Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro.
Bozym RA, Chimienti F, Giblin LJ, Gross GW, Korichneva I, Li Y, Libert S, Maret W, Parviz M, Frederickson CJ, Thompson RB.
Bozym RA, et al.
Exp Biol Med (Maywood). 2010 Jun;235(6):741-50. doi: 10.1258/ebm.2010.009258.
Exp Biol Med (Maywood). 2010.
PMID: 20511678
Free PMC article.
We found that for PC-12, HeLa and HT-29 cell lines as well as primary cultures of cardiac myocytes and neurons in vitro in differing media, approximately 5 nmol/L free zinc (pZn = 8.3, where pZn is defined as--log(10) [free Zn(2+)]) produced apparently healthy cells, but 2 …
We found that for PC-12, HeLa and HT-29 cell lines as well as primary cultures of cardiac myocytes and neurons in vitro in differing media, …