Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034.
Sahi J, Sinz MW, Campbell S, Mireles R, Zheng X, Rose KA, Raeissi S, Hashim MF, Ye Y, de Morais SM, Black C, Tugnait M, Keller LH.
Sahi J, et al.
Chem Biol Interact. 2006 Feb 1;159(2):156-68. doi: 10.1016/j.cbi.2005.11.001. Epub 2005 Dec 13.
Chem Biol Interact. 2006.
PMID: 16356485
Clinical Trial.
We next evaluated the in vitro inhibition potential of CI-1034 with the major hepatic transporters OATP1B1, OATP1B3, OATP2B1, MDR1, MRP2 and OCT. CI-1034 inhibited OATP1B1 (K(i) 2 microM), OATP1B3 (K(i) 1.8 microM) and OATP2B1 activity (K(i) 3.3 microM) but n …
We next evaluated the in vitro inhibition potential of CI-1034 with the major hepatic transporters OATP1B1, OATP1B3, OATP2B1, MDR1, MRP2 and …