Mechanisms underlying seizures and hypothermia during busulphan administration.
El-Serafi I, Berglund S, BenKessou F, Codita A, Saghafian M, Lindskog D, Dorst MC, Silberberg G, Abedi-Valugerdi M, Zheng W, He R, Renault M, Zhou W, Yu C, Vosough M, Oerther S, Zhao Y, Mattsson J, Hassan M.
El-Serafi I, et al.
Bone Marrow Transplant. 2025 Aug;60(8):1120-1128. doi: 10.1038/s41409-025-02608-z. Epub 2025 May 3.
Bone Marrow Transplant. 2025.
PMID: 40319193
Free PMC article.
Busulphan metabolites were detectable in plasma and urine up to 72-h after the last Bu-dose. Sulfolane levels were high and reached maximum concentration at the time-point reported for the convulsions' occurrence. ...
Busulphan metabolites were detectable in plasma and urine up to 72-h after the last Bu-dose. Sulfolane levels were high and reached m …