Overlapping functions between Lamp2a and Lamp2b in cardiac autophagy.
Sampaio Cruz M, Manso AM, Soto-Hermida A, Bushway P, Silver E, Gunes BB, Tang Z, Gonzalez G, Lau S, Arbayo J, Najor RH, Chi L, Gu Y, Feng W, Cowling RT, Gustafsson AB, Chen J, Adler ED.
Sampaio Cruz M, et al.
Autophagy. 2025 Sep;21(9):2046-2057. doi: 10.1080/15548627.2025.2484620. Epub 2025 Apr 9.
Autophagy. 2025.
PMID: 40202173
Free PMC article.
Overall, these data support LAMP2 isoform functional redundancy in the myocardium under pathological conditions.Abbreviations: AAV: adeno-associated virus; ACTA2: actin alpha 2, smooth muscle, aorta; CMA: chaperone-mediated autophagy; KO: knockout; LAMP2: lysosomal-associated mem …
Overall, these data support LAMP2 isoform functional redundancy in the myocardium under pathological conditions.Abbreviations: AAV: adeno-as …