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2018 20
2019 2
2022 0
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PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance.
Wen JJ, Yin YW, Garg NJ. Wen JJ, et al. PLoS Pathog. 2018 May 31;14(5):e1007065. doi: 10.1371/journal.ppat.1007065. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29851986 Free PMC article.
Chagasic cardiomyopathy is caused by Trypanosoma cruzi infection. Poly(ADP-ribose) polymerase 1 (PARP1) is known for its function in nuclear DNA repair. ...
Chagasic cardiomyopathy is caused by Trypanosoma cruzi infection. Poly(ADP-ribose) polymerase 1 (PARP1) is known for its function in …
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.
Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Neelakantan H, et al. Biochem Pharmacol. 2018 Jan;147:141-152. doi: 10.1016/j.bcp.2017.11.007. Epub 2017 Nov 15. Biochem Pharmacol. 2018. PMID: 29155147 Free PMC article.
NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD(+) and S-(5'-adenosyl)-l-methionine (SAM), and suppressed lipogenesis in adipocytes. ...
NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD(+) and S-(5'-adenosyl)-l-methionine (SAM), and suppressed li …
Evolution on the Biophysical Fitness Landscape of an RNA Virus.
Rotem A, Serohijos AWR, Chang CB, Wolfe JT, Fischer AE, Mehoke TS, Zhang H, Tao Y, Lloyd Ung W, Choi JM, Rodrigues JV, Kolawole AO, Koehler SA, Wu S, Thielen PM, Cui N, Demirev PA, Giacobbi NS, Julian TR, Schwab K, Lin JS, Smith TJ, Pipas JM, Wobus CE, Feldman AB, Weitz DA, Shakhnovich EI. Rotem A, et al. Mol Biol Evol. 2018 Oct 1;35(10):2390-2400. doi: 10.1093/molbev/msy131. Mol Biol Evol. 2018. PMID: 29955873 Free PMC article.
Molecular switch-like regulation enables global subunit coordination in a viral ring ATPase.
Tafoya S, Liu S, Castillo JP, Atz R, Morais MC, Grimes S, Jardine PJ, Bustamante C. Tafoya S, et al. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7961-7966. doi: 10.1073/pnas.1802736115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012596 Free PMC article.
Our results reveal the molecular interactions necessary for the coordination of ADP-ATP exchange and ATP hydrolysis of the motor's biphasic mechanochemical cycle. We show that two distinct regulatory mechanisms determine this coordination. In the first mechanism, the DNA u …
Our results reveal the molecular interactions necessary for the coordination of ADP-ATP exchange and ATP hydrolysis of the motor's bi …
20 results