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Page 1
Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier.
Shin JW, An S, Kim D, Kim H, Ahn J, Eom J, You WK, Yun H, Lee B, Sung B, Jung J, Kim S, Son Y, Sung E, Lee H, Lee S, Song D, Pak Y, Sandhu JK, Haqqani AS, Stanimirovic DB, Yoo J, Kim D, Maeng S, Lee J, Lee SH. Shin JW, et al. Cell Rep Methods. 2022 Nov 21;2(11):100338. doi: 10.1016/j.crmeth.2022.100338. eCollection 2022 Nov 21. Cell Rep Methods. 2022. PMID: 36452865 Free PMC article.
Real-world experience with the pentaspline pulsed field ablation system: one-year outcomes of the FARADISE registry.
Boersma LVA, Széplaki G, Dello Russo A, García-Bolao I, Efremidis M, Szegedi N, Willems S, Haqqani H, Gandjbakhch E, Solimene F, Andrikopoulos G, Fiala M, Defaye P, Luik A, Lugenbiel P, Eckardt L, Ouss A, Herzet JM, Maqueda JR, Abbey S, Osca J, Hussin A, Cielen N, Johnson M, Albrecht EM, Sutton BS, Vijgen J. Boersma LVA, et al. Europace. 2025 Sep 1;27(9):euaf182. doi: 10.1093/europace/euaf182. Europace. 2025. PMID: 40888735 Free PMC article.
Safety and effectiveness of the first balloon-in-basket pulsed field ablation system for the treatment of atrial fibrillation: VOLT CE Mark Study 6-month results.
Tilz RR, Chierchia GB, Gunawardene M, Sanders P, Haqqani H, Kalman J, Healy S, Pürerfellner H, Neuzil P, Asensi JO, Loh P, Reddy VY, Knecht S, Jesser E, Dirckx N, Miller A, Walker D, Lakkireddy D. Tilz RR, et al. Europace. 2025 Mar 28;27(4):euaf072. doi: 10.1093/europace/euaf072. Europace. 2025. PMID: 40163671 Free PMC article. Clinical Trial.
Is perioperative COVID-19 really associated with worse surgical outcomes? A nationwide COVIDSurg propensity-matched analysis.
Argandykov D, Dorken-Gallastegi A, El Moheb M, Gebran A, Proaño-Zamudio JA, Bokenkamp M, Renne AM, Nepogodiev D, Bhangu A, Kaafarani HMA; COVIDSurg Collaborative. Argandykov D, et al. J Trauma Acute Care Surg. 2023 Apr 1;94(4):513-524. doi: 10.1097/TA.0000000000003859. Epub 2023 Jan 19. J Trauma Acute Care Surg. 2023. PMID: 36949053 Free PMC article.
Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.
Kang MS, Shin M, Ottoy J, Aliaga AA, Mathotaarachchi S, Quispialaya K, Pascoal TA, Collins DL, Chakravarty MM, Mathieu A, Sandelius Å, Blennow K, Zetterberg H, Massarweh G, Soucy JP, Cuello AC, Gauthier S, Waterston M, Yoganathan N, Lessard E, Haqqani A, Rennie K, Stanimirovic D, Chakravarthy B, Rosa-Neto P. Kang MS, et al. J Cereb Blood Flow Metab. 2022 May;42(5):788-801. doi: 10.1177/0271678X211035625. Epub 2021 Aug 11. J Cereb Blood Flow Metab. 2022. PMID: 34378436 Free PMC article.
Finally, FC5-mFc2a-ABP (referred to as KG207-M) treatment did not induce amyloid-related imaging abnormalities such as microhemorrhage. ...
Finally, FC5-mFc2a-ABP (referred to as KG207-M) treatment did not induce amyloid-related imaging abnormalities such as microhemorrhag …
Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion.
See Hoe LE, Bouquet M, Bartnikowski N, Wells MA, Devaux J, Hyslop K, Passmore MR, Wilson ES, Reid JD, O'Neill H, Shuker T, Obonyo NG, Sato K, Heinsar S, Wildi K, Ainola C, Abbate G, Peart JN, Wendt L, Engkilde-Pedersen S, Parker SE, Lu L, White N, Molenaar P, Li Bassi G, Haqqani H, McGiffin DC, Suen JY, Fraser JF. See Hoe LE, et al. Transplantation. 2025 Dec 1;109(12):e697-e707. doi: 10.1097/TP.0000000000005490. Epub 2025 Jul 22. Transplantation. 2025. PMID: 40691830
Targeting insulin-like growth factor-1 receptor (IGF1R) for brain delivery of biologics.
Alata W, Yogi A, Brunette E, Delaney CE, van Faassen H, Hussack G, Iqbal U, Kemmerich K, Haqqani AS, Moreno MJ, Stanimirovic DB. Alata W, et al. FASEB J. 2022 Mar;36(3):e22208. doi: 10.1096/fj.202101644R. FASEB J. 2022. PMID: 35192204
The concentration curve for IGF1R4-mFc demonstrated a linear accumulation plateauing at approximately 400 g (~1 M), suggesting a saturable mechanism of transport. Capillary depletion and mass spectrometry analyses of brain parenchyma post-ISBP confirmed the IGF1R4-mFc br …
The concentration curve for IGF1R4-mFc demonstrated a linear accumulation plateauing at approximately 400 g (~1 M), suggesting a sa …
Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells.
Alpuche-Lazcano SP, Stuible M, Akache B, Tran A, Kelly J, Hrapovic S, Robotham A, Haqqani A, Star A, Renner TM, Blouin J, Maltais JS, Cass B, Cui K, Cho JY, Wang X, Zoubchenok D, Dudani R, Duque D, McCluskie MJ, Durocher Y. Alpuche-Lazcano SP, et al. Commun Med (Lond). 2023 Aug 23;3(1):116. doi: 10.1038/s43856-023-00340-7. Commun Med (Lond). 2023. PMID: 37612423 Free PMC article.
Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (-)-noradrenaline.
Dashwood A, Cheesman E, Wong YW, Haqqani H, Beard N, Hay K, Spratt M, Chan W, Molenaar P. Dashwood A, et al. Pharmacol Res Perspect. 2021 May;9(3):e00760. doi: 10.1002/prp2.760. Pharmacol Res Perspect. 2021. PMID: 33929079 Free PMC article.

OM prolonged TPF and t(50%) in ventricular trabeculae (600 nM, 2 M, p < .001). OM had no significant inotropic effect but reduced time dependent deterioration in contractile strength compared to control (p < .001). ...The potency of (-)-noradrenaline (pEC(50) 6.05

…

OM prolonged TPF and t(50%) in ventricular trabeculae (600 nM, 2 M, p < .001). OM had no significant inotropic effect but reduced

…
Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer's Disease in Rat and Dog.
Lessard E, Rennie K, Haqqani A, Ling B, Whitfield J, Paradis A, Araujo J, Yoganathan N, Gillard J, Stanimirovic D, Chakravarthy B. Lessard E, et al. Pharm Res. 2022 Jul;39(7):1497-1507. doi: 10.1007/s11095-022-03285-z. Epub 2022 Jun 15. Pharm Res. 2022. PMID: 35704250 Free PMC article.
The bi-functional fusion protein, FC5-mFc-ABP (KG207-M) lowered both CSF and brain Ass levels after systemic dosing in transgenic mouse and rat models of Alzheimer's disease (AD). ...
The bi-functional fusion protein, FC5-mFc-ABP (KG207-M) lowered both CSF and brain Ass levels after systemic dosing in transgenic mou …
13 results