Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole

A R Jalilian; P Rowshanfarzad; H Afarideh; A Shafiee; M Sabet; M Kyoumarsi; Gh R Raisali

doi:10.1016/j.apradiso.2003.11.091

Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole

Appl Radiat Isot. 2004 May;60(5):659-63. doi: 10.1016/j.apradiso.2003.11.091.

Authors

A R Jalilian¹, P Rowshanfarzad, H Afarideh, A Shafiee, M Sabet, M Kyoumarsi, Gh R Raisali

Affiliation

¹ Cyclotron Department, Nuclear Research Center for Agriculture & Medicine, P.O. Box 31585-4395, Karaj, Iran. amirreza.jalilian@yale.edu

PMID: 15082043
DOI: 10.1016/j.apradiso.2003.11.091

Abstract

Selenium-75 (t1/2 = 120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35 microCi/microAh; maximum current, 6 microA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50 degrees C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.

MeSH terms

Arsenic Trioxide
Arsenicals / chemistry
Azoles / chemical synthesis
Azoles / chemistry*
Chromatography, Thin Layer
Organoselenium Compounds / chemical synthesis*
Oxidation-Reduction
Oxides / chemistry
Protons
Radiochemistry
Radiopharmaceuticals / chemical synthesis*
Selenium Radioisotopes / chemistry*
Temperature

Substances

Arsenicals
Azoles
Organoselenium Compounds
Oxides
Protons
Radiopharmaceuticals
Selenium Radioisotopes
Arsenic Trioxide