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Page 1
Evaluation of surgical procedures for sex reassignment: a systematic review.
Sutcliffe PA, Dixon S, Akehurst RL, Wilkinson A, Shippam A, White S, Richards R, Caddy CM. Sutcliffe PA, et al. J Plast Reconstr Aesthet Surg. 2009 Mar;62(3):294-306; discussion 306-8. doi: 10.1016/j.bjps.2007.12.009. Epub 2008 Jan 28. J Plast Reconstr Aesthet Surg. 2009. PMID: 18222742 Review.
CONCLUSIONS: The evidence concerning gender reassignment surgery in both MTF and FTM transsexism has several limitations in terms of: (a) lack of controlled studies, (b) evidence has not collected data prospectively, (c) high loss to follow up and (d) lack of validated ass …
CONCLUSIONS: The evidence concerning gender reassignment surgery in both MTF and FTM transsexism has several limitations in terms of: (a) la …
Differential gene expression in obese pregnancy.
Carty D, Akehurst C, Savage R, Sungatullina L, Robinson S, McBride M, McClure J, Freeman D, Delles C. Carty D, et al. Pregnancy Hypertens. 2014 Jul;4(3):232-3. doi: 10.1016/j.preghy.2014.03.011. Epub 2014 Jul 9. Pregnancy Hypertens. 2014. PMID: 26104615
When gene expression was studied in subcutaneous tissues, we observed a trend towards lower expression of the cytochrome c oxidase-subunit 7A2 gene (COX7A2) in overweight vs lean (p=0.057) and obese vs lean (p=0.06) women, whereas expression was similar between overweight …
When gene expression was studied in subcutaneous tissues, we observed a trend towards lower expression of the cytochrome c oxidase-su …
A Framework for Developing the Structure of Public Health Economic Models.
Squires H, Chilcott J, Akehurst R, Burr J, Kelly MP. Squires H, et al. Value Health. 2016 Jul-Aug;19(5):588-601. doi: 10.1016/j.jval.2016.02.011. Epub 2016 Apr 23. Value Health. 2016. PMID: 27565276 Free article.
The methodology consists of four phases: phase A, aligning the framework with the decision-making process; phase B, identifying relevant stakeholders; phase C, understanding the problem; and phase D, developing and justifying the model structure. ...
The methodology consists of four phases: phase A, aligning the framework with the decision-making process; phase B, identifying relevant sta …
Incorporation of uncertainty in health economic modelling studies.
O'Hagan A, McCabe C, Akehurst R, Brennan A, Briggs A, Claxton K, Fenwick E, Fryback D, Sculpher M, Spiegelhalter D, Willan A. O'Hagan A, et al. Pharmacoeconomics. 2005;23(6):529-36. doi: 10.2165/00019053-200523060-00001. Pharmacoeconomics. 2005. PMID: 15960550
His proposals are found to suffer from serious flaws in statistical and health economic reasoning.Nuijten's suggestions for incorporating uncertainty: (a) wrongly interpret the p-value as the probability that the null hypothesis is true; (b) represent this probability wrongly by …
His proposals are found to suffer from serious flaws in statistical and health economic reasoning.Nuijten's suggestions for incorporating un …
Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.
Bebee TW, Dominguez CE, Samadzadeh-Tarighat S, Akehurst KL, Chandler DS. Bebee TW, et al. Hum Mol Genet. 2012 Oct 1;21(19):4301-13. doi: 10.1093/hmg/dds263. Epub 2012 Jul 3. Hum Mol Genet. 2012. PMID: 22763238 Free PMC article.
Reduced levels of SMN is due to the loss of the SMN1 gene and inefficient splicing of the SMN2 gene caused by a C>T mutation in exon 7. Global analysis of the severe SMNdelta7 SMA mouse model revealed altered splicing and increased levels of the hypoxia-inducible transc …
Reduced levels of SMN is due to the loss of the SMN1 gene and inefficient splicing of the SMN2 gene caused by a C>T mutation in ex …