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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2002 1
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2004 2
2005 1
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2008 1
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2010 3
2011 1
2012 8
2013 3
2015 2
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38 results

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The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
Das R, Melo JA, Thondamal M, Morton EA, Cornwell AB, Crick B, Kim JH, Swartz EW, Lamitina T, Douglas PM, Samuelson AV. Das R, et al. Among authors: lamitina t. PLoS Genet. 2017 Oct 16;13(10):e1007038. doi: 10.1371/journal.pgen.1007038. eCollection 2017 Oct. PLoS Genet. 2017. PMID: 29036198 Free PMC article.
We demonstrate that constitutive expression of the sole Caenorhabditis elegans Hipk homolog, hpk-1, is sufficient to delay aging, preserve proteostasis, and promote stress resistance, while loss of hpk-1 is deleterious to these phenotypes. ...
We demonstrate that constitutive expression of the sole Caenorhabditis elegans Hipk homolog, hpk-1, is sufficient to delay aging, pre …
The C. elegans Hypertonic Stress Response: Big Insights from Shrinking Worms.
Urso SJ, Lamitina T. Urso SJ, et al. Among authors: lamitina t. Cell Physiol Biochem. 2021 Feb 25;55(S1):89-105. doi: 10.33594/000000332. Cell Physiol Biochem. 2021. PMID: 33626269 Free PMC article. Review.
However, many unanswered questions remain regarding the nature of cell volume 'sensing' as well as the molecular signaling pathways involved in activating physiological response mechanisms. Unbiased genetic screening in the model organism C. elegans is providing new and un …
However, many unanswered questions remain regarding the nature of cell volume 'sensing' as well as the molecular signaling pathways involved …
Models and mechanisms of repeat expansion disorders: a worm's eye view.
Rudich P, Lamitina T. Rudich P, et al. Among authors: lamitina t. J Genet. 2018 Jul;97(3):665-677. J Genet. 2018. PMID: 30027902 Free PMC article. Review.
However, a new phenomenon termed 'repeat-associated nonAUG dependent (RAN) translation' paints a new and unifying picture of how distinct repeat expansion-bearing RNAs might act as substrates for this noncanonical form of translation, leading to the production of a wide range of …
However, a new phenomenon termed 'repeat-associated nonAUG dependent (RAN) translation' paints a new and unifying picture of how distinct re …
Measuring RAN Peptide Toxicity in C. elegans.
Rudich P, Snoznik C, Puleo N, Lamitina T. Rudich P, et al. Among authors: lamitina t. J Vis Exp. 2020 Apr 30;(158):10.3791/61024. doi: 10.3791/61024. J Vis Exp. 2020. PMID: 32420986 Free PMC article.
C. elegans is commonly used to model age-related neurodegenerative diseases caused by repeat expansion mutations, such as Amyotrophic Lateral Sclerosis (ALS) and Huntington's disease. ...In this paper, we present strategies to measure the toxicity of RAN peptides in the mo …
C. elegans is commonly used to model age-related neurodegenerative diseases caused by repeat expansion mutations, such as Amyotrophic …
Length-dependent RNA foci formation and Repeat Associated non-AUG dependent translation in a C. elegans G (4) C (2) model.
Lamitina T. Lamitina T. MicroPubl Biol. 2022 Jul 15;2022:10.17912/micropub.biology.000600. doi: 10.17912/micropub.biology.000600. eCollection 2022. MicroPubl Biol. 2022. PMID: 35903771 Free PMC article.
GC-rich repeat expansion mutations are implicated in several neurodegenerative diseases and can lead to repeat associated non-AUG-dependent (RAN) translation and concentrations of nuclear RNA foci. To model C9orf72 ALS/FTD, we engineered C. elegans to express pure GGGGCC ( …
GC-rich repeat expansion mutations are implicated in several neurodegenerative diseases and can lead to repeat associated non-AUG-dependent …
The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.
Snoznik C, Medvedeva V, Mojsilovic-Petrovic J, Rudich P, Oosten J, Kalb RG, Lamitina T. Snoznik C, et al. Among authors: lamitina t. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2104664118. doi: 10.1073/pnas.2104664118. Epub 2021 Sep 30. Proc Natl Acad Sci U S A. 2021. PMID: 34593637 Free PMC article.
Previously, we showed that the DPRs PR50 and GR50 are highly toxic when expressed in Caenorhabditis elegans, and this toxicity depends on nuclear localization of the DPR. ...Finally, we find that knockdown of bromodomain proteins in both C. elegans and mammalian neu …
Previously, we showed that the DPRs PR50 and GR50 are highly toxic when expressed in Caenorhabditis elegans, and this toxicity depend …
Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.
Yan X, Xing J, Lorin-Nebel C, Estevez AY, Nehrke K, Lamitina T, Strange K. Yan X, et al. Among authors: lamitina t. J Gen Physiol. 2006 Oct;128(4):443-59. doi: 10.1085/jgp.200609611. Epub 2006 Sep 11. J Gen Physiol. 2006. PMID: 16966474 Free PMC article.
1,4,5-trisphosphate (IP(3))-dependent Ca(2+) signaling regulates gonad function, fertility, and rhythmic posterior body wall muscle contraction (pBoc) required for defecation in Caenorhabditis elegans. Store-operated Ca(2+) entry (SOCE) is activated during endoplasmic reti …
1,4,5-trisphosphate (IP(3))-dependent Ca(2+) signaling regulates gonad function, fertility, and rhythmic posterior body wall muscle contract …
To UPR and beyond! A new role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis.
Lamitina T, Chevet E. Lamitina T, et al. Virulence. 2012 May 1;3(3):238-40. doi: 10.4161/viru.20794. Epub 2012 May 1. Virulence. 2012. PMID: 22665168 Free PMC article.
The fungal pathogen Drechmeria coniospora infects C. elegans and elicits an innate immune response mediated, in part, by the induction of antimicrobial peptides in the epidermis. ...In this issue of Virulence, Couillault and colleagues use both proteomics and genetics to d …
The fungal pathogen Drechmeria coniospora infects C. elegans and elicits an innate immune response mediated, in part, by the inductio …
Functional genomic approaches in C. elegans.
Lamitina T. Lamitina T. Methods Mol Biol. 2006;351:127-38. doi: 10.1385/1-59745-151-7:127. Methods Mol Biol. 2006. PMID: 16988431 Review.
The nematode Caenorhabditis elegans is an extraordinarily powerful model organism for the application of functional genomic approaches. Two such approaches, whole genome microarray analysis and genome-wide RNA interference (RNAi)-mediated phenotypic screening, are highly a …
The nematode Caenorhabditis elegans is an extraordinarily powerful model organism for the application of functional genomic approache …
FER-1/Dysferlin promotes cholinergic signaling at the neuromuscular junction in C. elegans and mice.
Krajacic P, Pistilli EE, Tanis JE, Khurana TS, Lamitina ST. Krajacic P, et al. Among authors: lamitina st. Biol Open. 2013 Oct 15;2(11):1245-52. doi: 10.1242/bio.20135637. eCollection 2013. Biol Open. 2013. PMID: 24244862 Free PMC article.
We found that both loss-of-function mutations and muscle-specific overexpression of C. elegans fer-1, the founding member of the Dysferlin gene family, caused defects in muscle cholinergic signaling. ...
We found that both loss-of-function mutations and muscle-specific overexpression of C. elegans fer-1, the founding member of the Dysf …
38 results