TRPA1 activation prompts lysosome-mediated Nrf2 degradation enhancing the killing of colorectal cancer cells.
Eskandari N, Delisi D, Vakili Saatloo M, Keceli G, Pinheiro N, Eblen S, Paolocci N, Gentile S.
Eskandari N, et al.
Redox Biol. 2025 Dec;88:103942. doi: 10.1016/j.redox.2025.103942. Epub 2025 Nov 25.
Redox Biol. 2025.
PMID: 41330216
Free PMC article.
Proteasome inhibition failed to rescue NRF2, whereas bafilomycin A1 restored its levels and blocked co-localization with lysosomal markers (e.g., LAMP2A). Importantly, CBD-induced TRPA1 activation sensitized CRC cells to oxaliplatin, triggering apoptotic-not senescent-cell …
Proteasome inhibition failed to rescue NRF2, whereas bafilomycin A1 restored its levels and blocked co-localization with lysosomal markers ( …