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Page 1
Tumor growth inhibition modeling to support the starting dose for dacomitinib.
Fostvedt LK, Nickens DJ, Tan W, Parivar K. Fostvedt LK, et al. CPT Pharmacometrics Syst Pharmacol. 2022 Sep;11(9):1256-1267. doi: 10.1002/psp4.12841. Epub 2022 Aug 6. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35818811 Free PMC article.
The TGI model characterized the tumor inhibition over time with constant growth rate (k(L) = 0.0012 years(-1) ) and highly variable kill rate (k(D) = 1.002 years(-1) /[mug/L](thetacavg) , coefficient of variation [CV] = 89%) and drug resistance (lambda = 14.47 yea …
The TGI model characterized the tumor inhibition over time with constant growth rate (k(L) = 0.0012 years(-1) ) and highly variable …
Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase.
Najafian M, Ebrahim-Habibi A, Hezareh N, Yaghmaei P, Parivar K, Larijani B. Najafian M, et al. Mol Biol Rep. 2011 Mar;38(3):1617-20. doi: 10.1007/s11033-010-0271-3. Epub 2010 Sep 21. Mol Biol Rep. 2011. PMID: 20857221
Porcine pancreatic alpha-amylase was observed to be effectively inhibited by this compound, which showed competitive behavior with a K(i) of 48 muM. Soluble starch (the natural substrate of the enzyme) was used in this study in order to obtain more realistic results. ...
Porcine pancreatic alpha-amylase was observed to be effectively inhibited by this compound, which showed competitive behavior with a K …
The effect of extracellular matrix on embryonic stem cell-derived cardiomyocytes.
Baharvand H, Azarnia M, Parivar K, Ashtiani SK. Baharvand H, et al. J Mol Cell Cardiol. 2005 Mar;38(3):495-503. doi: 10.1016/j.yjmcc.2004.12.011. J Mol Cell Cardiol. 2005. PMID: 15733909
However, the change in beating was similar in all groups upon treatment with phenylephrine and/or Bay-K. Ultrastructure analysis showed myofibrillar bundle organization and exhibited intercalated discs, T-tubules, Z-, A-, I-, H- and M-bands and the showed earlier maturatio …
However, the change in beating was similar in all groups upon treatment with phenylephrine and/or Bay-K. Ultrastructure analysis show …
Stability and activity improvement of horseradish peroxidase by covalent immobilization on functionalized reduced graphene oxide and biodegradation of high phenol concentration.
Besharati Vineh M, Saboury AA, Poostchi AA, Rashidi AM, Parivar K. Besharati Vineh M, et al. Int J Biol Macromol. 2018 Jan;106:1314-1322. doi: 10.1016/j.ijbiomac.2017.08.133. Epub 2017 Aug 26. Int J Biol Macromol. 2018. PMID: 28851646
The covalent bonding process was applied to immobilize horseradish peroxidase (HRP) onto a functionalized reduced graphene oxide with size of 60nm through glutaraldehyde as a cross-linker. The catalytic constant, k(cat), and the catalytic efficiency, k(cat)/K …
The covalent bonding process was applied to immobilize horseradish peroxidase (HRP) onto a functionalized reduced graphene oxide with size o …