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96 results

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Page 1
Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis.
Khalafi M, Dartora WJ, McIntire LBJ, Butler TA, Wartchow KM, Hojjati SH, Razlighi QR, Shirbandi K, Zhou L, Chen K, Xi K, Banerjee S, Foldi N, Pahlajani S, Glodzik L, Li Y, de Leon MJ, Chiang GC. Khalafi M, et al. Alzheimers Dement. 2025 Feb;21(2):e14458. doi: 10.1002/alz.14458. Epub 2024 Dec 23. Alzheimers Dement. 2025. PMID: 39711334 Free PMC article.
CSF p-tau217 had 79% sensitivity for amyloid and 91% for tau, with 91% and 84% specificity. p-tau217 effectively identifies Alzheimer's disease (AD) pathology. Plasma p-tau217 was comparable to CSF p-tau217 in detecting amyloid deposition on PET. ...Plasma p-tau217 accurat …
CSF p-tau217 had 79% sensitivity for amyloid and 91% for tau, with 91% and 84% specificity. p-tau217 effectively identifies Alzheimer's …
Inter-network functional connectivity increases by beta-amyloid and may facilitate the early stage of tau accumulation.
Hojjati SH, Butler TA, de Leon M, Gupta A, Nayak S, Luchsinger JA, Razlighi QR, Chiang GC. Hojjati SH, et al. Neurobiol Aging. 2025 Apr;148:16-26. doi: 10.1016/j.neurobiolaging.2025.01.005. Epub 2025 Jan 26. Neurobiol Aging. 2025. PMID: 39879839
Alzheimer's disease (AD) is pathologically marked by tau tangles and beta-amyloid (Abeta) plaques. ...
Alzheimer's disease (AD) is pathologically marked by tau tangles and beta-amyloid (Abeta) plaques. ...
Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease.
Butler T, Wang X, Chiang G, Xi K, Niogi S, Glodzik L, Li Y, Razlighi QR, Zhou L, Hojjati SH, Ozsahin I, Mao X, Maloney T, Tanzi E, Rahmouni N, Tissot C, Lussier F, Shah S, Shungu D, Gupta A, De Leon M, Mozley PD, Pascoal TA, Rosa-Neto P. Butler T, et al. J Alzheimers Dis. 2024;99(1):307-319. doi: 10.3233/JAD-231312. J Alzheimers Dis. 2024. PMID: 38669537 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) pathology is considered to begin in the brainstem, and cerebral microglia are known to play a critical role in AD pathogenesis, yet little is known about brainstem microglia in AD. ...
BACKGROUND: Alzheimer's disease (AD) pathology is considered to begin in the brainstem, and cerebral microglia are known to play a cr …
Heterogeneous tau deposition patterns in the preclinical stage link to domain-specific cognitive deficits.
Hojjati SH, Chiang GC, Butler TA, Chen K, Khalafi M, Yazdi BG, Foldi N, Nayak S, de Leon M, Li Y, Stern Y, Luchsinger JA, Razlighi QR. Hojjati SH, et al. Alzheimers Dement. 2025 May;21(5):e70153. doi: 10.1002/alz.70153. Alzheimers Dement. 2025. PMID: 40355988 Free PMC article.
INTRODUCTION: The spatial heterogeneity of tau deposition is closely linked to clinical variants of Alzheimer's disease (AD). Detecting these patterns in the preclinical stage is challenging, but second-generation tau tracers provide a unique opportunity to do so. ...
INTRODUCTION: The spatial heterogeneity of tau deposition is closely linked to clinical variants of Alzheimer's disease (AD). Detecti …
Prediction and Modeling of Neuropsychological Scores in Alzheimer's Disease Using Multimodal Neuroimaging Data and Artificial Neural Networks.
Hojjati SH, Babajani-Feremi A; Alzheimer’s Disease Neuroimaging Initiative. Hojjati SH, et al. Front Comput Neurosci. 2022 Jan 6;15:769982. doi: 10.3389/fncom.2021.769982. eCollection 2021. Front Comput Neurosci. 2022. PMID: 35069161 Free PMC article.
Background: In recent years, predicting and modeling the progression of Alzheimer's disease (AD) based on neuropsychological tests has become increasingly appealing in AD research. ...We predicted two neuropsychological scores, i.e., the clinical dementia rating sum of box …
Background: In recent years, predicting and modeling the progression of Alzheimer's disease (AD) based on neuropsychological tests ha …
Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers.
Ozsahin I, Wang X, Zhou L, Xi K, Hojjati SH, Tanzi E, Maloney T, Fung EK, Dyke JP, Chen K, Pahlajani S, McIntire LB, Costa AP, Dartora WJ, Razlighi QR, Glodzik L, Li Y, Chiang GC, Rusinek H, de Leon MJ, Butler TA. Ozsahin I, et al. Sci Rep. 2025 Apr 14;15(1):12818. doi: 10.1038/s41598-025-97409-1. Sci Rep. 2025. PMID: 40229453 Free PMC article.
CP dysfunction is implicated in Alzheimer's Disease (AD), with MRI studies showing CP enlargement in AD. The basis for CP enlargement is unknown. ...
CP dysfunction is implicated in Alzheimer's Disease (AD), with MRI studies showing CP enlargement in AD. The basis for CP enlargement …
96 results