Abstract
We describe a case of pulmonary-renal syndrome on autoimmune basis, with alveolar hemorrhage and worsening renal failure. The patient was positive for anti-MPO and anti-SCL/70. Immunosuppressive therapy was effective to treat the pulmonary condition, but chronic renal failure emerged. The clinical condition did not improve after plasmapheresis, thus chronic dialysis was required.
MeSH terms
-
Adult
-
Antibodies, Antineutrophil Cytoplasmic / blood*
-
Antibodies, Antinuclear / blood*
-
Biomarkers / blood
-
DNA Topoisomerases, Type I
-
Female
-
Glomerulonephritis, Membranoproliferative / blood
-
Glomerulonephritis, Membranoproliferative / complications
-
Glomerulonephritis, Membranoproliferative / immunology*
-
Glomerulonephritis, Membranoproliferative / pathology
-
Glomerulonephritis, Membranoproliferative / therapy
-
Hemorrhage / immunology*
-
Hemorrhage / therapy
-
Humans
-
Immunologic Factors / blood*
-
Immunosuppressive Agents / therapeutic use
-
Lung Diseases / blood
-
Lung Diseases / complications
-
Lung Diseases / immunology*
-
Lung Diseases / pathology
-
Lung Diseases / therapy
-
Lung Diseases, Interstitial / immunology
-
Nuclear Proteins / blood*
-
Plasmapheresis
-
Pulmonary Alveoli* / pathology
-
Renal Dialysis / methods
-
Scleroderma, Systemic / complications
-
Syndrome
-
Treatment Outcome
Substances
-
Antibodies, Antineutrophil Cytoplasmic
-
Antibodies, Antinuclear
-
Biomarkers
-
Immunologic Factors
-
Immunosuppressive Agents
-
Nuclear Proteins
-
Scl 70 antigen, human
-
DNA Topoisomerases, Type I