Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition.
Panzhinskiy E, Skovsø S, Cen HH, Rahardjo A, Zhang JA, Chu KY, MacDonald K, Soukhatcheva G, Dionne DA, Hallmaier-Wacker LK, Wildi JS, Marcil S, Noursadeghi N, Taghizadeh F, Verchere CB, Jan E, Johnson JD.
Panzhinskiy E, et al.
Diabetologia. 2025 Aug;68(8):1735-1753. doi: 10.1007/s00125-025-06431-5. Epub 2025 Apr 30.
Diabetologia. 2025.
PMID: 40304759
EIF2A overexpression significantly increased expression of genes involved in mRNA translation and reduced expression of pro-apoptotic genes (e.g. Aldh1a3). Proteomic analysis of EIF2A-overexpressing human islets revealed significant changes in pathways associated with ribo …
EIF2A overexpression significantly increased expression of genes involved in mRNA translation and reduced expression of pro-apoptotic genes …