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16 results

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Page 1
The Na/K-ATPase Oxidant Amplification Loop Regulates Aging.
Sodhi K, Nichols A, Mallick A, Klug RL, Liu J, Wang X, Srikanthan K, Goguet-Rubio P, Nawab A, Pratt R, Lilly MN, Sanabria JR, Xie Z, Abraham NG, Shapiro JI. Sodhi K, et al. Sci Rep. 2018 Jun 26;8(1):9721. doi: 10.1038/s41598-018-26768-9. Sci Rep. 2018. Retraction in: Sci Rep. 2022 Jun 1;12(1):9124. doi: 10.1038/s41598-022-13456-y. PMID: 29946187 Free PMC article. Retracted.
As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 old mice were given a western diet to stimulate oxidant injury or pNaKtide to antagonize the NKAL. ...
As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First …
Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy.
Liu J, Tian J, Chaudhry M, Maxwell K, Yan Y, Wang X, Shah PT, Khawaja AA, Martin R, Robinette TJ, El-Hamdani A, Dodrill MW, Sodhi K, Drummond CA, Haller ST, Kennedy DJ, Abraham NG, Xie Z, Shapiro JI. Liu J, et al. Sci Rep. 2016 Oct 4;6:34592. doi: 10.1038/srep34592. Sci Rep. 2016. PMID: 27698370 Free PMC article.
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification …
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive …
Segmental Yttrium-90 Radioembolization with Day-of-Calibration Resin Microspheres: Durable Transarterial Ablation for Solitary Hepatocellular Carcinoma.
Talenfeld AD, Peng R, McKenney AS, Cobb B, Chughtai KA, Kierans AS, Guniganti P, Song C, Soliman MM, Pan S, Wu A, RoyChoudhury A, May BJ, Currie BM, Malhotra A, Browne WF, Charalel RA, Panarelli NC, Lee KS. Talenfeld AD, et al. Cardiovasc Intervent Radiol. 2025 Sep;48(9):1289-1298. doi: 10.1007/s00270-025-04130-7. Epub 2025 Aug 14. Cardiovasc Intervent Radiol. 2025. PMID: 40813475
Median tumor sphere concentration was 79 k [23-206 k] spheres/mL. Local modified REsponse Evaluation Criteria in Solid Tumors (mRECIST) response rates were 18 (90%) complete (16 durable), one partial response, and one stable disease. ...
Median tumor sphere concentration was 79 k [23-206 k] spheres/mL. Local modified REsponse Evaluation Criteria in Solid Tumors …
Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents.
Goud NS, Ghouse SM, Vishnu J, Komal D, Talla V, Alvala R, Pranay J, Kumar J, Qureshi IA, Alvala M. Goud NS, et al. Bioorg Chem. 2019 Aug;89:103016. doi: 10.1016/j.bioorg.2019.103016. Epub 2019 May 28. Bioorg Chem. 2019. PMID: 31185390
Binding affinity studies by fluorescence spectroscopy and Surface Plasmon Resonance (SPR) showed that 6g binds to Gal-1 with binding constant (K(a)) of 1.2 10(4) M(-1) and equilibrium constant K(D) value of 5.76 10(-4) M respectively....
Binding affinity studies by fluorescence spectroscopy and Surface Plasmon Resonance (SPR) showed that 6g binds to Gal-1 with binding constan …
pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet.
Sodhi K, Srikanthan K, Goguet-Rubio P, Nichols A, Mallick A, Nawab A, Martin R, Shah PT, Chaudhry M, Sigdel S, El-Hamdani M, Liu J, Xie Z, Abraham NG, Shapiro JI. Sodhi K, et al. Sci Rep. 2017 Mar 15;7(1):193. doi: 10.1038/s41598-017-00306-5. Sci Rep. 2017. Retraction in: Sci Rep. 2022 May 30;12(1):9006. doi: 10.1038/s41598-022-13458-w. PMID: 28298638 Free PMC article. Retracted.
On this background, we speculated that blockade of Na/K-ATPase-induced ROS amplification with a specific peptide, pNaKtide, might attenuate the development of steatohepatitis. ...Collectively, this study demonstrates that the Na/K-ATPase/ROS amplification loop contr …
On this background, we speculated that blockade of Na/K-ATPase-induced ROS amplification with a specific peptide, pNaKtide, might att …
Silicon fertilization counteracts salinity-induced damages associated with changes in physio-biochemical modulations in spinach.
