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8,707 results

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The following term was not found in PubMed: Doaly
Page 1
Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials.
Lotfy A, AboQuella NM, Wang H. Lotfy A, et al. Stem Cell Res Ther. 2023 Apr 7;14(1):66. doi: 10.1186/s13287-023-03287-7. Stem Cell Res Ther. 2023. PMID: 37024925 Free PMC article. Review.
MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number of clinical studies started to assess the therapeutic effect of MSC-Exos in different diseases. In this review, we summarized the ongoing and completed clinical studies using MSC …
MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number of clinical studies started to assess the therap …
Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation.
Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S. Willis GR, et al. Am J Respir Crit Care Med. 2018 Jan 1;197(1):104-116. doi: 10.1164/rccm.201705-0925OC. Am J Respir Crit Care Med. 2018. PMID: 28853608 Free PMC article.
We have reported that the therapeutic capacity of MSCs is comprised in their secretome, and demonstrated that the therapeutic vectors are exosomes produced by MSCs (MSC-exos). OBJECTIVES: To assess efficacy of MSC-exo treatment in a preclinical model of BPD and to i …
We have reported that the therapeutic capacity of MSCs is comprised in their secretome, and demonstrated that the therapeutic vectors are ex …
Mechanoregulation of MSC spheroid immunomodulation.
Thai VL, Mierswa S, Griffin KH, Boerckel JD, Leach JK. Thai VL, et al. APL Bioeng. 2024 Mar 1;8(1):016116. doi: 10.1063/5.0184431. eCollection 2024 Mar. APL Bioeng. 2024. PMID: 38435468 Free PMC article.
While mechanical stimulation of monodisperse cells can increase cytokine production, the influence of mechanical loading on MSC spheroids is unknown. Here, we evaluated the effect of controlled, uniaxial cyclic compression on the secretion of immunomodulatory cytokines by …
While mechanical stimulation of monodisperse cells can increase cytokine production, the influence of mechanical loading on MSC spher …
Comprehensive Comparison of Extracellular Vesicles Derived from Mesenchymal Stem Cells Cultured with Fetal Bovine Serum and Human Platelet Lysate.
Zhang Y, Song J, Wang B, Wen Y, Jiang W, Zhang YL, Li ZL, Yu H, Qin SF, Lv LL, Tang TT, Liu BC. Zhang Y, et al. ACS Nano. 2025 Apr 1;19(12):12366-12381. doi: 10.1021/acsnano.5c02532. Epub 2025 Mar 20. ACS Nano. 2025. PMID: 40110859
In this study, we comprehensively compared the characterization of EVs derived from MSCs cultured in the medium with FBS (F-EVs) and HPL (H-EVs). Our study showed that HPL promoted MSC-EV production without compromising EVs critical quality attributes. Multiomics se …
In this study, we comprehensively compared the characterization of EVs derived from MSCs cultured in the medium with FBS (F-EVs) and HPL ( …
Mesenchymal Stem Cell-Derived Exosomal microRNAs in Cardiac Regeneration.
Bhaskara M, Anjorin O, Wang M. Bhaskara M, et al. Cells. 2023 Dec 11;12(24):2815. doi: 10.3390/cells12242815. Cells. 2023. PMID: 38132135 Free PMC article. Review.
MSC-derived exosomes (MSC-Exos) replicate the beneficial effects of MSCs by regulating various cellular responses and signaling pathways implicated in cardiac regeneration and repair. miRNAs constitute an important fraction of exosome content and are key contributor …
MSC-derived exosomes (MSC-Exos) replicate the beneficial effects of MSCs by regulating various cellular responses and signalin …
Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes.
Schrodt MV, Behan-Bush RM, Liszewski JN, Humpal-Pash ME, Boland LK, Scroggins SM, Santillan DA, Ankrum JA. Schrodt MV, et al. Stem Cell Res Ther. 2023 Aug 17;14(1):206. doi: 10.1186/s13287-023-03443-z. Stem Cell Res Ther. 2023. PMID: 37592321 Free PMC article.
This begs the questions of how variations in MSC quality affect monocyte phenotype and if viable MSCs are even needed to elicit an immunosuppressive response. ...We cultured viable or heat-inactivated human umbilical cord MSCs with human peripheral blood mononuclear cells …
This begs the questions of how variations in MSC quality affect monocyte phenotype and if viable MSCs are even needed to elicit an im …
Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence.
Zheng H, Liang X, Han Q, Shao Z, Zhang Y, Shi L, Hong Y, Li W, Mai C, Mo Q, Fu Q, Ma X, Lin F, Li M, Hu B, Li X, Zhang Y. Zheng H, et al. J Nanobiotechnology. 2021 Oct 21;19(1):332. doi: 10.1186/s12951-021-01077-y. J Nanobiotechnology. 2021. PMID: 34674708 Free PMC article.
MicroRNA sequencing revealed a higher level of miR-183-5p in Hemin-MSC-EXO than in MSC-EXO. MiR-183-5p knockdown partially abrogated the protective effects of Hemin-MSC-EXO in attenuating mitochondrial fission and cellular senescence of cardiomyocytes induced …
MicroRNA sequencing revealed a higher level of miR-183-5p in Hemin-MSC-EXO than in MSC-EXO. MiR-183-5p knockdown partially abr …
Translating MSC Therapy in the Age of Obesity.
Boland L, Bitterlich LM, Hogan AE, Ankrum JA, English K. Boland L, et al. Front Immunol. 2022 Jul 4;13:943333. doi: 10.3389/fimmu.2022.943333. eCollection 2022. Front Immunol. 2022. PMID: 35860241 Free PMC article. Review.
Mesenchymal stromal cell (MSC) therapy has seen increased attention as a possible option to treat a number of inflammatory conditions including COVID-19 acute respiratory distress syndrome (ARDS). ...Our aim is to combine insights from basic research in MSC biology …
Mesenchymal stromal cell (MSC) therapy has seen increased attention as a possible option to treat a number of inflammatory conditions …
Effects of Physical, Chemical, and Biological Stimulus on h-MSC Expansion and Their Functional Characteristics.
Castilla-Casadiego DA, Reyes-Ramos AM, Domenech M, Almodovar J. Castilla-Casadiego DA, et al. Ann Biomed Eng. 2020 Feb;48(2):519-535. doi: 10.1007/s10439-019-02400-3. Epub 2019 Nov 8. Ann Biomed Eng. 2020. PMID: 31705365 Free PMC article. Review.
In this review, we describe the role of those stimuli on h-MSC manufacturing, and how these stimuli positively promote h-MSC properties, impacting the cell manufacturing field for cell-based therapies. In addition, we discuss other process consideratio …
In this review, we describe the role of those stimuli on h-MSC manufacturing, and how these stimuli positively promote h …
Mesenchymal Stromal Cell Exosomes in Cardiac Repair.
Joladarashi D, Kishore R. Joladarashi D, et al. Curr Cardiol Rep. 2022 Apr;24(4):405-417. doi: 10.1007/s11886-022-01660-1. Epub 2022 Jan 29. Curr Cardiol Rep. 2022. PMID: 35092595 Free PMC article. Review.
Substantial preclinical evidence indicates that MSC exosomes recapitulate MSC cellular function in cardiac regeneration and repair. Therefore, in this review, we briefly discuss the latest research progress of MSC exosomes in cardiac repair and regeneration. …
Substantial preclinical evidence indicates that MSC exosomes recapitulate MSC cellular function in cardiac regeneration and re …
8,707 results