[Alveolar hemorrhage in pulmonary-renal syndrome anti-SCL/70 and anti-MPO-ANCA positive]

Recenti Prog Med. 2009 Jul-Aug;100(7-8):361-4.
[Article in Italian]

Abstract

We describe a case of pulmonary-renal syndrome on autoimmune basis, with alveolar hemorrhage and worsening renal failure. The patient was positive for anti-MPO and anti-SCL/70. Immunosuppressive therapy was effective to treat the pulmonary condition, but chronic renal failure emerged. The clinical condition did not improve after plasmapheresis, thus chronic dialysis was required.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic / blood*
  • Antibodies, Antinuclear / blood*
  • Biomarkers / blood
  • DNA Topoisomerases, Type I
  • Female
  • Glomerulonephritis, Membranoproliferative / blood
  • Glomerulonephritis, Membranoproliferative / complications
  • Glomerulonephritis, Membranoproliferative / immunology*
  • Glomerulonephritis, Membranoproliferative / pathology
  • Glomerulonephritis, Membranoproliferative / therapy
  • Hemorrhage / immunology*
  • Hemorrhage / therapy
  • Humans
  • Immunologic Factors / blood*
  • Immunosuppressive Agents / therapeutic use
  • Lung Diseases / blood
  • Lung Diseases / complications
  • Lung Diseases / immunology*
  • Lung Diseases / pathology
  • Lung Diseases / therapy
  • Lung Diseases, Interstitial / immunology
  • Nuclear Proteins / blood*
  • Plasmapheresis
  • Pulmonary Alveoli* / pathology
  • Renal Dialysis / methods
  • Scleroderma, Systemic / complications
  • Syndrome
  • Treatment Outcome

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Antibodies, Antinuclear
  • Biomarkers
  • Immunologic Factors
  • Immunosuppressive Agents
  • Nuclear Proteins
  • Scl 70 antigen, human
  • DNA Topoisomerases, Type I