Naz R, Zaman QU, Nazir S, Komal N, Chen Y, Ashraf K, Al-Huqail AA, Alfagham A, Siddiqui MH, Ali HM, Khan F, Sultan K, Khosa Q. Naz R, et al. PLoS One. 2022 Jun 9;17(6):e0267939. doi: 10.1371/journal.pone.0267939. eCollection 2022. PLoS One. 2022. Retraction in: PLoS One. 2022 Sep 14;17(9):e0274205. doi: 10.1371/journal.pone.0274205. PMID: 35679266 Free PMC article. Retracted.
Moreover, Si-induced mitigation of salt stress was due to the depreciation in Na+/K+ ratio, Na+ ion uptake at the surface of spinach roots, and translocation in plant tissues, thereby reducing the Na+ ion accumulation. ...
Moreover, Si-induced mitigation of salt stress was due to the depreciation in Na+/K+ ratio, Na+ ion uptake at the surface of spinach …
The Role of Vitamin C: From Prevention of Pneumonia to Treatment of Covid-19.
Komal, Kumar J, Sen A. Komal, et al. Mater Today Proc. 2022 Nov 18. doi: 10.1016/j.matpr.2022.11.213. Online ahead of print. Mater Today Proc. 2022. PMID: 36415746 Free PMC article.
In our nutrition 14 vitamins are present namely A, B1 (Thiamine), B6(Pyridoxine), B12(Cyanocobalamin), C, D, E, K, niacin, folacin, choline, pantothenic acid and biotin. The main role of it is in treating common diseases like cold. ...
In our nutrition 14 vitamins are present namely A, B1 (Thiamine), B6(Pyridoxine), B12(Cyanocobalamin), C, D, E, K, niacin, folacin, c …
First Report of Tobacco streak virus Infecting Pigeon Pea (Cajanus cajan) in India.
Vemana K, Goud TES, Reddy DL, Venkateswarlu NC, Naik KSS, Kumar DS, Padma Latha Y, Desai S. Vemana K, et al. Plant Dis. 2014 Feb;98(2):287. doi: 10.1094/PDIS-07-13-0731-PDN. Plant Dis. 2014. PMID: 30708760
Symptomatic leaves were sap-inoculated onto 10 seedlings of cowpea (cv. Pusa Komal) using 0.01 M phosphate buffer (pH 7.0). Localized necrotic lesions developed in all the inoculated plants after 2 days post inoculation. ...Sharman et al. Australian Plant Dis. 6:54, 2011. …
Symptomatic leaves were sap-inoculated onto 10 seedlings of cowpea (cv. Pusa Komal) using 0.01 M phosphate buffer (pH 7.0). Localized …
Nanoporous Carbon Materials as Solid Contacts for Microneedle Ion-Selective Sensors.
Chipangura Y, Komal M, Brandao VSM, Sedmak C, Choi JS, Swisher SL, Bühlmann P, Stein A. Chipangura Y, et al. ACS Appl Mater Interfaces. 2024 Aug 28;16(34):44428-44439. doi: 10.1021/acsami.4c07683. Epub 2024 Aug 15. ACS Appl Mater Interfaces. 2024. PMID: 39146498
We compare the effects of carbon architecture and composition on specific capacitance of the material, on the ability to incorporate ion-selective membrane components in the pores, and on sensor performance. Functioning K(+) and H(+) ion-selective electrodes and reference …
We compare the effects of carbon architecture and composition on specific capacitance of the material, on the ability to incorporate ion-sel …
Comparative efficacy and safety of ozanimod and ponesimod for relapsing multiple sclerosis: A matching-adjusted indirect comparison.
Swallow E, Pham T, Patterson-Lomba O, Yin L, Gomez-Lievano A, Liu J, Tencer T, Gupte-Singh K. Swallow E, et al. Mult Scler Relat Disord. 2023 Mar;71:104551. doi: 10.1016/j.msard.2023.104551. Epub 2023 Feb 6. Mult Scler Relat Disord. 2023. PMID: 36791623 Free article.
Additionally, ozanimod was associated with a significantly lower risk of TEAEs (risk difference: -11.9% [95% CI: -16.8%, -7.0%]), AEs leading to discontinuation (-6.1% [95% CI: -8.9%, -3.4%]), and lymphocyte count <0.2 K/muL (-2.3% [95% CI: -4.2%, -0.5%]). There were no …
Additionally, ozanimod was associated with a significantly lower risk of TEAEs (risk difference: -11.9% [95% CI: -16.8%, -7.0%]), AEs leadin …
16 results