort as well as the cancer genome atla …
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined …
O-GlcNAc transferase promotes the nuclear localization of the focal adhesion-associated protein Zyxin to regulate UV-induced cell death.
Zhao Y, Yue S, Zhou X, Guo J, Ma S, Chen Q. Zhao Y, et al. J Biol Chem. 2022 Apr;298(4):101776. doi: 10.1016/j.jbc.2022.101776. Epub 2022 Feb 25. J Biol Chem. 2022. PMID: 35227760 Free PMC article.
Zyxin is a zinc-binding phosphoprotein known to regulate cell migration, adhesion, and cell survival. ...Furthermore, we found that 14-3-3gamma could promote the nuclear localization of Zyxin after Ser-169 O-GlcNAcylation by affecting the function of the N-terminal …
Zyxin is a zinc-binding phosphoprotein known to regulate cell migration, adhesion, and cell survival. ...Furthermore, we found that 1 …
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.
Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA. Kato T, et al. J Clin Invest. 2005 Oct;115(10):2716-30. doi: 10.1172/JCI24280. J Clin Invest. 2005. PMID: 16200208 Free PMC article.
Nuclear translocation of zyxin triggered by cGMP also promotes nuclear Akt accumulation. Additional supportive evidence for nuclear accumulation of zyxin-enhancing cardiomyocyte survival includes the following: (a) promotion of zyxin nuclear localization by c …
Nuclear translocation of zyxin triggered by cGMP also promotes nuclear Akt accumulation. Additional supportive evidence for nuclear a …
30 results